The Role of Selenium in Nutrition

The Role of Selenium in Nutrition

1st Edition - October 28, 1986

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  • Author: Gerald F. Jr. Combs
  • eBook ISBN: 9780323146531

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The Role of Selenium in Nutrition reviews the most pertinent scientific literature dealing with the basic aspects of the present understanding of the roles of selenium (Se) in nutrition and health. The book begins with a general discussion of Se, covering its various forms, chemistry and physical properties, and techniques for Se analysis. This is followed by separate chapters on the environmental aspects of Se, including its presence in mineral deposits, soils, water, air, and uptake by plants; Se contents of human foods and animal feedstuffs; biological utilization of dietary Se; and absorption, excretion, metabolism, and tissue concentrations of Se. Subsequent chapters deal with the biochemical functions of Se; Se-related diseases of animals and livestock; the role of Se in human health and in support of normal immune function and disease resistance; and the relationship of Se and cancer. The final chapter reviews the evidence concerning the toxicity of Se compounds and sets this in perspective with current knowledge of the roles of Se in nutrition and health, and of the normal exposures of animals and humans to Se compounds.

Table of Contents

  • Preface


    1. Chemical Aspects of Selenium

    I. Forms of Selenium

    II. Chemistry of Selenium

    III. Analysis of Selenium


    2. Selenium in the Environment

    I. Selenium in Mineral Deposits

    II. Selenium in Soils

    III. Selenium in Water and Air

    IV. Uptake of Selenium by Plants

    V. Geo-Botanical Mapping of Areas of Selenium Deficiency and Excess


    3. Selenium in Foods and Feeds

    I. Selenium in Foods

    II. Sources of Variation in the Selenium Contents of Foods and Feeds

    III. Selenium in Human Diets

    IV. Selenium in Feedstuffs for Animals


    4. The Biological Availability of Selenium in Foods and Feeds

    I. Defining Selenium Bioavailability

    II. Approaches to the Estimation of Selenium Bioavailability

    III. Selenium Bioavailability Estimated by the Disease Preventative Approach

    IV. Selenium Bioavailability Estimated by the Tissue Residue Level Approach

    V. Selenium Bioavailability Estimated by the Functional Assay Approach

    VI. Comparison of the Different Approaches to the Estimation of Selenium Bioavailability

    VII. Factors Affecting the Bioavailability of Dietary Selenium

    VIII. Summary of Factors Affecting the Bioavailability of Selenium


    5. Absorption, Excretion, and Metabolism of Selenium

    I. Absorption and Transfer

    II. Excretion of Selenium

    III. Metabolism of Selenium

    IV. Tissue Concentrations of Selenium


    6. Biochemical Functions of Selenium

    I. Physical Properties of Selenium-Dependent Glutathione Peroxidase

    II. Mechanism of Selenium-Dependent Glutathione Peroxidase

    III. Biological Function of Selenium-Dependent Glutathione Peroxidase

    IV. Effects of Drugs on Selenium-Dependent Glutathione Peroxidase

    V. Other Functions of Selenium

    VI. Interrelationships of Selenium and Other Nutrients

    VII. Interrelationships of Selenium and Other Elements


    7. Selenium Deficiency Diseases of Animals

    I. Selenium Deficiency Diseases of Laboratory and Domestic Animals

    II. Selenium Deficiency Diseases of Livestock

    III. Dietary Requirements of Selenium for Laboratory and Livestock Species


    8. Selenium in Human Nutrition and Health

    I. The Nutritional Selenium Status of Human Populations

    II. Selenium Status in Different Life Cycle Phases

    III. Diseases Associated with Nutritional Deficiencies of Selenium

    IV. Selenium Status of Patients with Other Nonmalignant Diseases

    V. Other Factors Affecting Selenium Status

    VI. Dietary Requirements for Selenium


    9. Selenium in Immunity and Infection

    I. Effects of Selenium on Β Cell-Dependent Immune Functions

    II. Effects of Selenium on Τ Cell-Mediated Immune Functions

    III. Effects of Selenium on the Functions of Phagocytic Cells

    IV. Effects of Selenium on Infection


    10. Selenium and Cancer

    I. Effects of Selenium on Carcinogenesis in Experimental Animal Models

    II. Selenium and Cancer in Humans


    11. Effects of Selenium Excesses

    I. Early Experiences with Selenium Toxicities

    II. Selenium Toxicity in Animals

    III. Selenium Toxicity in Humans

    IV. Treatment of Selenium Toxicity

    V. Metabolic Bases of Selenium Toxicity

    VI. Factors Affecting Selenium Toxicity

    VII. Safe Levels of Selenium



Product details

  • No. of pages: 544
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: October 28, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323146531

About the Author

Gerald F. Jr. Combs

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