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The Role of Selenium in Nutrition - 1st Edition - ISBN: 9780121834951, 9780323146531

The Role of Selenium in Nutrition

1st Edition

Author: Gerald F. Jr. Combs
eBook ISBN: 9780323146531
Imprint: Academic Press
Published Date: 28th October 1986
Page Count: 544
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The Role of Selenium in Nutrition reviews the most pertinent scientific literature dealing with the basic aspects of the present understanding of the roles of selenium (Se) in nutrition and health. The book begins with a general discussion of Se, covering its various forms, chemistry and physical properties, and techniques for Se analysis. This is followed by separate chapters on the environmental aspects of Se, including its presence in mineral deposits, soils, water, air, and uptake by plants; Se contents of human foods and animal feedstuffs; biological utilization of dietary Se; and absorption, excretion, metabolism, and tissue concentrations of Se. Subsequent chapters deal with the biochemical functions of Se; Se-related diseases of animals and livestock; the role of Se in human health and in support of normal immune function and disease resistance; and the relationship of Se and cancer. The final chapter reviews the evidence concerning the toxicity of Se compounds and sets this in perspective with current knowledge of the roles of Se in nutrition and health, and of the normal exposures of animals and humans to Se compounds.

Table of Contents



1. Chemical Aspects of Selenium

I. Forms of Selenium

II. Chemistry of Selenium

III. Analysis of Selenium


2. Selenium in the Environment

I. Selenium in Mineral Deposits

II. Selenium in Soils

III. Selenium in Water and Air

IV. Uptake of Selenium by Plants

V. Geo-Botanical Mapping of Areas of Selenium Deficiency and Excess


3. Selenium in Foods and Feeds

I. Selenium in Foods

II. Sources of Variation in the Selenium Contents of Foods and Feeds

III. Selenium in Human Diets

IV. Selenium in Feedstuffs for Animals


4. The Biological Availability of Selenium in Foods and Feeds

I. Defining Selenium Bioavailability

II. Approaches to the Estimation of Selenium Bioavailability

III. Selenium Bioavailability Estimated by the Disease Preventative Approach

IV. Selenium Bioavailability Estimated by the Tissue Residue Level Approach

V. Selenium Bioavailability Estimated by the Functional Assay Approach

VI. Comparison of the Different Approaches to the Estimation of Selenium Bioavailability

VII. Factors Affecting the Bioavailability of Dietary Selenium

VIII. Summary of Factors Affecting the Bioavailability of Selenium


5. Absorption, Excretion, and Metabolism of Selenium

I. Absorption and Transfer

II. Excretion of Selenium

III. Metabolism of Selenium

IV. Tissue Concentrations of Selenium


6. Biochemical Functions of Selenium

I. Physical Properties of Selenium-Dependent Glutathione Peroxidase

II. Mechanism of Selenium-Dependent Glutathione Peroxidase

III. Biological Function of Selenium-Dependent Glutathione Peroxidase

IV. Effects of Drugs on Selenium-Dependent Glutathione Peroxidase

V. Other Functions of Selenium

VI. Interrelationships of Selenium and Other Nutrients

VII. Interrelationships of Selenium and Other Elements


7. Selenium Deficiency Diseases of Animals

I. Selenium Deficiency Diseases of Laboratory and Domestic Animals

II. Selenium Deficiency Diseases of Livestock

III. Dietary Requirements of Selenium for Laboratory and Livestock Species


8. Selenium in Human Nutrition and Health

I. The Nutritional Selenium Status of Human Populations

II. Selenium Status in Different Life Cycle Phases

III. Diseases Associated with Nutritional Deficiencies of Selenium

IV. Selenium Status of Patients with Other Nonmalignant Diseases

V. Other Factors Affecting Selenium Status

VI. Dietary Requirements for Selenium


9. Selenium in Immunity and Infection

I. Effects of Selenium on Β Cell-Dependent Immune Functions

II. Effects of Selenium on Τ Cell-Mediated Immune Functions

III. Effects of Selenium on the Functions of Phagocytic Cells

IV. Effects of Selenium on Infection


10. Selenium and Cancer

I. Effects of Selenium on Carcinogenesis in Experimental Animal Models

II. Selenium and Cancer in Humans


11. Effects of Selenium Excesses

I. Early Experiences with Selenium Toxicities

II. Selenium Toxicity in Animals

III. Selenium Toxicity in Humans

IV. Treatment of Selenium Toxicity

V. Metabolic Bases of Selenium Toxicity

VI. Factors Affecting Selenium Toxicity

VII. Safe Levels of Selenium




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© Academic Press 1986
28th October 1986
Academic Press
eBook ISBN:

About the Author

Gerald F. Jr. Combs

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