The Role of Products of the Histocompatibility Gene Complex in Immune Responses - 1st Edition - ISBN: 9780124016606, 9781483273440

The Role of Products of the Histocompatibility Gene Complex in Immune Responses

1st Edition

Editors: David H. Katz Baruj Benacerraf
eBook ISBN: 9781483273440
Imprint: Academic Press
Published Date: 1st January 1976
Page Count: 802
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The Role of Products of the Histocompatibility Gene Complex in Immune Responses documents the proceedings of a conference held on 3-7 November 1975, which brought together an international group of scientists spanning three independent disciplines—genetics and immunogenetics, molecular biochemistry, and immunobiology—with clinical medicine overlapping these disciplines. This volume contains 42 papers organized according to the eight sessions held at the conference. The papers in Session I examined the genetics of the major histocompatibility complex. Session II presented studies on the biology of mixed lymphocyte interactions and cell-mediated cytotoxicity reactions. Session III discussed immune response gene systems while Session IV dealt with the genetic control of cell interactions. The papers in Session V covered idiotypic determinants on T cell receptors. Session VI investigated the properties of histocompatibility gene products involved in regulation of immune responses. Session VII focused on the biochemistry and immunocytology of cell surface products of the major histocompatibility complex. Finally, Session VIII discussed interrelationships between products of the major histocompatibility complex and their relevance to disease.

Table of Contents



Photographs of Participants

Session 1: Genetics of the Major Histocompatibility Complex

Genetic Resolution of the Products and Functions of I and S Region Genes of the Mouse H-2 Complex

Discussion following Donald Shreffler

The Genetics of the Major Histocompatibility Complex in Man, HLA

Discussion following Jon van Rood

Molecular Relationships of Ia Antigens Controlled by the Same and by Different Subregions of the I Region

Br and Wh, B Cell Antigens in Gluten Sensitive Enteropathy and Dermatitis Herpetiformis

Recent Studies of Ia like Antigens and Complement Components Relating to the Human Histocompatibility System

Natural Killer Cells in the Mouse

Evidence for the Association of Specificity Ia. 3 with an I-A Region Molecule

General Discussion — Session

Session II: The Biology of Mixed Lymphocyte Interactions and Cell-Mediated Cytotoxicity Reactions

Genetic and Cellular Aspects of Mixed Leukocyte Culture and Cell Mediated Lympholysis Reactions

Discussion following Fritz Bach

Bifunctional Histocompatibility-Linked Regulation of Cell Mediated Lympholysis to Modified Autologous Cell Surface Components

Discussion following Gene Shearer

The Role of Ia Antigens in MLC Stimulation

H-2 Associated MLR Determinants: Immunogenetics of the Loci and Their Products

Responses of Alloantigen Reactive Lymphocytes to Conventional Antigens

Evidence for Several Closely Linked Genes Involved in Generation of Proliferation in MLC

Suppressive Interactions between Different MLR Loci

Does the Apparent H-2 Compatibility Requirement for Virus-Specific T Cell-Mediated Cytolysis Reflect T Cell Specificity for "Altered Self" or Physiological Interaction Mechanisms?

General Discussion — Session

Session III: Immune Response (Ir) Gene Systems

The Nature and Function of Specific H-Linked Immune Response Genes and Immune Suppression Genes

Discussion following Baruj Benacerraf

Functional Analysis of Ia Antigens in Relation to Genetic Control of the Immune Response

Discussion following Hugh McDevitt

H-2 Linked Immune Response Genes: Multiplicity and Functional Complementation

H-3-Linked Unresponsiveness to EA-1 and H-13 Antigens

Immune Responses of Mice against Modified Random Polymers of Amino Acids, and Implications in Gene Control

A Possible Function for Products of the Major Histocompatibility Complex in Humoral Immunity

General Discussion — Session

Session IV: Genetic Control of Cell Interactions

Macrophage-T Lymphocyte Interaction: The Cellular Basis for Genetic Control of Antigen Recognition

Discussion following Alan Rosenthal

Genetic Control of Lymphocyte Interactions and Differentiation

Discussion following David Katz

Stimulation of Antibody Responses In Vitro by Antigen-Bearing Syngeneic and Allogeneic Macrophages

H-2 Linked Ir Gene Regulation of Delayed-Type Hypersensitivity in Mice

Differential Expression of Ia Antigens on Suppressor T Cells, Helper T Cells, and B Precursor Cells

Effective Allogeneic T Cell-B Cell Interaction in Chimeric Mice

General Discussion — Session

Session V: Idiotypic Determinants on T Cell Receptors

T Lymphocyte Receptor Analysis by Anti-Idiotypic Stimulation

Discussion following Klaus Rajewsky

Idiotypic Receptors for Antigen on T Lymphocytes

Discussion following Hans Wigzell

Session VI: Properties of Histocompatibility Gene Products Involved in Regulation of Immune Responses

The Nature of Antigen Specific T Cell Factors Involved in the Genetic Regulation of Immune Responses

Discussion following Edna Mozes

Characterization of the Antigen-Specific Suppressive T Cell Factor with Special Reference to the Expression of I Region Genes

Discussion following Tomio Tada

Histocompatibility Gene Products as Mediators of Lymphocyte Interactions

I-Region Gene Products in Cell Cooperation

Suppressive Activity of Lymphoid Cell Extracts from Non-Responder Mice Injected with the Terpolymer L-Glutamic Acid60-L-Alanine30-L-Tyrosine10 (GAT)

Anti-ß2 Microglobulin — a Selective PBA for Human and Mouse B Lymphocytes

General Discussion — Session

Session VII: Biochemistry and Immunocytology of Cell Surface Products of the Major Histocompatibility Complex

Cytological Analysis of Histocompatibility Molecules

Discussion following Emil Unanue

Isolation and Structure of Products of the Human Histocompatibility Gene Complex

Discussion following Jack Strominger

Studies on the Chemical Basis of Variability and the Complex Cellular Expression of the H-2K and H-2D Products

Discussion following Stanley Nathenson

Structure and Biological Activity of H-2 Antigens

Genetic and Evolutionary Implications of the Partial Amino Acid Sequences of H-2K and H-2D Alloantigens

The Chemistry of Mouse and Guinea Pig Ia Antigens

General Discussion — Session

Session VIII: Interrelationships between Products of the Major Histocompatibility Complex and Their Relevance to Disease

General Discussion

1a) Specificity of H-Linked Ir Gene Function

1b) Microheterogeneity of Ia Molecules

2) Evidence for Existence of a Distinct 1-B Sub-Region

3a, b, c) Nature of the Antigen Receptor on T Cell Factors and Relationship to vH Regions and Ig Idiotypes; Their Specificity Range as Compared to Immunoglobulins; and Possible Existence of Dual Recognition Systems at the T Cell Level and at Other Levels

4) Similarities and Differences between Helper and Suppressor Factors

5) Basis for the Large Numbers of Allospecific T Cells Recognizing MHC Antigens

6) The Phenomenon of Cis-Trans Preference in Complementation of Ir Genes and Its Relevance to Linkage Disequilibrium in MHC

7) The Basis for Presence or Absence of Genetic Restrictions in T-B Cell Cooperation — Adaptation or Selection?

Relationship of the MHC to Disease


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© Academic Press 1976
Academic Press
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About the Editor

David H. Katz

Baruj Benacerraf

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