The Role of Chromosomes in Development

The Role of Chromosomes in Development

1st Edition - January 1, 1964

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  • Editor: Michael Locke
  • eBook ISBN: 9780323156851

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The Role of Chromosomes in Development is a collection of papers presented at the 23rd Symposium of the Society for the Study of Development and Growth, held at Amherst, Massachusetts in June 1964. Contributors explore the role of chromosomes in development, highlighting important processes such as the diversification and specialization of cells; the regulation of gene function by the physical state of the chromosome; the functional organization of chromosomes; DNA replication and synthesis; and macronuclear differentiation and subnuclear assortment. This volume is organized into 11 chapters and begins with an overview of chromosome structure and function and the mechanisms underlying the role of the chromosome in embryonic development. This book then discusses the chromosomal DNA replication, the mechanisms of gene modulation, the binding of actinomycin to DNA, and the cytological aspects of DNA replication in higher animals. The next chapters explain localized DNA synthesis in polytene chromosomes; chromosomal RNA and other nuclear RNA fractions; and experimental work probing both genetic and functional mosaicism in the mouse, as well as genetic repression of the R locus in maize. The book also considers how developmental pathways are controlled by genetic mechanisms, and then concludes with a chapter on nuclear differentiation in ciliates and on the phenomenon of subnuclear assortment. This book will be of interest to developmental biologists and embryologists.

Table of Contents

  • Contributors and Presiding Chairmen


    The Role of Chromosomes in Development



    Structural Patterns and the Functional Organization of Chromosomes


    Repository Function


    Discussion and Summary


    Chromosomal Proteins

    Proteins and Chromosome Structure

    The Acidic Nuclear Proteins

    The Acidic Proteins and Gene Modulation

    The Histones and Gene Modulation

    Structure of the N-Proline Histone

    Mechanisms of Gene Modulation

    Functional State of the Genome



    Binding of Actinomycin as a Model for the Complex-Forming Capacity of DNA



    DNA Replication Sequences in Higher Animals


    Materials and Methods

    The Relationship between Heteropyknosis, Gene Inactivation, and DNA Replication

    The Terminal Stages of DNA Replication

    Late Replication and Metaphase Chromosome Morphology

    The Commencement of DNA Replication

    Quantitative Autoradiography of Chromosomes



    Localized DNA Synthesis in Polytene Chromosomes and Its Implications



    Chromosomal RNA and Other Nuclear RNA Fractions

    Chromosomal RNA

    Nucleolar RNA

    Nuclear Sap RNA



    Genetic and Functional Mosaicism in the Mouse

    Genetic Mosaicism

    Functional Mosaicism



    Genetic Repression of R Action in Maize

    Experimental Materials and Methods

    Paramutation of Rr in RrRst and Rrrr Heterozygotes

    Partial Reversion of Paramutant R

    Changes in Action of Rr and R9 Alleles from Stock Cultures in Heterozygotes with Each Other

    Acquisition of Paramutagenicity by Rr in Stippled Hétérozygotes

    Association of the R Locus with Paramutation

    Continuous Variation in Paramutation

    Compound Nature of the Stippled Allele

    Progressive Paramutation in Successive Generations

    Occurrence of Paramutation in Somatic Cells

    Manifestation of Paramutation in Sporophytic Tissues

    The Origin and Geographic Distribution of Paramutable and Nonparamutable R Alleles

    R Action in Structurally Altered Chromosome 10

    Paramutability of Rr When Carried by Chromosome K10

    Level of R Action in Relation to Mode of Sexual Transmission

    Effects on Rr and Rst of High Energy Irradiation

    Is a Gene-Dependent Cytoplasmic Particle Associated with R Paramutation?

    Paramutation in Other Organisms

    Summary and Discussion


    Genetic Control and Regulation of Developmental Pathways


    Genetic Methods for the Analysis of Development

    The Bithorax Pseudoallelic Series

    Developmental Effects of the Bithorax Mutants

    Gene Dosage Studies

    Somatic Mosaics

    Cis-Trans Effects

    The Trans-Vection Effect




    Macronuclear Differentiation and Subnuclear Assortment in Ciliates

    Morphological Nuclear Differentiation

    Caryonidal Distribution: Mating Type Differentiation in Syngen 1, Paramecium aurelia

    Subnuclear Assortment: Mating Type Differentiation in Syngen 1, Tetrahymena pyriformis

    Subnuclear Assortment: Allelic Repression or Hétérozygote Resolution?



    Author Index

    Subject Index

Product details

  • No. of pages: 302
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9780323156851

About the Editor

Michael Locke

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