The Rhesus Monkey

The Rhesus Monkey discusses the use of the rhesus monkey as a test subject in biomedical research. This text provides information that is essential for research that involves the rhesus monkey, from conditioning a wild rhesus monkey to restoring it to its natural state after the tests that it is subjected to. This book covers the phases a rhesus monkey specimen will go through in an experiment. Each chapter covers different facets of using a rhesus monkey as a test subject, including selecting a suitable specimen, conditioning, medication, nourishment, breeding, and pathological threats. Researchers in all fields will find this book an invaluable source of information regarding the best use of rhesus monkeys as research subjects.

List of Contributors

Preface

Contents of Volume I

1 Conditioning Wild Rhesus for Biomedical Research

I Stabilization

II Therapeutic Procedures

III Suitable Animal Models

References

2 Medical Management of the Rhesus Monkey

I Introduction

II Preventive Medicine

III Basics of Medical Management

IV Differential Diagnosis

V General Discussion—Diseases and Therapy

VI Respiratory Diseases

VII Generalized Diseases

VIII General Discussion

IX Conclusions

References

3 Nutrition of the Rhesus Monkey

I Energy

II Protein

III Fat

IV Vitamin A

V Vitamin D

VI Vitamin Κ

VII Vitamin Ε

VIII Thiamine

IX Riboflavin

X Niacin

XI Pyridoxine

XII Pantothenic Acid

XIII Biotin

XIV Folic Acid

XV Vitamin B12

XVI Choline

XVII Vitamin C

XVIII Minerals

XIX Water

XX Bulk

XXI Milk of Rhesus Monkeys

References

4 Reproduction in the Rhesus Monkey, Macaca mulatta

I Reproduction in the Female: The Reproductive Cycle

II Reproduction in the Male

References

5 Embryology of the Rhesus Monkey

I Fertilization

II Cleavage

III Implantation

IV Bilaminar Disc

V Trilaminar Disc

VI Organogenesis

VII Comparison to the Human Embryo

VIII Extraembryonic Membranes

IX Placentation

X Fetal Period

References

6 Pregnancy in the Rhesus Monkey

I General Aspects

II Metabolic Changes

III Circulation, Placenta, and Placental Circulation

IV Fetus

V Parturition

References

7 Behavior of the Female Rhesus Monkey during Birth

I Introduction

II Field Studies of Birth

III Mechanisms of Parturition

IV Original Studies

V Methodology at Davis

VI Signs of Labor

VII The Delivery

VIII Presentation Complications

IX Behavior by the Mother following Delivery

X Reactions of Other Animals

XI Summary

References

8 The Assessment of Skeletal Development in the Rhesus Monkey (Macaca mulatta) and Its Relationship to Growth and Sexual Maturity

I Introduction

II Material and Method

III Results

IV Conclusions

References

9 Breeding Monkeys for Biomedical Research

I Introduction

II Types of Breeding Procedures

III Breeding Program at the Yerkes Primate Research Center

IV Number of Animals Used in Breeding Group

V Nutrition

VI Birth Data

References

10 Circadian Rhythms of the Rhesus Monkey

I Introduction

II Circadian Synchrony

III Experimental Requirements

IV Zeitgebers

V Other Factors that Affect Circadian Synchrony

VI Concluding Remarks

References

11 Immunogenetic Studies of Rhesus

I Introduction

II Antigens of Erythrocytes

III Antigens of Leukocytes and Histocompatibility

IV Antigens of Serum

V Biochemical Polymorphisms

VI Maternal-Fetal Incompatibility and Hemolytic Disease of the Newborn

VII Comments and Conclusions

References

12 Pathology of the Rhesus Monkey

I Introduction

II Literature Review

III Observations in the Yerkes Colony

IV Summary

References

13 Neoplasia in Rhesus Monkeys

I Introduction

II Tumors of the Skin and Subcutaneous Tissues

III Tumors of the Musculoskeletal System

IV Tumors of the Gastrointestinal Tract

V Tumors of the Liver and Biliary Tract

VI Tumors of the Cardiovascular System

VII Tumors of the Respiratory System

VIII Tumors of the Pancreas and Endocrine System

IX Tumors of the Urinary System

X Tumors of the Genital Organs and Mammary Gland

XI Tumors of the Central Nervous System

XII Leukemia and Lymphomas

XIII Proliferative Lesions Other than Neoplasms

XIV Tumors Observed in Rhesus Monkeys of the Yerkes Colony

XV Summary

References

14 Cytogenetics of the Rhesus

I Introduction

II Culture Techniques

III The Normal Chromosome Complement

IV Abnormal Chromosome Complements

V Experimental Studies

VI Summary

References

15 Hematologic, Blood Chemistry, and Cerebrospinal Fluid Data for the Rhesus Monkey

I Introduction

II Literature Review

III Hematologic and Blood Chemistry Values of Rhesus Monkeys of the Yerkes Colony

IV Results

V Discussion

VI Summary

References

Subject Index