The Retina A Model for Cell Biology Studies Part_2 - 1st Edition - ISBN: 9780120442768, 9780323154192

The Retina A Model for Cell Biology Studies Part_2

1st Edition

Editors: Ruben Adler
eBook ISBN: 9780323154192
Imprint: Academic Press
Published Date: 12th May 1986
Page Count: 362
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The Retina: A Model for Cell Biology Studies, Part II, is the second of a two-part series that details developments in the study of retinal cell biology.
The book begins with a review of the current evidence for the role of putative neurotransmitters at particular synapses in the retina. It then discusses pre- and postsynaptic regulatory mechanisms; the interactions of neurotransmitter-neuromodulatory systems; and cellular effects of putative neurotransmitters and neuromodulators. This is followed by an introduction to vision psychophysics, showing its application in studying the functioning of cells in the retina. The remaining chapters discuss how the retinal pigment epithelium cell might be used as a model for studying biological problems of current interest; extracellular matrix molecules; concepts and controversies regarding the biology of endothelial cells, the key elements in the phenomenon of intraocular neovascularization; the use of genetic mutations and genetic mosaics for the study of the retina; and the retina as a regenerating organ.

Table of Contents



Neurotransmitters and Neuromodulators in the Retina: Regulation, Interactions, and Cellular Effects

I. Introduction

II. Putative Neurotransmitters and Neuromodulators of Retinal Neurons

III. Pre- and Postsynaptic Regulatory Mechanisms

IV. Interactions of Neurotransmitters and Neuromodulators

V. Cellular and Morphological Effects of Neurotransmitters and Neuromodulators

VI. Concluding Remarks


Vision Psychophysics and Retinal Cell Biology

I. Introduction

II. The Systems Approach of Psychophysics

III. Psychophysical Studies of Photoreceptor Physiology

IV. Psychophysical Studies of Abnormal Retinal Physiology in Retinitis Pigmentosa

V. Retinal Cell Biology from a Psychophysicist's Perspective


The Cell Biology of the Retinal Pigment Epithelium

I. Summary of RPE Cell Structure and Functions

II. Cellular Processes That Have Been Studied in the RPE

III. Use of Cultured RPE Cells to Study Cellular Processes

IV. Summary and Future Research


Extracellular Matrix Molecules: Their Importance in the Structure and Function of the Retina

I. Introduction

II. Extracellular Matrices

III. Retinal Extracellular Matrices

IV. Effects of Extracellular Matrix Molecules on Retinal Neurons

V. Concluding Comments


Cell Biology and Biochemistry of Endothelial Cells and the Phenomenon of Intraocular Neovascularization

I. Introduction

II. New Vessels from Preexisting Vessels

III. Steps in Capillary Formation

IV. Maturation of the Vascular Bed

V. Factors Influencing Capillary Sprout Formation

VI. Conclusion


Genetic Mosaics as Tolls for the Study of the Retina

I. A Modest Catalog of Known Mutations Affecting the Eye

II. Genetic Mosaics: A Primer

III. The Study of the Site of Gene Action

IV. The Study of Cell Lineage

V. The Study of Embryonic Retinal Development

VI. General Conclusions


The Retina as a Regenerating Organ

I. Introduction

II. Characteristics of Regenerating Goldfish Retinal Ganglion Cells

III. Conditions That Modify Axonal Outgrowth

IV. Regulation of the Cell Body Reaction

V. General Conclusions




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© Academic Press 1986
Academic Press
eBook ISBN:

About the Editor

Ruben Adler

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