The Retina A Model for Cell Biology Studies Part_2

The Retina A Model for Cell Biology Studies Part_2

1st Edition - January 1, 1986

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  • Editor: Ruben Adler
  • eBook ISBN: 9780323154192

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The Retina: A Model for Cell Biology Studies, Part II, is the second of a two-part series that details developments in the study of retinal cell biology. The book begins with a review of the current evidence for the role of putative neurotransmitters at particular synapses in the retina. It then discusses pre- and postsynaptic regulatory mechanisms; the interactions of neurotransmitter-neuromodulatory systems; and cellular effects of putative neurotransmitters and neuromodulators. This is followed by an introduction to vision psychophysics, showing its application in studying the functioning of cells in the retina. The remaining chapters discuss how the retinal pigment epithelium cell might be used as a model for studying biological problems of current interest; extracellular matrix molecules; concepts and controversies regarding the biology of endothelial cells, the key elements in the phenomenon of intraocular neovascularization; the use of genetic mutations and genetic mosaics for the study of the retina; and the retina as a regenerating organ.

Table of Contents

  • Contributors


    Neurotransmitters and Neuromodulators in the Retina: Regulation, Interactions, and Cellular Effects

    I. Introduction

    II. Putative Neurotransmitters and Neuromodulators of Retinal Neurons

    III. Pre- and Postsynaptic Regulatory Mechanisms

    IV. Interactions of Neurotransmitters and Neuromodulators

    V. Cellular and Morphological Effects of Neurotransmitters and Neuromodulators

    VI. Concluding Remarks


    Vision Psychophysics and Retinal Cell Biology

    I. Introduction

    II. The Systems Approach of Psychophysics

    III. Psychophysical Studies of Photoreceptor Physiology

    IV. Psychophysical Studies of Abnormal Retinal Physiology in Retinitis Pigmentosa

    V. Retinal Cell Biology from a Psychophysicist's Perspective


    The Cell Biology of the Retinal Pigment Epithelium

    I. Summary of RPE Cell Structure and Functions

    II. Cellular Processes That Have Been Studied in the RPE

    III. Use of Cultured RPE Cells to Study Cellular Processes

    IV. Summary and Future Research


    Extracellular Matrix Molecules: Their Importance in the Structure and Function of the Retina

    I. Introduction

    II. Extracellular Matrices

    III. Retinal Extracellular Matrices

    IV. Effects of Extracellular Matrix Molecules on Retinal Neurons

    V. Concluding Comments


    Cell Biology and Biochemistry of Endothelial Cells and the Phenomenon of Intraocular Neovascularization

    I. Introduction

    II. New Vessels from Preexisting Vessels

    III. Steps in Capillary Formation

    IV. Maturation of the Vascular Bed

    V. Factors Influencing Capillary Sprout Formation

    VI. Conclusion


    Genetic Mosaics as Tolls for the Study of the Retina

    I. A Modest Catalog of Known Mutations Affecting the Eye

    II. Genetic Mosaics: A Primer

    III. The Study of the Site of Gene Action

    IV. The Study of Cell Lineage

    V. The Study of Embryonic Retinal Development

    VI. General Conclusions


    The Retina as a Regenerating Organ

    I. Introduction

    II. Characteristics of Regenerating Goldfish Retinal Ganglion Cells

    III. Conditions That Modify Axonal Outgrowth

    IV. Regulation of the Cell Body Reaction

    V. General Conclusions



Product details

  • No. of pages: 362
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: January 1, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323154192

About the Editor

Ruben Adler

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