The Retina A Model for Cell Biology Studies Part_1

1st Edition - April 28, 1986
Editor: Ruben Adler
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 0 7 2 - 0

The Retina: A Model for Cell Biology Studies, Part I, is the first of a two-part series that details developments in the study of retinal cell biology. The book begins with some… Read more

The Retina A Model for Cell Biology Studies Part_1

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The Retina: A Model for Cell Biology Studies, Part I, is the first of a two-part series that details developments in the study of retinal cell biology. The book begins with some basic information about retinal structure and development followed by a discussion of the advantages of the retina as a model system for cell biology studies. It reviews some of the major events in the maturation of the retina pertinent to the assembly of neuronal circuits. The book describes studies of neuronal assembly in order to demonstrate that adhesion-based neuronal assembly may be the most elaborated example of a wider class of morphogenetic phenomena categorized as ""adhesion-guided multicellular assembly"" systems. The remaining chapters discuss in vivo and in vitro studies on trophic interactions in retinal development and in retinal degenerations; cell motility in the retina; molecular properties of vertebrate rod cells; the role of cyclic nucleotides in the metabolism and function of the retina; and the cellular and molecular aspects of photosensitive membrane turnover.

Contributors

Preface

Issues and Questions in Cell Biology of the Retina

I. Introduction

II. The Adult Retina

III. The Developing Retina

IV. The Pathological Retina

V. Concluding Remark

References

The Development of Retinal Networks

I. Introduction

II. The Development of Retinal Layers

III. Neurochemical Differentiation in the Retina

IV. Maturation of Retinal Networks

V. Summary

References

Differential Adhesion in Neuronal Development

I. Introduction

II. Neuronal Guidance Systems: Biological Studies

III. Molecular Mechanisms of Adhesion

IV. Neuronal Recognition and Differential Adhesion

References

Trophic Interactions in Retinal Development and In Retinal Degenerations. In Vivo and In Vitro Studies

I. Introduction

II. The Regulation of Neuronal Survival

III. The Search for "Trophic" and Other Regulatory Factors

IV. The Search for Molecules Controlling Survival and Differentiation of Retinal Neurons: In Vitro Studies

V. Concluding Remarks

References

Cell Motility in the Retina

I. Introduction

II. The Structural Machinery: The Cytoskeleton

III. Force-Producing Mechanisms

IV. Vertebrate Retinomotor Movements

V. Invertebrate Retinomotor Movements

VI. Cytoskeleton and Motility in RPE Cells

VII. Morphological Aspects of Retinal Synaptic Modulation

VIII. Alignment of Photoreceptors

IX. Concluding Remarks

References

Molecular Dynamics of the Rod Cell

I. Structure of the Rod Cell

II. Disk Membrane of the Rod Cell Outer Segment

III. Rhodopsin: The Photoreceptor Protein

IV. Light-Dependent Biochemistry of the Rod Cell

References

Cyclic Nucleotides in Retinal Function and Degeneration

I. Introduction

II. Cyclic Nucleotide Metabolism in Rod-Dominant Retinas

III. Cyclic Nucleotides in Cone-Dominant Retinas

IV. Abnormalities in Cyclic Nucleotide Metabolism in Retinal Degenerations

V. Future Prospects

References

Photosensitive Membrane Turnover: Differentiated Membrane Domains and Cell-Cell Interaction

I. Introduction

II. Synthesis and Assembly of Photosensitive Membrane

III. Disk Shedding and Phagocytosis

IV. Regulation of Membrane Turnover

V. Summary

References

Index