The Retina A Model for Cell Biology Studies Part_1

The Retina A Model for Cell Biology Studies Part_1

1st Edition - April 28, 1986

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  • Editor: Ruben Adler
  • eBook ISBN: 9780323140720

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The Retina: A Model for Cell Biology Studies, Part I, is the first of a two-part series that details developments in the study of retinal cell biology. The book begins with some basic information about retinal structure and development followed by a discussion of the advantages of the retina as a model system for cell biology studies. It reviews some of the major events in the maturation of the retina pertinent to the assembly of neuronal circuits. The book describes studies of neuronal assembly in order to demonstrate that adhesion-based neuronal assembly may be the most elaborated example of a wider class of morphogenetic phenomena categorized as ""adhesion-guided multicellular assembly"" systems. The remaining chapters discuss in vivo and in vitro studies on trophic interactions in retinal development and in retinal degenerations; cell motility in the retina; molecular properties of vertebrate rod cells; the role of cyclic nucleotides in the metabolism and function of the retina; and the cellular and molecular aspects of photosensitive membrane turnover.

Table of Contents

  • Contributors


    Issues and Questions in Cell Biology of the Retina

    I. Introduction

    II. The Adult Retina

    III. The Developing Retina

    IV. The Pathological Retina

    V. Concluding Remark


    The Development of Retinal Networks

    I. Introduction

    II. The Development of Retinal Layers

    III. Neurochemical Differentiation in the Retina

    IV. Maturation of Retinal Networks

    V. Summary


    Differential Adhesion in Neuronal Development

    I. Introduction

    II. Neuronal Guidance Systems: Biological Studies

    III. Molecular Mechanisms of Adhesion

    IV. Neuronal Recognition and Differential Adhesion


    Trophic Interactions in Retinal Development and In Retinal Degenerations. In Vivo and In Vitro Studies

    I. Introduction

    II. The Regulation of Neuronal Survival

    III. The Search for "Trophic" and Other Regulatory Factors

    IV. The Search for Molecules Controlling Survival and Differentiation of Retinal Neurons: In Vitro Studies

    V. Concluding Remarks


    Cell Motility in the Retina

    I. Introduction

    II. The Structural Machinery: The Cytoskeleton

    III. Force-Producing Mechanisms

    IV. Vertebrate Retinomotor Movements

    V. Invertebrate Retinomotor Movements

    VI. Cytoskeleton and Motility in RPE Cells

    VII. Morphological Aspects of Retinal Synaptic Modulation

    VIII. Alignment of Photoreceptors

    IX. Concluding Remarks


    Molecular Dynamics of the Rod Cell

    I. Structure of the Rod Cell

    II. Disk Membrane of the Rod Cell Outer Segment

    III. Rhodopsin: The Photoreceptor Protein

    IV. Light-Dependent Biochemistry of the Rod Cell


    Cyclic Nucleotides in Retinal Function and Degeneration

    I. Introduction

    II. Cyclic Nucleotide Metabolism in Rod-Dominant Retinas

    III. Cyclic Nucleotides in Cone-Dominant Retinas

    IV. Abnormalities in Cyclic Nucleotide Metabolism in Retinal Degenerations

    V. Future Prospects


    Photosensitive Membrane Turnover: Differentiated Membrane Domains and Cell-Cell Interaction

    I. Introduction

    II. Synthesis and Assembly of Photosensitive Membrane

    III. Disk Shedding and Phagocytosis

    IV. Regulation of Membrane Turnover

    V. Summary



Product details

  • No. of pages: 380
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: April 28, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323140720

About the Editor

Ruben Adler

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