The Red Blood Cell

The Red Blood Cell

Volume II

2nd Edition - January 28, 1975

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  • Editor: Douglas MacN. Surgenor
  • eBook ISBN: 9781483257501

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The Red Blood Cell, Second Edition, Volume II provides a comprehensive treatment and review of basic biomedical knowledge about the circulating, adult red blood cell. This book discusses the transport through red cell membranes; carrier-mediated glucose transport across human red cell membranes; and metabolism of methemoglobin in human erythrocytes. The interaction of oxygen and carbon dioxide with hemoglobin at the molecular level; physiological role of the oxyhemoglobin dissociation curve; hemoglobinopathies; and thalassemia syndromes are also deliberated. This publication likewise covers the red cell genetic polymorphisms; biological life of the red cell; clinical indications for red cells and blood; and biophysical behavior of red cells in suspensions. Other topics include the electrokinetic behavior of red cells; erythrocyte as a biopsy tissue in the evaluation of nutritional status; and knowledge of red cell purine and pyrimidine metabolism coming from the study of human disease. This volume is recommended for students, researchers, teachers, and physicians aiming to acquire knowledge of the red blood cell.

Table of Contents

  • List of Contributors


    Contents of Volume I

    Chapter 15. Transport through Red Cell Membranes

    I. Introduction

    II. Equilibrium Conditions

    III. Permeability to Water and Nonelectrolytes

    IV. Permeability to Charged Solutes


    Chapter 16. Carrier-Mediated Glucose Transport Across Human Red Cell Membranes

    I. Introduction

    II. Description of Carrier Mediation

    III. Kinetic Mechanisms of Carrier Mediation

    IV. Molecular Mechanisms of Carrier Mediation

    V. Identification and Isolation of the Carrier

    VI. Concluding Remarks


    Chapter 17. Hemoglobin and Methemoglobin

    I. Introduction

    II. Structure of Hemoglobin

    III. Derivatives of Hemoglobin

    IV. Reactions of Hemoglobin

    V. Oxidation-Reduction Equilibria

    VI. Some Considerations of Structure-Function Relationships in Hemoglobin


    Chapter 18. The Metabolism of Methemoglobin in Human Erythrocytes

    I. Introduction

    II. Definition of Methemoglobin

    III. Historical Review

    IV. Oxidation of Hemoglobin to Methemoglobin

    V. Protection Against Oxidation of Hemoglobin

    VI. Reduction of Methemoglobin to Hemoglobin

    VII. The Methemoglobin Reductases of Human Erythrocytes

    VIII. Biological Effects of Methemoglobin

    IX. Conclusion


    Chapter 19. Interaction of Oxygen and Carbon Dioxide with Hemoglobin at the Molecular Level

    I. Hemoglobin: Structural Features Essential for Oxygen Transport

    II. Conformational Changes Associated with Oxygenation

    III. Regulation of Oxygen Affinity: Bohr Effect and Organic Phosphates

    IV. Carbon Dioxide Transport

    V. Conclusion


    Chapter 20. Physiological Role of the Oxyhemoglobin Dissociation Curve

    I. Introduction

    II. Role of the Blood in Oxygen Transport and Oxygen Delivery

    III. The Link Between Blood and Oxygen Delivery: The Oxyhemoglobin Dissociation Curve

    IV. In Vivo Evidence for a Physiological Role of the Oxyhemoglobin Dissociation Curve

    V. Conclusion


    Chapter 21. The Hemoglobinopathies

    I. Introduction

    II. Hemoglobin Variants in Different Populations

    III. Types of Structural Alterations in Hemoglobin

    IV. Acquired Abnormalities of Hemoglobin

    V. Sickle Cell Hemoglobin and Its Interactions with Other Hemoglobins

    VI. Hemoglobins C and E

    VII. Congenital Heinz Body Hemolytic Anemias—Hemoglobin Variants That Are Unstable

    VIII. Erythrocytosis and Cyanosis—Hemoblogin Variants That Have Altered Ligand Affinity

    IX. Rare Hemoglobin Variants That Lack Clinical Expression in the Heterozygous State


    Chapter 22. The Thalassemia Syndromes

    I. Introduction

    II. The Genetics of the Thalassemia Syndromes

    III. Hemoglobin Synthesis in Thalassemia

    IV. Clinical Manifestations of the Thalassemia Syndromes

    V. Summary


    Chapter 23. Red Cell Genetic Polymorphisms: Their Usefulness in Some Studies of Human Biology

    I. Introduction

    II. Genetic Polymorphism

    III. Inherited Variation in Red Cell Components

    IV. Biological Studies Using Genetic Markers

    V. Conclusion


    Chapter 24. The Biological Life of the Red Cell

    I. Introduction

    II. The Red Cell in the Bone Marrow

    III. The Circulating Red Blood Cell

    IV. Values in Normal Man and in Animals

    V. Physical and Chemical Changes with Aging in Circulating Red Cells

    VI. Mechanisms of Red Cell Sequestration

    VII. The Catabolic Products of Red Blood Cells

    VIII. Determinants of the Red Blood Cell Life Span

    IX. Role of the Spleen

    X. Role of Metabolic Rate

    XI. Abnormal Hemoglobins

    XII. Extracorpuscular Factors

    XIII. Blood Loss—Iron Deficiency

    XIV. Neoplastic Diseases

    XV. Physical Factors

    XVI. Summary and Conclusions


    Chapter 25. Clinical Indications for Red Cells and Blood

    I. Introduction

    II. Blood Component Therapy

    III. Clinical Considerations


    Chapter 26. Biophysical Behavior of Red Cells in Suspensions

    Glossary of Symbols

    I. Basic Rheological Principles

    II. Flow Properties of Whole Blood

    III. Influence of Cell Concentration on the Rheology of Suspensions

    IV. Deformation of Red Cells in Suspensions

    V. Aggregation of Red Cells in Suspensions

    VI. Interaction of Factors Affecting Blood Viscosity

    VII. Blood Rheology, Blood Flow, and Oxygen Transport

    VIII. Physiological Variations in Blood Viscosity

    IX. Blood Rheology in Disease

    X. Summary


    Chapter 27. Electrokinetic Behavior of Red Cells

    Glossary of Symbols

    I. Introduction

    II. Electrokinetic Theory

    III. Equipment and Experimental Procedures

    IV. Surface Charge Properties of Red Blood Cells

    V. Eleetrokinetic-Mediated Behavior of the Cell with Its Environment


    Chapter 28. The Erythrocyte as a Biopsy Tissue in the Evaluation of Nutritional Status

    I. General Introduction

    II. Direct Evaluation by Assay of Nutrient Content of Red Cells

    III. Indirect Assessment of Nutritional Status by Measuring the Activity of a Vitamin-Containing Holoenzyme in Red Cells

    IV. Summary


    Chapter 29. New Knowledge of Red Cell Punne and Pyrimidine Metabolism Coming from the Study of Human Disease

    I. Introduction

    II. Purine Metabolism in Lesch-Nyhan Syndrome and Gout

    III. Pyrimidine Metabolism in Orotic Aciduria

    IV. 5-Phosphoribosyl-1-Pyrophosphate

    V. Transport of Purines and Pyrimidines


    Chapter 30. Parasitism and the Red Blood Cell

    I. Introduction

    II. Biochemistry of the Malaria Parasites

    III. Molecular Interactions Between Malaria Parasites and Their Red Cell Hosts

    IV. Genetics and Malaria Parasites

    V. Conclusions and the Future

    VI. Appendix: The Parasites and Their General Features


    Chapter 31. Drugs, Hormones, and the Red Cells

    I. Introduction

    II. General Comments

    III. Effects of Hormones on Red Cell Metabolism, Function, and Survival

    IV. Effects of Drugs on Red Cell Survival and Function, and on the Red Cell Membrane


    Index to Volumes I and II

Product details

  • No. of pages: 782
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 28, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9781483257501

About the Editor

Douglas MacN. Surgenor

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