The Red Blood Cell

The Red Blood Cell

2nd Edition - January 28, 1974

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  • Editor: Douglas Surgenor
  • eBook ISBN: 9780323161480

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The Red Blood Cell, Second Edition, Volume I provides information pertinent to red blood cells, which is the most intensely studied human tissue. This book reviews the basic biomedical knowledge about the circulating, red blood cells. Organized into 13 chapters, this edition starts with an overview of the discovery of red blood cells, which results in the growth of knowledge in the areas of clinical disease and therapeutic efforts. This book then discusses the significant functions of the red blood cells, which exists basically to transport the respiratory gases. Other chapters examine the red blood cell’s capacity for protein synthesis and its ability to diversify its function. This book discusses as well the progress in the structural analysis of lipids. The final chapter deals with the capacity to store red blood cells frozen for long periods with high yield of viable physiological functional cells after post-thaw processing. Scientists, physicians, teachers, researchers, and students will find this book extremely useful.

Table of Contents

  • List of Contributors


    Contents of Volume II

    Chapter 1. Historical Introduction

    I. Forethoughts

    II. Early Discovery and Experimentation

    III. Production of the Red Blood Cell

    IV. Functions of the Red Blood Cell

    V. Analytical Measures of Clinical Importance

    VI. Transfusion of Red Cells

    VII. Immunology

    VIII. Preservation and Anticoagulants

    IX. Conclusions and Futuristic Thoughts


    Chapter 2. Erythropoiesis

    I. Introduction

    II. The Hemopoietic Stem Cell

    III. Erythropoiesis in the Embryo

    IV. Regulation of Erythropoiesis and Hemoglobin Synthesis

    V. Genetics of Erythropoiesis and Globin Synthesis

    VI. Globin mRNA and the Synthesis of Hemoglobin

    VII. Summary


    Circulating Adult Red Cells

    Chapter 3. Composition of Normal Human Red Cells

    I. Introduction

    II. Components of the Erythrocyte Membrane

    III. Variants of Erythrocyte Components

    IV. Appendix (Tables II-XIII)


    Chapter 4. Lipids of the Red Cell Membrane

    I. General Introduction

    II. Chemical Composition of Red Cell Lipids

    III. Dynamic Aspects of Red Cell Lipids

    IV. Molecular Organization and Functions of Lipids in the Erythrocyte Membrane

    V. Abnormalities in Red Cell Lipids


    Chapter 5. The Morphology of Adult Red Cells

    I. Introduction and Scope of the Chapter

    II. Red Cell Shape

    III. Red Cell Dimensions

    IV. Electron Microscopy of Red Cells

    V. Cytoplasmic Ultrastructure

    VI. Red Cell Membrane Ultrastructure

    VII. Membrane-Cytoplasm Relationships


    Chapter 6. Dysfunctions of the Red Cell Membrane

    I. Introduction

    II. Defective Membrane Proteins in Hereditary Spherocytosis

    III. Abnormal Membrane Cholesterol Kinetics in Acanthocytosis

    IV. Other Rare Syndromes with Altered Red Cell Membrane Lipids

    V. Red Cell Membrane Alteration by Heinz Body Attachment

    VI. Increased Membrane Cation Permeability in Hemolytic Diseases


    Chapter 7. Blood-Group Substances: Their Nature and Genetics

    I. Introduction

    II. ABO and Lewis Groups

    III. MNSs Groups

    IV. Blood-Group P1 Substance

    V. The Rho(D) Antigen

    VI. Concluding Remarks


    Chapter 8. The Red Cell and Blood Coagulation Systems

    I. Introduction

    II. Red Cells: Rheology and Hemostasis

    III. Red Cells: Platelets and Hemostasis

    IV. Red Cells and Coagulation Reactions

    V. The Clinical Implications of Red Cell Procoagulants

    VI. Summary and Further Explanation



    Chapter 9. General Red Cell Metabolism

    I. Introduction

    II. Phylogenetic Considerations

    III. Red Cell Maturation

    IV. The Pathways and Enzymes of the Red Cell

    V. Senescence of the Red Cell

    VI. Concluding Remarks


    Chapter 10. Pentose Phosphate Metabolism

    I. Introduction

    II. General Features of the Pentose Shunt

    III. Functions of the Pentose Shunt

    IV. Regulation of the Pentose Shunt

    V. Enzymes of the Pentose Shunt

    VI. The Pentose Shunt and Red Cell Oxidation-Reduction Reactions

    VII. Interactions of the Pentose Shunt with the Embden-Meyerh of Pathway

    VIII. Pentose Phosphate Metabolism and Red Cell Aging

    IX. Glucose-6-Phosphate Dehydrogenase Deficiency

    X. Deficiencies Affecting the Remainder of the Pentose Shunt

    XI. Conclusion


    Chapter 11. Red Cell Metabolism and Function

    I. Introduction

    II. The Functions and Interaction s of Important Red Cell Metabolites

    III. Red Cell Glycolytic Control and Red Cell Function

    IV. In Vivo Evaluation of Red Cell Glycolysis Using Assay of Glycolytic Intermediates

    V. The Effects of Age, Sex, and Inheritance on Red Cell Metabolism and Function

    VI. The Future—Can Red Cell Metabolism Be Manipulated for Therapeutic Purpose's



    Chapter 12. Liquid and Freeze Preservation of Human Red Blood Cells

    I. Introduction

    II. Preservation Injury

    III. Measurement of Nonviable Red Cells

    IV. Life Span of Preserved Viable Red Cells

    V. Function of Circulating Red Cells

    VI. Salvaging and Rejuvenation of Outdated Red Cells and Red Cells with Elevated 2,3-DPG Levels and Decreased Affinity for Oxygen

    VII. Index of Therapeutic Effectiveness

    VIII. Containers and Filters

    IX. Liquid Preservation Techniques

    X. Concentrated Red Cells from Liquid Blood

    XI. Physiology of Washing Liquid and Previously Frozen Red Cells

    XII. Freezing Techniques

    XIII. Evaluation of Current Methods

    XIV. Transportability

    XV. Standardization of the Red Cell Washing Procedure to Remove Glycerol

    XVI. Homologous versus Autologous Transfusions

    XVII. Justification and Cost of Freezing Methods

    XVIII. Future of Frozen Blood Banking

    XIX. Component Theory


    Chapter 13. Cryobiology of the Red Blood Cell

    I. Introduction

    II. Slow Freezing: The Mechanism of Injury

    III. Penetrating Cryoprotectants

    IV. Extracellular Cryoprotectants

    V. Practical Red Cell Freezing


    Chapter 14. The Appropriate Role for Red Cell Freezing in Transfusion Practice

    I. Historical Introduction

    II. The Current Polarization of Opinion

    III. Examination of the Arguments Favoring Widespread Application of Frozen Storage

    IV. Arguments against Widespread Application of Frozen Storage

    V. Conclusions



Product details

  • No. of pages: 628
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 28, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9780323161480

About the Editor

Douglas Surgenor

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