The Receptors

Contributors

Preface

Contents of Previous Volumes

Chapter 1 Secretory Component: The Receptor That Mediates External Secretion of Polymeric Immunoglobulins

I. Introduction

II. Synthesis of IgA-J-Chain Polymers and Their Migration to Secretory Component-Containing Secretory Cells (Epithelial Cells and Hepatocytes)

III. Molecular Structure and Biosynthesis of Secretory Component

IV. Tissue Distribution of Secretory Component

V. Secretory Component-Dependent Binding, Transport, and Exocytosis of Polymeric Immunoglobulin

VI. Summary

References

Chapter 2 Interferon Receptors

I. Introduction

II. Direct Analysis of the Interaction of Interferons with Membrane Receptors 57

III. Nature and Structure of Interferon Receptors

IV. Fate of Cell-Bound Interferons

V. Conclusions

References

Chapter 3 Protein Tyrosine Kinase Activity of Hormone and Growth Factor Receptors

I. Introduction

II. Epidermal Growth Factor Receptor

III. Platelet-Derived Growth Factor Receptor

IV. Insulin Receptor

V. Insulinlike Growth Factor I Receptor

VI. Inhibitors of Protein Tyrosine Kinases

VII. Substrate Specificity of the Growth Factor-Stimulated Protein Tyrosine Kinases

VIII. Physiological Role of Tyrosine Phosphorylation: Fact and Speculation

IX. Interaction of the Growth Factor-Stimulated Kinases with Other Hormone-Regulated Kinases

X. Concluding Remarks

References

Chapter 4 Muscimol and Central Nervous System γ-Aminobutyric Acid Receptors: Studies with Ligand-Binding Techniques

I. Introduction

II. Effects of Muscimol on GABA Binding of CNS Subcellular Particles

III. Constants for [3H]Muscimol Binding to CNS Subcellular Particles

IV. Substrate Specificity of [3H]Muscimol Binding

V. CNS Regional and Subcellular Differences in Muscimol Binding

VI. Some Factors That Affect [3H]Muscimol Binding

VII. [3H]Muscimol Binding to Solubilized Receptors

VIII. [3H]Muscimol Binding to Blood Vessels of the CNS

IX. [3H]Muscimol Binding to Subcellular Particles Prepared from Tissue Cultures

X. Comparison of Muscimol Receptors and GABA Receptors

XI. Recent Studies of [3H]Muscimol Binding in Relation to Physiology, Behavior, and Neurologic-Psychiatric Disorders of Man

XII. Concluding Comments

References

Chapter 5 Protease Nexins: Secreted Protease Inhibitors That Regulate Protease Activity at or near the Cell Surface

I. Introduction

II. The Thrombin and Urokinase-Binding Protease Nexin: PN or PN-1

III. PN-2

IV. PN-3

V. Summary

References

Chapter 6 Receptor Regulation of Phosphoinositides and Calcium: A Mechanism for Thyrotropin-Releasing Hormone Action

I. Introduction

II. Calcium and TRH Action

III. Stimulation of Phospholipid Metabolism

IV. Initial Studies of the Effects of TRH on Phospholipid Metabolism

V. Effects of TRH on Polyphosphoinositide Metabolism

VI. TRH-Induced Phospholipase C Hydrolysis of PtdIns4,5P2: Calcium Dependent or Independent

VII. InsP3 and DG as Intracellular Mediators

VIII. Model of TRH Action

References

Chapter 7 Phospholipid Turnover and Receptor Function

I. Phospholipids as Receptors

II. Phospholipid Methylation and Receptor Activation

III. Direct Activation of Plasma Membrane Phospholipase A2 by Ligands

IV. Phosphoinositides in Receptor Activation

V. Inhibition by Vasopressin of Plasma Membrane Ca2+, Mg2+-ATPase

VI. Cellular Proliferation and Phosphoinositide Turnover

VII. Relationship between Na+, Ca2+, and Phosphoinositide Breakdown

VIII. Conclusion

References

Chapter 8 The Tuftsin Receptors

I. Introduction

II. Synthesis of Radiolabeled Tuftsin

III. Binding of [3H]Tuftsin to Phagocytic Cells

IV. Binding of Tuftsin to Lymphocytes

V. Binding of Tuftsin to Various Cells

VI. Dynamics of Tuftsin Receptors

VII. Are Membrane-Associated Events Relevant to Tuftsin's Action?

VIII. Receptors for Tuftsin on Plasma Membranes of Macrophages and Macrophagelike Cells

IX. On the Relation Between Tuftsins and Fc Receptors

X. Toward Isolation of Purified Soluble Tuftsin Receptor

XI. Tuftsin and the Chemotactic Peptide Receptors: Some Mutual Considerations

XII. The Tuftsin Receptors: A Multifunctional Homogeneous or Heterogeneous Population

References

Chapter 9 Somatomedin Receptors: Structure, Function, and Regulation

I. Somatomedin: Background

II. Somatomedin Receptors: Discovery and Diversity

III. Structural Analysis of Somatomedin Receptors

IV. Immunological Studies of Somatomedin Receptors

V. Regulation of Somatomedin Receptors

VI. Role of the Somatomedin Receptor in Somatomedin and Insulin Action

References

Chapter 10 The Internalization and Intracellular Processing of Insulin Receptors

I. Introduction

II. Internalization of Insulin Receptors

III. Recycling of Insulin Receptors

IV. Degradation of Insulin Receptors

V. Functional Significance of the Internalization and Processing of Insulin Receptors

VI. Summary

References

Chapter 11 The Prolactin Receptor

I. Introduction

II. General Characteristics of the Prolactin Receptor

III. Biochemical Characterization of the Prolactin Receptor

IV. Prolactin Receptor Antibodies

References

Chapter 12 Nicotine Receptors in the Central Nervous System

I. Introduction

II. Pharmacological Evidence for Central Nicotine Receptors

III. In Vitro Characterization of the Nicotine Receptors

IV. Central Localization of Receptors

V. Functional Role of Nicotine Receptors

References

Index