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The Quinolones
1st Edition - November 1, 1988
Editor: Vincent T. Andriole
Language: English
eBook ISBN:9781483216034
9 7 8 - 1 - 4 8 3 2 - 1 6 0 3 - 4
The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug…Read more
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The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug interactions, and future prospects of the 4-quinolones. The book discusses the microbiology of quinolones, particularly with consideration of the development of resistance, pharmacology, toxicology, and clinical uses. Chemists, microbiologists, pharmacologists and clinicians will find the book useful.
Contributors
Preface
1 The Quinolones: History and Overview
1.1 Mechanism of Action
1.2 Activity In Vitro
1.3 Bacterial Resistance
1.4 Clinical Pharmacology
1.5 Clinical Uses
1.5.1 Genitourinary and Gastrointestinal Infections
1.5.2 Respiratory Tract Infections
1.5.3 Skin and Bone Infections
1.5.4 Other Infections
1.6 Adverse Effects
1.7 Summary
References
2 Chemistry and Mechanisms of Action of the Quinolone Antibacterials 23
2.1 Chemistry
2.2 Target Site
2.3 Selectivity
2.4 Antibacterial Activities
2.5 4-Quinolone Interactions with Ions
2.6 4-Quinolone Interactions with Oxygen
2.7 4-Quinolone Interactions with Other Antibacterials
2.8 Resistance
References
3 In Vitro Properties of the Quinolones
3.1 Gram-Negative Aerobes
3.1.1 Enterobacteriaceae
3.1.2 Other Gram-Negative Aerobes
3.2 Gram-Positive Aerobes
3.3 Anaerobes
3.4 Miscellaneous Organisms
3.5 Development of Resistance
3.6 Conclusion
References
4 Pharmacokinetics of Fluorinated Quinolones
Introduction
4.1 Serum Concentrations
4.2 Urine Concentrations
4.3 Steady State
4.4 Pharmacokinetics
4.5 Elimination
4.6 Bioavailability
4.7 Impaired Renal Function
4.8 Impaired Liver Function
4.9 Impact of Food
4.10 Interactions
4.11 Influence of Disease
4.12 Extravascular Penetration
References
5 Clinical Overview of the Newer 4-Quinolone Antibacterial Agents