The Pulmonary Circulation in Health and Disease

1st Edition - January 28, 1987
Editor: James Will
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 5 2 3 - 7

The Pulmonary Circulation in Health and Disease covers the proceedings of a symposium purposed to create a more complete picture of the pulmonary circulation under normal and… Read more

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The Pulmonary Circulation in Health and Disease covers the proceedings of a symposium purposed to create a more complete picture of the pulmonary circulation under normal and diseased conditions through the help of an interdisciplinary group of acknowledged experts. The book is divided into seven parts. The first part discusses morphology in relation to pulmonary circulation and includes an overview of the microscopic appearance of the pulmonary artery and the innervation of the pulmonary circulation, as well as the structure and infrastructure of the pulmonary microvasculature and the changes it undergoes. The second part concerns itself with the different pharmacological studies related to pulmonary circulation. The third part goes in-depth about concepts in pulmonary hemodynamics, such as its occlusion methods, its models based on anatomic and functional data, its active distribution, and gravity nondependent distribution of pulmonary blood flow; the fourth part on the other hand discusses pulmonary blood flow and gas exchange. The fifth part discusses pulmonary endothelial cells, its mechanisms, and its properties; the sixth and seventh parts cover the mechanisms of pulmonary hypertension. The text is recommended for basic scientists studying the lung and for clinicians such as cardiologists and pulmonologists. Those interested in the effects of alterations in lung function will also find this helpful.

Contents

Preface

Acknowledgments

Morphology

An Overview of the Microscopic Appearance of the Pulmonary Artery and the Problems of Its Quantitation

Innervation of the Pulmonary Circulation: An Overview

The Pathology of Human Pulmonary Hypertension Pattern Recognition and Specificity

The Structure and Ultrastructure of the Pulmonary Microvasculature

The Pulmonary Vasculature and Experimental Pulmonary Hypertension in Animals

Pulmonary Vascular Changes in Infants and Children

Summary: The Morphology of the Pulmonary Vasculature

Pharmacology

Pharmacology of the Pulmonary Circulation: Introduction

Pharmacology of the Pulmonary Circulation: An Overview

Vascular Smooth Muscle Metabolism and Mechanisms of Oxygen Sensing

Pharmacological Studies of Contractile and Relaxant Responses to Serotonin in Extralobar Pulmonary Arteries Isolated from the Guinea Pig

Pulmonary Vascular Responses to Eicosanoids

Relationship of Pharmacologic Agents, Pulmonary Endothelial cells and Pulmonary Circulation

Pharmacology of the Pulmonary Circulation: Summary

Hemodynamics

Pulmonary Hemodynamics: Introduction

Pulmonary Microvascular Hemodynamics: Occlusion Methods

Models of the Pulmonary Hemodynamics Based on Anatomic and Functional Data

Interpretation of Pressure-Flow Curves in the Pulmonary Vascular Bed

Gravity Nondependent Distribution of Pulmonary Blood Flow

Active Regulation of the Pulmonary Circulation: A Model for Hypoxic Pulmonary Vasoconstriction

Pulmonary Hemodynamics: Summary

Pulmonary Blood Flow and Gas Exchange

Pulmonary Blood Flow and Gas Exchange: Introduction

Pulmonary Blood Flow and Gas Exchange: An Overview

Gas Exchange in Pulmonary Vascular Disease

Pulmonary Circulation in Exercise

Effects of Hypoxic Vasoconstriction on the Mechanical Interaction between Pulmonary Vessels and Airways

Vasomotor Tone and Optimization of Gas Exchange

Endothelial Function

The Pulmonary Endothelium: Summary

Pulmonary Endothelial Cells

Mechanisms of Lung Endothelial Injury

Regulation of Transport and Permeability Properties of Pulmonary Endothelium

Interactions of Anaphylatoxins with Endothelium

Hemostatic Potential of the Pulmonary Endothelium

Mechanisms of Pulmonary Hypertension

Mechanisms of Pulmonary Hypertension, 1986: Introduction

Mechanisms of Pulmonary Hypertension: An Overview

Pulmonary Hypertension in the Presence of High Blood Flow

Persistent Pulmonary Hypertension Syndromes in the Newborn

Potential Mechanisms of Hypoxic Pulmonary Vasoconstriction

Mechanisms of Control of the Perinatal Pulmonary Circulation

Summary

Clinical Pulmonary Hypertension

Clinical Pulmonary Hypertension: Introduction

Clinical Pulmonary Hypertension: An Overview

Epidemiologic and Clinical Characteristics of Primary Pulmonary Hypertension

Diagnosis and Long-Term Management of Venous Thromboembolism

Management of Chronic Unresolved Large Vessel Thromboembolism

Exogenous Influences on the Initiation and Course of Pulmonary Hypertension

Index