The Proteins Composition, Structure, and Function V2

The Proteins Composition, Structure, and Function V2

2nd Edition - January 1, 1964

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  • Editor: Hans Neurath
  • eBook ISBN: 9780323161305

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Description

The Proteins: Composition, Structure, and Function, Second Edition, Volume II deals with fundamental properties of proteins, both in solution and in the solid state. This volume consists of five chapters that specifically cover the advances in understanding the structure and function of the protein molecule. The opening chapter presents interpretative procedures of experimental methods for determining protein conformation using X-ray crystallography, followed by an examination of the acid-base dissociations of proteins. The discussion then shifts to the investigation of interactions between protein molecules and other macromolecules, which is of significant importance in providing a chemical basis for many biological processes. A chapter considers first the synthesis, purification, and chemical properties of the polyamino acids. This chapter further describes their physicochemical properties in the solid state, in solution, and at interfaces, and lastly discusses their biological properties as high molecular weight substrates for proteolytic enzymes and as synthetic antigens, and their interaction with proteins and nucleic acids, with viruses, bacteria, blood components, and other biological systems. The use of polyamino acids in the study of the genetic code and the preparation and properties of polypeptidyl proteins are also covered. The concluding chapter focuses on X-ray analysis of protein structure. Organic chemists, biochemists, and researchers in protein-related fields will find this book invaluable

Table of Contents


  • List of Contributors

    Preface

    Contents of Volume I

    Contents of Volume III

    Contents of Volume IV

    Contents of Volume V

    Errata

    Chapter 7 The Conformation of Polypeptide Chains in Proteins

    I. Introduction

    II. Possible Conformations of the Polypeptide Chain in Solution

    III. Summary of Results Obtained from Investigations of Synthetic Polypeptides

    IV. Experimental Methods of Determining the Conformation of Proteins

    V. Conclusion

    References

    Chapter 8 Interaction of Proteins with Hydrogen Ions and Other Small Ions and Molecules

    I. Introduction

    II. Definitions, Concepts, and Experimental Methods

    III. Prototropic Components and Their Characteristics

    IV. Description of Useful Models

    V. Experimental Results with Individual Proteins and Their Interpretation

    VI. Binding of Small Ions to Proteins

    VII. Combination of Proteins with Un-ionized Molecules

    VIII. Applications of Protein Acid-Base Equilibria

    IX. Problem Areas for Future Investigations

    References

    Chapter 9 Interacting Protein Systems

    I. Introduction

    II. Methods for Obtaining Values of Characteristic Parameters

    III. The Behavior of Interacting Systems in Transport Experiments

    IV. Interaction Effects in Other Physicochemical Measurements

    References

    Chapter 10 Polyamino Acids as Protein Models

    I. Introduction

    II. Synthesis and Chemical Properties of Polyamino Acids

    III. Conformation of Polyamino Acids in the Solid State

    IV. Properties of Polyamino Acids in Solution

    V. Monomolecular Layers

    VI. Polyamino Acids as Substrates for Proteolytic Enzymes

    VII. Polypeptidyl Enzymes and Water-Insoluble Enzymes

    VIII. Antigenicity of Polyamino Acids and Polypeptidyl Proteins

    IX. Polyamino Acids in the Study of the Genetic Code

    X. Interaction of Polyamino Acids with Enzymes and Other Proteins and with Nucleic Acids

    XI. Interaction of Polyamino Acids with Viruses, Bacteria, Fungi, and Blood Cells

    XII. Other Studies of Biological Interest

    XIII. Concluding Remarks

    References

    Chapter 11 X-Ray Analysis and Protein Structure

    I. Introduction

    II. Globular Proteins

    III. Fibrous Proteins

    Bibliography

    References

    Author Index

    Subject Index


Product details

  • No. of pages: 856
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9780323161305

About the Editor

Hans Neurath

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