Thanks to a resurgence of interest and a recent proliferation of research techniques, much new and illuminating data has emerged during the last decade relating to the prefrontal cortex, particularly in primates and rodents. In view of this progress, the 16th International Summer School of Brain Research was held in Amsterdam, The Netherlands from 28 August to 1 September 1989, devoted to the topic of `The Prefrontal Cortex: Its Structure, Function and Pathology'. The edited proceedings, embodied in this 85th volume of `Progress in Brain Research', fall into three sections - the first of which, following two introductory chapters, discusses the present knowledge of the organization of prefrontal cortical systems. In the second section, developmental and plasticity aspects in rodent and human cortex are considered, whilst the third section deals extensively with the functional aspects characteristic for the prefrontal cortex in primates, rats and rabbits. The last section reviews several topics on dysfunction of prefrontal cortex in rat and man, including a historical review on psychosurgery.

Table of Contents

List of contributors. Preface. Acknowledgements. Section I: Organization of Prefrontal Cortical Systems. 1. How sensory cortex is subdivided in mammals: implications for studies in prefrontal cortex (J.H. Kaas). 2. Neurotransmitters in the cerebral cortex (J.G. Parnavelas). 3. Qualitative and quantitative comparison of the prefrontal cortices in rat and in primates, including humans (H.B.M. Uylings and C.G. van Eden). 4. Prefrontal cortex in relation to other cortical areas in rhesus monkey: architecture and connections (D.N. Pandya and E.H. Yeterian). 5. The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: evidence for a parallel organization (H.J. Groenewegen, H.W. Berendse, J.G. Wolters and A.H.M. Lohman). 6. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, `prefrontal' and `limbic' functions (G.E. Alexander, M.D. Crutcher and M.R. DeLong). 7. Prefrontal cortical control of the autonomic nervous system: anatomical and physiological observations (E.J. Neafsey). Section II: Development and Plasticity in Prefrontal Cortex. 8. The development of the rat prefrontal cortex. Its size and development of connections with thalamus, spinal cord and other cortical areas (C.G. van Eden, J.M. Kros and H.B.M. Uylings). 9. Neuronal development in human prefrontal cortex in prenatal and postnatal stages (L. Mrzljak, H.B.M. Uylings, C.G. van Eden and M. Judás). 10. Structural and histochemical reorganization of the human prefrontal cortex during perinatal and postnatal life (I. Kostovici). 11. Anatomical correlates of behavioural change after neonatal prefrontal lesions in rats (B. Kolb and R. Gibb). 12. Age-dependent effects of lesioning the mesocortical dopamine system upon prefrontal cortex morphometry and PFC-related behaviours (A. Kalsbeek, J.P.C. de Bruin, M.G.P. Feenstra and H.B.M. Uylings). 13. Is it possible to repair the damaged prefr


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© 1990
Elsevier Science
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