The Porphyrins V7

Biochemistry, Part B

1st Edition - July 28, 1979
Editor: David Dolphin
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 5 6 1 - 9

The Porphyrins, Volume VII: Biochemistry, Part B is devoted to the biochemistry of porphyrins, their precursors, and related compounds. The book covers the structure and function… Read more

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The Porphyrins, Volume VII: Biochemistry, Part B is devoted to the biochemistry of porphyrins, their precursors, and related compounds. The book covers the structure and function of the major heme proteins and their reconstitution and metal substitution, along with proteins derived from green photosynthetic bacteria. This volume is organized into 11 chapters and begins with an introduction to the cytochrome oxidase, paying particular attention to its isolation and characterization as well as biosynthesis. The discussion then turns to the electron transfer functions of cytochromes b and c; the structure of cytochrome c; and the proposed structures for peroxidases, catalases, and chloroperoxidase. The following chapters explore the biochemical mechanism and control of the catalytic function of cytochrome P-450 and associated electron transport chains, metal substitution in hemoglobin and myoglobin, and reconstitution experiments on various hemoproteins with particular attention to the removal of heme and reassembly into a heme-protein complex, along with protein folding around the heme. This book will be of interest to inorganic, organic, physical, and biochemists involved in the study of the biochemistry of porphyrins.

List of Contributors

General Preface

Preface

Contents of Other Volumes

1 Cytochrome Oxidase

I. Historical Perspective

II. Oxidase Isolation and Characterization

III. Biosynthesis of Cytochrome c Oxidase

IV. Electron Paramagnetic Resonance Absorption of Cytochrome c Oxidase

V. Inhibitors of Cytochrome c Oxidase

VI. Reaction of Molecular Oxygen with Cytochrome c Oxidase

VII. Cytochrome Oxidase-Cytochrome c Interaction

VIII. Cytochromes a and a3

IX. Interactions between the Components of Cytochrome c Oxidase and ATP Hydrolysis

X. Role of Cytochrome c Oxidase in Oxidative Phosphorylation

XL. Bacterial Oxidases

References

2 Cytochrome b in Energy-Transducing Membranes

I. Introduction

II. Historical Background

III. Chemical and Biochemical Data

IV. Spectral and Redox Properties in Situ

V. Position and Function of Cytochrome b in the Electron Transport Chain

VI. Conclusions

References

3 The X-Ray Crystallographic Structure of Calf Liver Cytochrome b5

I. Introduction

II. Crystal Structure Analysis

III. Conformation of the Molecule

IV. Reduced Cytochrome b5

V. Discussion

VI. Summary

References

4 The Electron Transfer Function of Cytochrome c

I. Introduction and History

II. Functional Significance of Evolutionary Changes of Cytochrome c Structure

III. Chemical Modifications of Cytochrome c

IV. Nonphysiological Redox Reactions

V. Reactions of Cytochrome c with Enzyme Systems

VI. Conclusions

References

5 Cytochrome c: The Architecture of a Protein-Porphyrin Complex

I. Introduction

II. Structural Considerations

III. Mechanistic Considerations

IV. Conclusions and Some Speculations

References

6 Peroxidases, Catalases, and Chloroperoxidase

I. Introduction

II. Native Enzymes

III. Oxidation-Reduction States of Peroxidase

IV. Relation of Compound ES to Compound I

V. Chemical Composition of Compound I

VI. Kinetic Studies on the Formation and Decomposition of Compounds I and II

VII. Catalases

VIII. Possible Relationship between Peroxidase Compound I and the P-450 Hydroxylating Intermediate

References

7 Cytochrome P-450: Biophysical Properties and Catalytic Function

I. Introduction

II. Historical Overview

III. Protein Structure and Heme Environment of Cytochrome P-450

IV. Properties and Function of the Resolved Electron Transfer Components Associated with Cytochrome F-450 Monooxygenase Systems

V. Mechanism of Catalysis

VI. Summary

References

8 Reconstitution of Hemoproteins

I. Introduction

II. Classification of Hemoproteins on the Basis of Their Prosthetic Group

III. Hemoglobins

IV. Myoglobin

V. Catalase

VI. Peroxidase

VII. Cytochromes

VIII. Heme-Containing Oxygenases

IX. Concluding Remarks

References

9 Metal Substitution in Hemoglobin and Myoglobin

I. Introduction

II. Nomenclature

III. Preparation

IV. Cobalt

V. Manganese

VI. Porphyrin

VII. Zinc

VIII. Other Metals

IX. Allosteric Mechanism

References

10 Hemoglobin and Myoglobin

I. Introduction

II. Structure of Myoglobin and Hemoglobin

III. Mechanism of Cooperative Ligand Binding in Hemoglobin

References

11 Bacteriochlorophyll-Proteins from Green Photosynthetic Bacteria

I. Introduction

II. Water-Soluble Bacteriochlorophyll-Proteins

III. Reaction-Center Complexes

IV. X-Ray Crystallographic Studies of a Bacteriochlorophyll-Protein

V. Structural Inferences

References

Author Index

Subject Index