The Porphyrins V7 - 1st Edition - ISBN: 9780122201073, 9780323145619

The Porphyrins V7

1st Edition

Biochemistry, Part B

Editors: David Dolphin
eBook ISBN: 9780323145619
Imprint: Academic Press
Published Date: 28th July 1979
Page Count: 572
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The Porphyrins, Volume VII: Biochemistry, Part B is devoted to the biochemistry of porphyrins, their precursors, and related compounds. The book covers the structure and function of the major heme proteins and their reconstitution and metal substitution, along with proteins derived from green photosynthetic bacteria. This volume is organized into 11 chapters and begins with an introduction to the cytochrome oxidase, paying particular attention to its isolation and characterization as well as biosynthesis. The discussion then turns to the electron transfer functions of cytochromes b and c; the structure of cytochrome c; and the proposed structures for peroxidases, catalases, and chloroperoxidase. The following chapters explore the biochemical mechanism and control of the catalytic function of cytochrome P-450 and associated electron transport chains, metal substitution in hemoglobin and myoglobin, and reconstitution experiments on various hemoproteins with particular attention to the removal of heme and reassembly into a heme-protein complex, along with protein folding around the heme. This book will be of interest to inorganic, organic, physical, and biochemists involved in the study of the biochemistry of porphyrins.

Table of Contents

List of Contributors

General Preface


Contents of Other Volumes

1 Cytochrome Oxidase

I. Historical Perspective

II. Oxidase Isolation and Characterization

III. Biosynthesis of Cytochrome c Oxidase

IV. Electron Paramagnetic Resonance Absorption of Cytochrome c Oxidase

V. Inhibitors of Cytochrome c Oxidase

VI. Reaction of Molecular Oxygen with Cytochrome c Oxidase

VII. Cytochrome Oxidase-Cytochrome c Interaction

VIII. Cytochromes a and a3

IX. Interactions between the Components of Cytochrome c Oxidase and ATP Hydrolysis

X. Role of Cytochrome c Oxidase in Oxidative Phosphorylation

XL. Bacterial Oxidases


2 Cytochrome b in Energy-Transducing Membranes

I. Introduction

II. Historical Background

III. Chemical and Biochemical Data

IV. Spectral and Redox Properties in Situ

V. Position and Function of Cytochrome b in the Electron Transport Chain

VI. Conclusions


3 The X-Ray Crystallographic Structure of Calf Liver Cytochrome b5

I. Introduction

II. Crystal Structure Analysis

III. Conformation of the Molecule

IV. Reduced Cytochrome b5

V. Discussion

VI. Summary


4 The Electron Transfer Function of Cytochrome c

I. Introduction and History

II. Functional Significance of Evolutionary Changes of Cytochrome c Structure

III. Chemical Modifications of Cytochrome c

IV. Nonphysiological Redox Reactions

V. Reactions of Cytochrome c with Enzyme Systems

VI. Conclusions


5 Cytochrome c: The Architecture of a Protein-Porphyrin Complex

I. Introduction

II. Structural Considerations

III. Mechanistic Considerations

IV. Conclusions and Some Speculations


6 Peroxidases, Catalases, and Chloroperoxidase

I. Introduction

II. Native Enzymes

III. Oxidation-Reduction States of Peroxidase

IV. Relation of Compound ES to Compound I

V. Chemical Composition of Compound I

VI. Kinetic Studies on the Formation and Decomposition of Compounds I and II

VII. Catalases

VIII. Possible Relationship between Peroxidase Compound I and the P-450 Hydroxylating Intermediate


7 Cytochrome P-450: Biophysical Properties and Catalytic Function

I. Introduction

II. Historical Overview

III. Protein Structure and Heme Environment of Cytochrome P-450

IV. Properties and Function of the Resolved Electron Transfer Components Associated with Cytochrome F-450 Monooxygenase Systems

V. Mechanism of Catalysis

VI. Summary


8 Reconstitution of Hemoproteins

I. Introduction

II. Classification of Hemoproteins on the Basis of Their Prosthetic Group

III. Hemoglobins

IV. Myoglobin

V. Catalase

VI. Peroxidase

VII. Cytochromes

VIII. Heme-Containing Oxygenases

IX. Concluding Remarks


9 Metal Substitution in Hemoglobin and Myoglobin

I. Introduction

II. Nomenclature

III. Preparation

IV. Cobalt

V. Manganese

VI. Porphyrin

VII. Zinc

VIII. Other Metals

IX. Allosteric Mechanism


10 Hemoglobin and Myoglobin

I. Introduction

II. Structure of Myoglobin and Hemoglobin

III. Mechanism of Cooperative Ligand Binding in Hemoglobin


11 Bacteriochlorophyll-Proteins from Green Photosynthetic Bacteria

I. Introduction

II. Water-Soluble Bacteriochlorophyll-Proteins

III. Reaction-Center Complexes

IV. X-Ray Crystallographic Studies of a Bacteriochlorophyll-Protein

V. Structural Inferences


Author Index

Subject Index


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© Academic Press 1979
Academic Press
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About the Editor

David Dolphin

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