The Plasma Proteins
Isolation, Characterization, and Function
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The Plasma Proteins, Volume I: Isolation, Characterization, and Function focuses on the reactions, properties, characteristics, and transformations of plasma proteins. The selection first offers information on the fractionation and isolation of purified components by precipitation methods and electrophoretic and ultracentrifugal analysis of normal human serum. Discussions focus on correlation of electrophoretic and ultracentrifugal results, electrophoretic analytical methodology and results, parameters influencing protein solubility, and techniques for the separation of proteins by precipitation methods. The text then ponders on the chromatography of plasma proteins and chemical composition and molecular parameters of purified plasma proteins. The manuscript elaborates on plasma albumin and macroglobulins and high molecular weight antibodies. Topics include immunological properties, physical and chemical properties of normal and pathological macroglobulins, purity, homogeneity, and variability, denaturation behavior, and sulfhydryl groups, mercaptalbumin, and the mercury dimer. The book then examines glycoproteins and metal-binding plasma proteins and cation transport. The selection is a highly recommended reference for biochemists and clinicians interested in plasma proteins.
Table of Contents
Contributors to Volume I
Contributors to Volume II
Preface
List of Tables in Volume I
Contents of Volume II
1. Introduction
I. Scope
II. Historical
III. Development of Physicochemical Instrumentation and of Inclusive Fractionation Procedures
IV. Recent Advances
V. Trends for the Future
References
2. Fractionation and Isolation of Purified Components by Precipitation Methods
I. Introduction
II. Parameters Which Influence Protein Solubility
III. Specific Techniques for Separation of Proteins by Precipitation Methods
References
Appendix
3. Electrophoretic and Ultracentrifugal Analysis of Normal Human Serum
I. Introduction
II. Electrophoretic Analytical Methodology and Results
III. Ultracentrifugal Analytical Methods
IV. Preparatory Methods
V. Correlation of Electrophoretic and Ultracentrifugal Results
References
4. Chromatography of the Plasma Proteins
I. Introduction
II. Adsorbents
III. Elution
IV. Examination of the Effluent
V. Applications
References
5. Chemical Composition and Molecular Parameters of Purified Plasma Proteins
I. Delineation of the Purified Plasma Proteins
II. Chemical Composition
III. Molecular Parameters
References
6. Plasma Albumin
I. Introduction
II. Purity, Homogeneity, and Variability
III. Amphoteric Behavior
IV. Ion-Binding Behavior
V. Sulfhydryl Groups, Mercaptalbumin, and the Mercury Dimer
VI. Behavior at Low pH
VII. Denaturation Behavior
VIII. Summary Discussion and Physiological Implications
References
7. γ-Globulin and Antibodies
I. Association of Antibodies with γ-Globulin
II. Physical Properties of γ-Globulin and Antibody
III. Chemical Properties
IV. Biological Properties
References
8. Macroglobulins and High Molecular Weight Antibodies
I. Introduction
II. 19 S Components of Normal Serum
III. Physical and Chemical Properties of Normal and Pathological Macroglobulins
IV. Immunological Properties
V. 19 S Antibodies
VI. Waldenström's Macroglobulinemia and Related Disorders
VII. Summary
References
9. Glycoproteins
I. Introduction
II. Nomenclature
III. Sugar Components in the Plasma Glycoproteins
IV. Multiplicity of the Plasma Glycoproteins
V. Chemical Structure of Plasma Glycoproteins
VI. Concluding Comments
References
10. Metal-Binding Plasma Proteins and Cation Transport
I. Introduction
II. Iron
III. Copper
IV. Zinc
V. Alkaline Earth Metals
References
Author Index
Subject Index
Product details
- No. of pages: 426
- Language: English
- Copyright: © Academic Press 1960
- Published: January 1, 1960
- Imprint: Academic Press
- eBook ISBN: 9781483258676