The Plasma Proteins

The Plasma Proteins

Isolation, Characterization, and Function

1st Edition - January 1, 1960

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  • Editor: Frank W Putnam
  • eBook ISBN: 9781483258676

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The Plasma Proteins, Volume I: Isolation, Characterization, and Function focuses on the reactions, properties, characteristics, and transformations of plasma proteins. The selection first offers information on the fractionation and isolation of purified components by precipitation methods and electrophoretic and ultracentrifugal analysis of normal human serum. Discussions focus on correlation of electrophoretic and ultracentrifugal results, electrophoretic analytical methodology and results, parameters influencing protein solubility, and techniques for the separation of proteins by precipitation methods. The text then ponders on the chromatography of plasma proteins and chemical composition and molecular parameters of purified plasma proteins. The manuscript elaborates on plasma albumin and macroglobulins and high molecular weight antibodies. Topics include immunological properties, physical and chemical properties of normal and pathological macroglobulins, purity, homogeneity, and variability, denaturation behavior, and sulfhydryl groups, mercaptalbumin, and the mercury dimer. The book then examines glycoproteins and metal-binding plasma proteins and cation transport. The selection is a highly recommended reference for biochemists and clinicians interested in plasma proteins.

Table of Contents

  • Contributors to Volume I

    Contributors to Volume II


    List of Tables in Volume I

    Contents of Volume II

    1. Introduction

    I. Scope

    II. Historical

    III. Development of Physicochemical Instrumentation and of Inclusive Fractionation Procedures

    IV. Recent Advances

    V. Trends for the Future


    2. Fractionation and Isolation of Purified Components by Precipitation Methods

    I. Introduction

    II. Parameters Which Influence Protein Solubility

    III. Specific Techniques for Separation of Proteins by Precipitation Methods



    3. Electrophoretic and Ultracentrifugal Analysis of Normal Human Serum

    I. Introduction

    II. Electrophoretic Analytical Methodology and Results

    III. Ultracentrifugal Analytical Methods

    IV. Preparatory Methods

    V. Correlation of Electrophoretic and Ultracentrifugal Results


    4. Chromatography of the Plasma Proteins

    I. Introduction

    II. Adsorbents

    III. Elution

    IV. Examination of the Effluent

    V. Applications


    5. Chemical Composition and Molecular Parameters of Purified Plasma Proteins

    I. Delineation of the Purified Plasma Proteins

    II. Chemical Composition

    III. Molecular Parameters


    6. Plasma Albumin

    I. Introduction

    II. Purity, Homogeneity, and Variability

    III. Amphoteric Behavior

    IV. Ion-Binding Behavior

    V. Sulfhydryl Groups, Mercaptalbumin, and the Mercury Dimer

    VI. Behavior at Low pH

    VII. Denaturation Behavior

    VIII. Summary Discussion and Physiological Implications


    7. γ-Globulin and Antibodies

    I. Association of Antibodies with γ-Globulin

    II. Physical Properties of γ-Globulin and Antibody

    III. Chemical Properties

    IV. Biological Properties


    8. Macroglobulins and High Molecular Weight Antibodies

    I. Introduction

    II. 19 S Components of Normal Serum

    III. Physical and Chemical Properties of Normal and Pathological Macroglobulins

    IV. Immunological Properties

    V. 19 S Antibodies

    VI. Waldenström's Macroglobulinemia and Related Disorders

    VII. Summary


    9. Glycoproteins

    I. Introduction

    II. Nomenclature

    III. Sugar Components in the Plasma Glycoproteins

    IV. Multiplicity of the Plasma Glycoproteins

    V. Chemical Structure of Plasma Glycoproteins

    VI. Concluding Comments


    10. Metal-Binding Plasma Proteins and Cation Transport

    I. Introduction

    II. Iron

    III. Copper

    IV. Zinc

    V. Alkaline Earth Metals


    Author Index

    Subject Index

Product details

  • No. of pages: 426
  • Language: English
  • Copyright: © Academic Press 1960
  • Published: January 1, 1960
  • Imprint: Academic Press
  • eBook ISBN: 9781483258676

About the Editor

Frank W Putnam

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