The Plasma Proteins

The Plasma Proteins

Structure, Function, and Genetic Control

2nd Edition - October 28, 1975

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  • Author: Frank W Putnam
  • eBook ISBN: 9780323138086

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Description

The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume I is a systematic account of the structure, function, and genetic control of plasma proteins. Clinical relevance is introduced in terms of principles, with emphasis on human proteins. Animal proteins are also used as examples in some cases. Comprised of nine chapters, this volume begins with a historical background on plasma proteins, along with their nomenclature, characterization, and genetic markers. The primary structure and three-dimensional conformation of plasma proteins are also considered. The discussion then turns to the chemical, physical, and biological properties of various plasma proteins such as serum albumin, lipoproteins, and immunoglobulins. Subsequent chapters deal with protease inhibitors in plasma; purification, physical properties, chemical composition, and molecular structure of transferrin; biosynthesis and metabolism of serum lipoproteins; and physical, chemical, and functional properties of the proteins of the complement system. The final chapter is devoted to ?2-microglobulin, with particular reference to its purification and physical properties; chemical composition and structure; physiological function, biosynthesis, and catabolism; and presence and function in cell membranes. This monograph will be of interest to molecular biologists and biochemists.

Table of Contents


  • List of Contributors

    Preface

    Contents of Other Volumes

    1 Perspectives-Past, Present, and Future

    I. Introduction

    II. Historical

    III. Characterization of the Plasma Proteins

    IV. The Scroll of the Plasma Proteins

    V. Genetic Markers in Plasma Proteins

    VI. Primary Structure and Three-Dimensional Conformation of Plasma Proteins

    VII. Conclusion

    References

    2 Alpha, Beta, Gamma, Omega-The Roster of the Plasma Proteins

    I. Introduction

    II. Serum Albumin

    III. Thyroxine-Binding Proteins

    IV. α- and β-Glycoproteins in Search of a Function

    V. α1-Globulins

    VI. α2-Globulins

    VII. β-Globulins

    VIII. Minor Low Molecular Weight Proteins with y or Basic Mobility and Unknown Function

    IX. Lipoproteins

    X. The Complement System

    XI. Coagulation Proteins

    XII. Immunoglobulins

    References

    3 Serum Albumin

    I. Introduction

    II. Purification and Properties

    III. Metabolism, Physiological Functions, and Alterations in Disease

    IV. Genetic Aspects and Phylogeny

    References

    4 α1-Acid Glycoprotein

    I. Introduction

    II. Isolation and Purification

    III. Crystallization

    IV. Chemical Properties

    V. Physicochemical Properties

    VI. Immunochemical Properties

    VII. Studies on the Structure of the Carbohydrate Moiety

    VIII. Polymorphism

    IX. The Carbohydrate-Protein Linkage

    X. The Amino Acid Sequence

    XI. The Amino Acid Substitutions

    XII. Homology with Other Plasma Proteins

    XIII. Secondary Structure

    XIV. Genetically Determined Protein Variants

    XV. Metabolism

    XVI. Speculations Pertaining to the Biological Role

    References

    5 Protease Inhibitors in Plasma

    I. Introduction

    II. α1-Antitrypsin

    III. α2-Macroglobulins

    IV. Other Protease Inhibitors of Plasma

    V. Comparative Biochemistry

    References

    6 Transferrin

    I. Introduction

    II. Purification and Physical Properties

    III. Chemical Composition and Molecular Structure

    IV. Genetic Variation and Population Distribution

    V. Physiological Function, Biosynthesis, and Variations in Disease

    VI. Phylogenetic Distribution

    References

    7 Serum Lipoproteins

    I. Introduction

    II. Intact Lipoproteins

    III. Lipoprotein Apoproteins

    IV. Human Disorders Associated with Serum Lipoprotein Abnormalities

    V. Genetic Polymorphism

    VI. Serum Lipoproteins in Species Other than Man

    VII. Biosynthesis and Metabolism of Serum Lipoproteins

    VIII. Physiological Function and Evolutionary Advantages

    IX. Perspectives

    References

    8 The Complement System

    I. Introduction

    II. Nomenclature

    III. General Molecular Dynamics

    IV. The Classical Pathway

    V. The Proteins and Reaction Products of the Classical Pathway

    VI. The Alternative Pathway

    VII. The Proteins and Reaction Products of the Alternative Pathway

    VIII. Regulators of the Complement System

    IX. Conclusion

    References

    9 β2-Microglobulin

    I. Introduction

    II. Purification and Physical Properties

    III. Chemical Composition and Structure

    IV. Physiological Function, Biosynthesis, and Catabolism

    V. Presence and Function in Cell Membranes

    VI. Conclusions

    References

    Subject Index

Product details

  • No. of pages: 497
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: October 28, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9780323138086

About the Author

Frank W Putnam

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