The Plasma Proteins V5

The Plasma Proteins V5

Structure, Function, and Genetic Control

2nd Edition - February 11, 1987

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  • Editor: Frank Putnam
  • eBook ISBN: 9780323161749

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The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume V explores the contribution of molecular biology and gene cloning approaches to the advancement of plasma protein structure, function, and genomic organization studies. This volume is composed of five chapters and begins with a discussion on the DNA sequences and chromosomal location of plasma protein genes, specifically the cloning and sequencing of immunoglobulin genes. These topics are followed by a discussion on the advances in relation to discovered genetic variants present either as normal phenotypes or in dyslipoproteinemic states associated with cardiovascular disease. A chapter highlights the application of molecular biology techniques to the study of gene structure and the translational and maturation steps of every major plasma apolipoprotein. Another chapter emphasizes the unique features of protein structure and the conformational changes that characterize the assembly of macromolecular complexes in plasma and on cell surfaces. The concluding chapter provides a comprehensive review of the integration of molecular biology, physiology, and pathology of plasma proteins and their response in inflammation. This book will be of great value to molecular biologists, physiologists, pathologists, and clinicians.

Table of Contents

  • Contributors


    Contents of Other Volumes

    1 DNA Sequencing and Chromosomal Locations of Human Plasma Protein Genes

    I. Introduction

    II. Plasma Proteins Mapped on Human Chromosomes

    III. Gene Organization Revealed by DNA Sequences Encoding Human Plasma Proteins

    IV. Conclusions


    2 Immunoglobulins: Structure, Function, and Genes

    I. Introduction

    II. Principles of Immunoglobulin Structure

    III. The Variable Region

    IV. Primary Structure of the Constant Regions of Immunoglobulin Polypeptide Chains

    V. Structure and Function of Oligosaccharides

    VI. Three-Dimensional Structure and Binding Sites

    VII. Cytotropic Functions of the Fc Region

    VIII. Structure and Evolution of the Immunoglobulin Supergene Family


    3 Plasma Apolipoproteins: Gene Structure, Function, and Variants

    I. Introduction

    II. ApoA-I

    III. ApoA-II

    IV. ApoA-IV

    V. ApoB

    VI. Lp(a)

    VII. ApoC-I

    VIII. ApoC-II

    IX. ApoC-III

    X. ApoE

    XI. Phylogenetic Relationships among Plasma Apolipoproteins

    XII. Apolipoprotein Variants Associated with Pathological States

    XIII. Concluding Remarks


    4 α2-Macroglobulin and Related Thiol Ester Plasma Proteins

    I. Introduction

    II. Brief Historical Perspective

    III. The Family of α2M-Related Proteins

    IV. α2M, PZP, C3, C4, and C5 as a Class of Homologous Proteins

    V. Chromosome Assignment, Genetic Variation, and Sites of Synthesis

    VI. Shape of the Macroglobulins, C3, C4, and C5

    VII. The β-Cysteinyl-γ-glutamyl Thiol Ester Structure in α2M, C3, and C4

    VIII. Conformational Change and the Nascent State

    IX. Formation and Properties of α2M-Proteinase Complexes

    X. Cell Recognition, Receptor-Mediated Endocytosis, and Cellular Effects

    XI. Conclusions and Perspectives


    5 Synthesis, Processing, and Secretion of Plasma Proteins by the Liver and Other Organs and Their Regulation

    I. Introduction: Coordinate Regulation of Plasma Protein Synthesis and Mechanism of Synthesis and Secretion

    II. Response of the Plasma Protein Synthesizing System in the Liver to Trauma and Inflammation

    III. Perinatal Development of the Plasma Protein Synthesizing System

    IV. Molecular Mechanisms of the Regulation of Plasma Protein Synthesis in the Liver

    V. Plasma Protein Synthesis in the Choroid Plexus

    VI. Human Acute-Phase Proteins and Their Physiopathological Role and Clinical Significance. Modulation of the Acute-Phase Response

    VII. Concluding Remarks


    Appendix: Sequences of Plasma Proteins

    I. Introductory Remarks

    II. Amino Acid Sequences


Product details

  • No. of pages: 432
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: February 11, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9780323161749

About the Editor

Frank Putnam

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