The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume V explores the contribution of molecular biology and gene cloning approaches to the advancement of plasma protein structure, function, and genomic organization studies.
This volume is composed of five chapters and begins with a discussion on the DNA sequences and chromosomal location of plasma protein genes, specifically the cloning and sequencing of immunoglobulin genes. These topics are followed by a discussion on the advances in relation to discovered genetic variants present either as normal phenotypes or in dyslipoproteinemic states associated with cardiovascular disease. A chapter highlights the application of molecular biology techniques to the study of gene structure and the translational and maturation steps of every major plasma apolipoprotein. Another chapter emphasizes the unique features of protein structure and the conformational changes that characterize the assembly of macromolecular complexes in plasma and on cell surfaces. The concluding chapter provides a comprehensive review of the integration of molecular biology, physiology, and pathology of plasma proteins and their response in inflammation.
This book will be of great value to molecular biologists, physiologists, pathologists, and clinicians.
Contributors Preface Contents of Other Volumes 1 DNA Sequencing and Chromosomal Locations of Human Plasma Protein Genes I. Introduction II. Plasma Proteins Mapped on Human Chromosomes III. Gene Organization Revealed by DNA Sequences Encoding Human Plasma Proteins IV. Conclusions References 2 Immunoglobulins: Structure, Function, and Genes I. Introduction II. Principles of Immunoglobulin Structure III. The Variable Region IV. Primary Structure of the Constant Regions of Immunoglobulin Polypeptide Chains V. Structure and Function of Oligosaccharides VI. Three-Dimensional Structure and Binding Sites VII. Cytotropic Functions of the Fc Region VIII. Structure and Evolution of the Immunoglobulin Supergene Family References 3 Plasma Apolipoproteins: Gene Structure, Function, and Variants I. Introduction II. ApoA-I III. ApoA-II IV. ApoA-IV V. ApoB VI. Lp(a) VII. ApoC-I VIII. ApoC-II IX. ApoC-III X. ApoE XI. Phylogenetic Relationships among Plasma Apolipoproteins XII. Apolipoprotein Variants Associated with Pathological States XIII. Concluding Remarks References 4 α2-Macroglobulin and Related Thiol Ester Plasma Proteins I. Introduction II. Brief Historical Perspective III. The Family of α2M-Related Proteins IV. α2M, PZP, C3, C4, and C5 as a Class of Homologous Proteins V. Chromosome Assignment, Genetic Variation, and Sites of Synthesis VI. Shape of the Macroglobulins, C3, C4, and C5 VII. The β-Cysteinyl-γ-glutamyl Thiol Ester Structure in α2M, C3, and C4 VIII. Conformational Change and the Nascent State IX. Formation and Properties of α2M-Proteinase Complexes X. Cell Recognition, Receptor-Mediated Endocytosis, and Cellular Effects XI. Conclusions and Perspectives References 5 Synthesis, Proc
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- © Academic Press 1987
- 11th February 1987
- Academic Press
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