The Plasma Proteins V3
Structure, Function, and Genetic Control
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The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume III is an eight-chapter treatise that describes the plasma proteins in a systematic integrated manner. This book presents first the perspectives and global outlook at plasma proteins, followed by a series of chapters on the well-characterized major proteins, with particular emphasis on immunoglobulins. Other chapters are devoted to the integrated systems of plasma proteins, especially their structure, function, and genetic control. A chapter describes the plasma protein fractionation. The remaining chapters introduce the clinical relevance of the plasma proteins. This book will be of great value to biologists, geneticists, clinicians, and researchers.
Table of Contents
List of Contributors
Preface
Contents of Other Volumes
1 Immunoglobulins I. Structure
I. Introduction
II. Chemical, Physical, and Biological Properties of Normal and Pathological Human Immunoglobulins
III. Principles of Immunoglobulin Structure
IV. Primary Structure of Human Light Chains
V. Primary Structure of the Variable Region of Heavy Chains
VI. Primary Structure of the Constant Region of Human Heavy Chains
VII. Conformation and Three-Dimensional Structure
VIII. Other Proteins and Polypeptide Chains Associated with Immunoglobulins
IX. Coda
References
2 Immunoglobulins II. Antibody Specificity and Genetic Control
I. Introduction
II. Immunoglobulin Structure and Antibody Specificity
III. Mutations, Deletions, Duplications, Recombinations, and Permutations of Immunoglobulin Structure
IV. Biological Properties of the C Region of Immunoglobulins
V. Molecular Aspects of Biosynthesis and Assembly of Immunoglobulins
References
Note Added in Proof
3 Immunoglobulins III. Comparative Biochemistry and Evolution
I. Introduction
II. Nomenclature and Criteria for Classification of Animal Immunoglobulins
III. Comparative Biochemistry of Animal Immunoglobulins
IV. Structure and Evolution of Light Chains
V. Structure and Evolution of Animal Heavy Chains
VI. Evolution of the Immunoglobulin Domain
References
4 Antibodies with Molecular Uniformity
I. Introduction
II. Evidence for Restricted Heterogeneity
III. Factors Controlling the Occurrence of Antibodies with Uniform Properties
IV. Sources of Antibodies with Restricted Heterogeneity
V. Amino Acid Sequence of Light and Heavy Chains from Homogeneous Antibodies
VI. Use of Homogeneous Antibodies to Study the Inheritance of Idiotypy
VII. Conclusions and Summary
References
5 The Group-Specific Component (Gc) System
I. Introduction
II. Detection, Purification, and Physical Properties
III. Chemical Composition and Subunit Structure
IV. Genetic Variation and Geographic Distribution
V. Function, Biosynthesis, Metabolism, and Phylogenetic Aspects
VI. Coda
References
6 Circulating Hormones
I. Introduction
II. Hormones of Pancreatic Origin
III. Pituitary Hormones
IV. Nonpituitary Polypeptide Hormones
V. Nonpolypeptide Hormones
References
7 Blood Coagulation Proteins
I. General Introduction
II. Isolation and Characterization of the Various Coagulation Factors
III. Hereditary Nature of the Clotting Disorders
IV. Molecular Mechanisms of Blood Coagulation
V. Regulation of Coagulation
References
8 Plasma Protein Fractionation
I. Introduction
II. Principles of Protein Separation
III. Well-Characterized Plasma Proteins
IV. Distribution of Proteins in the Fractions of the Alcohol and Rivanol-Ammonium Sulfate Procedures
V. Purification Methods for Individual Plasma Proteins
References
Subject Index
Product details
- No. of pages: 630
- Language: English
- Copyright: © Academic Press 1977
- Published: December 28, 1977
- Imprint: Academic Press
- eBook ISBN: 9780323161466