The Plasma Proteins V3

The Plasma Proteins V3

Structure, Function, and Genetic Control

2nd Edition - December 28, 1977

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  • Editor: Frank Putnam
  • eBook ISBN: 9780323161466

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The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume III is an eight-chapter treatise that describes the plasma proteins in a systematic integrated manner. This book presents first the perspectives and global outlook at plasma proteins, followed by a series of chapters on the well-characterized major proteins, with particular emphasis on immunoglobulins. Other chapters are devoted to the integrated systems of plasma proteins, especially their structure, function, and genetic control. A chapter describes the plasma protein fractionation. The remaining chapters introduce the clinical relevance of the plasma proteins. This book will be of great value to biologists, geneticists, clinicians, and researchers.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    1 Immunoglobulins I. Structure

    I. Introduction

    II. Chemical, Physical, and Biological Properties of Normal and Pathological Human Immunoglobulins

    III. Principles of Immunoglobulin Structure

    IV. Primary Structure of Human Light Chains

    V. Primary Structure of the Variable Region of Heavy Chains

    VI. Primary Structure of the Constant Region of Human Heavy Chains

    VII. Conformation and Three-Dimensional Structure

    VIII. Other Proteins and Polypeptide Chains Associated with Immunoglobulins

    IX. Coda


    2 Immunoglobulins II. Antibody Specificity and Genetic Control

    I. Introduction

    II. Immunoglobulin Structure and Antibody Specificity

    III. Mutations, Deletions, Duplications, Recombinations, and Permutations of Immunoglobulin Structure

    IV. Biological Properties of the C Region of Immunoglobulins

    V. Molecular Aspects of Biosynthesis and Assembly of Immunoglobulins


    Note Added in Proof

    3 Immunoglobulins III. Comparative Biochemistry and Evolution

    I. Introduction

    II. Nomenclature and Criteria for Classification of Animal Immunoglobulins

    III. Comparative Biochemistry of Animal Immunoglobulins

    IV. Structure and Evolution of Light Chains

    V. Structure and Evolution of Animal Heavy Chains

    VI. Evolution of the Immunoglobulin Domain


    4 Antibodies with Molecular Uniformity

    I. Introduction

    II. Evidence for Restricted Heterogeneity

    III. Factors Controlling the Occurrence of Antibodies with Uniform Properties

    IV. Sources of Antibodies with Restricted Heterogeneity

    V. Amino Acid Sequence of Light and Heavy Chains from Homogeneous Antibodies

    VI. Use of Homogeneous Antibodies to Study the Inheritance of Idiotypy

    VII. Conclusions and Summary


    5 The Group-Specific Component (Gc) System

    I. Introduction

    II. Detection, Purification, and Physical Properties

    III. Chemical Composition and Subunit Structure

    IV. Genetic Variation and Geographic Distribution

    V. Function, Biosynthesis, Metabolism, and Phylogenetic Aspects

    VI. Coda


    6 Circulating Hormones

    I. Introduction

    II. Hormones of Pancreatic Origin

    III. Pituitary Hormones

    IV. Nonpituitary Polypeptide Hormones

    V. Nonpolypeptide Hormones


    7 Blood Coagulation Proteins

    I. General Introduction

    II. Isolation and Characterization of the Various Coagulation Factors

    III. Hereditary Nature of the Clotting Disorders

    IV. Molecular Mechanisms of Blood Coagulation

    V. Regulation of Coagulation


    8 Plasma Protein Fractionation

    I. Introduction

    II. Principles of Protein Separation

    III. Well-Characterized Plasma Proteins

    IV. Distribution of Proteins in the Fractions of the Alcohol and Rivanol-Ammonium Sulfate Procedures

    V. Purification Methods for Individual Plasma Proteins


    Subject Index

Product details

  • No. of pages: 630
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: December 28, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323161466

About the Editor

Frank Putnam

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