The Physiology and Pharmacology of the Microcirculation

1st Edition - January 28, 1984
Editor: Nicholas A. Mortillaro
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 6 2 0 8 - 6

The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and… Read more

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The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and Pharmacology of the Microcirculation presented some general aspects of microcirculatory function and then concentrated on the microcirculation of a specific organ system, namely, brain, eye, heart, and kidneys. This second and final volume continues the presentation of microcirculatory function of specific organ systems. The book begins with a chapter on the microcirculation of the lungs, with a description of its microcirculatory features and current methods of study. This is followed by separate chapters on the microcirculation of the splanchnic organs. These include the stomach, emphasizing hemodynamics, tissue oxygenation, and control of blood flow; the small and large intestine. Subsequent chapters deal with the microcirculatory responses of both the liver and spleen to different physiological and pharmacological challenges; the microcirculation of the skin, with emphasis on human microcirculation; normal and abnormal microcirculatory dynamics in skeletal muscle; microcirculation of bone; and microcirculation of the salivary glands and exocrine pancreas. The final chapter presents a selective review of pathological events involving the microcirculation, with the emphasis directed toward human diseases.

Contributors

Foreword

Preface

Contents of Volume 1

1. Microcirculation of the Lungs

I. Introduction

II. Anatomic Features of the Pulmonary Circulation

III. Physiologic and Functional Aspects

IV. Some Current Problems and Directions for Future Studies

References

2. Microcirculation of the Stomach

I. Anatomy of a Gastric Circulation

II. Methods for Measuring Gastric Hemodynamics and Oxygenation

III. Control of Gastric Blood Flow

IV. Pathophysiology

References

3. Microcirculation of the Small Intestine

I. Introduction

II. Anatomic Overview

III. Blood Flow and Flow Distribution

IV. Regulation of Intestinal Blood Flow

V. Fluid Exchange

VI. Effects of Pharmacologic Agents and Physiologic Manipulations

VII. Concluding Remarks

References

4. Microcirculation of the Large Intestine

I. Introduction

II. Anatomic Considerations

III. Blood Flow

IV. Capillary Fluid and Solute Exchange

V. Conclusions

References

5. Microcirculation of the Liver and Spleen

I. Introduction and Anatomic Considerations

II. Regulation of Liver Blood Flow

III. Regulation of Liver Volume

IV. Regulation of Hepatic Sinusoid Diameter

V. Regulation of Hepatic Oxygen Uptake

VI. Hepatic Fluid Exchange

VII. Regulation of Splenic Blood Flow

VIII. Regulation of Splenic Oxygen Uptake

IX. Regulation of Splenic Fluid Exchange

X. The Spleen as a Store of Red Blood Cells

XI. Summary and Conclusions

References

6. Microcirculation of the Skin

I. Introduction

II. Anatomy of Skin Microcirculation

III. Skin Blood Flow

IV. Techniques for Studying Skin Microcirculation in Humans

V. Changes in Skin Microcirculation in Different Pathologic Conditions

VI. Study of Human Skin Microcirculation in the Future

References

7. Microcirculation of Skeletal Muscle

I. Introduction

II. Architecture

III. Hemodynamics

IV. Microvascular Smooth Muscle

V. Local Metabolic Regulation of Muscle Perfusion and Oxygenation

VI. Intrinsic Myogenic Control of the Microvasculature

VIL Transmicrovascular Exchanges of Water and Hydrophilic Solutes

VIII. Nervous Influences on Muscle Microvasculature

IX. Hormonal Influences on Muscle Microvasculature

X. Pathobiology of the Muscle Microcirculation

XI. Epilogue

References

8. Microcirculation of Bone

I. Morphology of the Vascular System in Bone

II. Blood Flow

III. Physiology of Turnover of Bone (Repair)

IV. Molecular and Ionic Exchange in Cortical Bone

V. Pharmacokinetics of Antimicrobial Agents in Normal and Osteomyelitic Bone

VI. Action of Hormones on Bone

References

9. Microcirculation of the Exocrine Glands

I. Introduction

II. The Salivary Gland

III. The Pancreas

References

10. Pathophysiology Involving the Microcirculation

I. Introduction

II. Functional Anatomy of the Microvascular Endothelium

III. Small Blood Vessel Responses to Injury

References

Index