The Physiology and Pharmacology of the Microcirculation

The Physiology and Pharmacology of the Microcirculation

1st Edition - January 28, 1983

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  • Editor: Nicholas Mortillaro
  • eBook ISBN: 9780323147477

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The Physiology and Pharmacology of the Microcirculation, Volume 1 discusses the biochemistry, metabolism, pharmacology, and physiology of the general microcirculation. This volume is organized into nine chapters that explore the microcirculation in several organ systems, such as brain, eye, heart, and kidney. The introductory chapters treat the biochemistry of isolated elements of the microvasculature, with special emphasis on the central nervous system. These chapters also explore the microvascular element and the vascular smooth muscle, focusing on their ultrastructural characteristics, innervation, and contraction-relaxation, and the effects of both endogenous and pharmacological vasoactive substances on vascular smooth muscle. The subsequent chapters deal with the exchange mode of the microcirculation; the mechanisms involved in the regulation of transcapillary fluid exchange; and the permeability of capillaries to small and large molecules in a variety of tissues. A discussion on the control mechanisms modulating microcirculatory dynamics is also included. The remaining four chapters are organized to deal with the microcirculation process in selected organs.

Table of Contents

  • Contributors



    Contents of Volume 2

    1. Biochemical Mechanisms of the Microvasculature

    I. Introduction

    II. Techniques for Isolation of Microvessels

    III. Monoamine Mechanisms

    IV. Other Receptor Mechanisms and Associated Biochemical Events

    V. Transport Processes and Related Carrier Enzymes

    VI. Other Enzyme Systems

    VII. Conclusions


    2. Regulation of Vascular Smooth Muscle of the Microcirculation

    I. Introduction

    II. Vascular Smooth Muscle in the Microcirculation

    III. Humoral Factors Affecting Vascular Smooth Muscle

    IV. Directions for Future Research


    3. Fluid Exchange in the Microcirculation

    I. Introduction

    II. Starling Forces Defined

    III. Interactive Relationship among the Starling Forces

    IV. Drug Effects

    V. Future Endeavors

    VI. References

    4. Permeability Characteristics of the Microcirculation

    I. Introduction

    II. Methods for Studying Vascular Permeability

    III. Applications of Vascular Permeability Data to Pore Theory

    IV. Ultrastructural Basis for Capillary Permeability


    5. Microcirculatory Control Systems

    I. Introduction

    II. Local Microcirculatory Control Systems

    III. Remote Control of the Microcirculation

    IV. Conclusions


    6. Microcirculation of the Brain

    I. Introduction

    II. Anatomic Considerations

    III. Methods of Studying the Cerebral Circulation

    IV. Regulation of Cerebral Blood Flow

    V. Regulation of Cerebral Blood Flow in the Fetus and Neonate

    VI. Future Directions


    7. Microcirculation of the Eye

    I. Introduction

    II. Anatomic Considerations

    III. Methods Used in Studies of Ocular Blood Flow

    IV. Normal Blood Flow

    V. Physiologic Regulation of Ocular Blood Flow

    VI. Pharmacologic Regulation of Ocular Blood Flow

    VII. Fluid Exchange within the Eye

    VIII. Exchange of Metabolites between Blood and Retina

    IX. Concluding Remarks


    8. Microcirculation of the Heart

    I. Functional Anatomy

    II. The Coronary Vessel Wall

    III. Microcirculatory Exchange

    IV. Determinants of Coronary Blood Flow

    V. Coronary Circulation during Ischemia


    9. Microcirculation of the Kidneys

    I. Introduction

    II. Structural Aspects of the Renal Microcirculation

    III. Fluid and Solute Exchange across the Cortical Capillaries

    IV. Distribution of Blood Flow within the Kidney

    V. Physiologic Control of the Renal Microcirculation

    VI. Concluding Comments



Product details

  • No. of pages: 514
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323147477

About the Editor

Nicholas Mortillaro

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