The Physiological Basis of Memory

1st Edition - August 28, 1983
Editor: J. Anthony Deutsch
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 9 9 6 - 9

The Physiological Basis of Memory, Second Edition reviews many areas of research that shed light on the physiological basis of memory, from mnemonic function and memory… Read more

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The Physiological Basis of Memory, Second Edition reviews many areas of research that shed light on the physiological basis of memory, from mnemonic function and memory facilitation to synaptic transmission. The book also considers neuropsychology involving animal subjects, learning produced by direct brain stimulation, and the basis of associative learning at the cellular level. This edition is organized into 10 chapters and begins with an overview of the link between protein synthesis and memory, paying attention to studies devoted to chemical changes associated with learning; the effect of inhibitors of RNA and protein synthesis on learning; the molecular code of memory; and the role of proteins in learning. The reader is methodically introduced to the enhancement of memory consolidation; the use of the cellular-connection approach to investigate both non-associative and associative learning; and the effect of depression on memory storage. The following chapters discuss the impact of brain lesions on animal memory; the neurology of memory and amnesia in human and nonhuman primates; the function of the neural substrate for self-stimulation of the medial forebrain bundle; and the effects of electroconvulsive shock on memory. A chapter on the role of catecholamines in memory processing concludes the book. This book should be useful to researchers and students interested in the physiology of memory.

Contributors

Preface to the First Edition

Preface to the Second Edition

Chapter 1. Protein Synthesis and Memory

I. Introduction

II. Chemical Changes Associated with Learning

III. Effect of Inhibitors of RNA and Protein Synthesis on Learning

IV. The Search for a Molecular Code of Memory

V. Modern Conceptions of the Role of Proteins in Learning

VI. Conclusions

References

Chapter 2. Facilitation of Memory Consolidation

I. Introduction

II. Pretraining versus Post Training Treatments

III. Time Dependency

IV. Memory Modulation

V. Attenuation of Experimentally Induced Amnesia

VI. On the Nature of Specificity

VII. Peripheral Mechanisms

VIII. Conclusions

References

Chapter 3. Cellular Neurophysiological Studies of Learning

I. Introduction

II. Nonassociative Learning: Habituation and Sensitization

III. Associative Learning: Introduction

IV. Vertebrate Studies of Associative Learning

V. Invertebrate Studies of Associative Learning

VI. Conclusions

References

Chapter 4. Spreading Depression: A Behavioral Analysis

I. Introduction

II. The Neural Properties of Spreading Depression

III. Methodological Requirements for Using Spreading Depression in Behavioral Research

IV. The Behavioral Effects of Spreading Depression

V. Reevaluating the Behavioral Effects of Spreading Depression

VI. Conclusion

References

Chapter 5. Brain Lesions and Memory in Animals: A Reappraisal

I. Introduction

II. The Nature of the Medial Temporal Amnesia in Humans

III. Production of Temporal Lobe Amnesia in Experimental Animals

IV. The Frontal Lobes and Memory

V. The Effects of Frontal Lesions in Humans

VI. A Final Synthesis

VII. Summary

References

Chapter 6. The Neurology of Memory: The Case for Correspondence between the Findings for Human and Nonhuman Primate

I. Introduction

II. Description and Etiology of Amnesia

III. Two Forms of Amnesia

IV. What Has Human Diencephalic and Bitemporal Amnesia Taught Us about the Nature of the Impairment?

V. What Has Human Diencephalic and Bitemporal Amnesia Taught Us about the Regions That Are Affected?

VI. Studies of Monkeys with Hippocampal Lesions

VII. The Brain Regions Critical to Amnesia: Two Hypotheses

VIII. The Behavioral Tasks Used to Study Memory in Monkeys: Some Are Sensitive to Human Amnesia, but Others Are Not

IX. Summary

References

Chapter 7. Self-Stimulation

I. Introduction

II. The Normal Function of the Neural Substrate for Self-Stimulation of the MFB

III. Identifying the Substrate

IV. Conclusions

References

Chapter 8. Electroconvulsive Shock and Memory

I. Introduction

II. Amnesic Effects of ECS

III. The Consolidation Process

IV. Concluding Remarks

References

Chapter 9. The Cholinergic Synapse and the Site of Memory

I. Introduction

II. Experimental Investigations

III. Conclusions

References

Chapter 10. The Role of Catecholamines in Memory Processing

I. Introduction

II. Methodological Considerations

III. Catecholamines and Memory Processing

References

Index