The Physiological Basis of Memory

The Physiological Basis of Memory

1st Edition - August 28, 1983

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  • Editor: J. Anthony Deutsch
  • eBook ISBN: 9780323149969

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The Physiological Basis of Memory, Second Edition reviews many areas of research that shed light on the physiological basis of memory, from mnemonic function and memory facilitation to synaptic transmission. The book also considers neuropsychology involving animal subjects, learning produced by direct brain stimulation, and the basis of associative learning at the cellular level. This edition is organized into 10 chapters and begins with an overview of the link between protein synthesis and memory, paying attention to studies devoted to chemical changes associated with learning; the effect of inhibitors of RNA and protein synthesis on learning; the molecular code of memory; and the role of proteins in learning. The reader is methodically introduced to the enhancement of memory consolidation; the use of the cellular-connection approach to investigate both non-associative and associative learning; and the effect of depression on memory storage. The following chapters discuss the impact of brain lesions on animal memory; the neurology of memory and amnesia in human and nonhuman primates; the function of the neural substrate for self-stimulation of the medial forebrain bundle; and the effects of electroconvulsive shock on memory. A chapter on the role of catecholamines in memory processing concludes the book. This book should be useful to researchers and students interested in the physiology of memory.

Table of Contents

  • Contributors

    Preface to the First Edition

    Preface to the Second Edition

    Chapter 1. Protein Synthesis and Memory

    I. Introduction

    II. Chemical Changes Associated with Learning

    III. Effect of Inhibitors of RNA and Protein Synthesis on Learning

    IV. The Search for a Molecular Code of Memory

    V. Modern Conceptions of the Role of Proteins in Learning

    VI. Conclusions


    Chapter 2. Facilitation of Memory Consolidation

    I. Introduction

    II. Pretraining versus Post Training Treatments

    III. Time Dependency

    IV. Memory Modulation

    V. Attenuation of Experimentally Induced Amnesia

    VI. On the Nature of Specificity

    VII. Peripheral Mechanisms

    VIII. Conclusions


    Chapter 3. Cellular Neurophysiological Studies of Learning

    I. Introduction

    II. Nonassociative Learning: Habituation and Sensitization

    III. Associative Learning: Introduction

    IV. Vertebrate Studies of Associative Learning

    V. Invertebrate Studies of Associative Learning

    VI. Conclusions


    Chapter 4. Spreading Depression: A Behavioral Analysis

    I. Introduction

    II. The Neural Properties of Spreading Depression

    III. Methodological Requirements for Using Spreading Depression in Behavioral Research

    IV. The Behavioral Effects of Spreading Depression

    V. Reevaluating the Behavioral Effects of Spreading Depression

    VI. Conclusion


    Chapter 5. Brain Lesions and Memory in Animals: A Reappraisal

    I. Introduction

    II. The Nature of the Medial Temporal Amnesia in Humans

    III. Production of Temporal Lobe Amnesia in Experimental Animals

    IV. The Frontal Lobes and Memory

    V. The Effects of Frontal Lesions in Humans

    VI. A Final Synthesis

    VII. Summary


    Chapter 6. The Neurology of Memory: The Case for Correspondence between the Findings for Human and Nonhuman Primate

    I. Introduction

    II. Description and Etiology of Amnesia

    III. Two Forms of Amnesia

    IV. What Has Human Diencephalic and Bitemporal Amnesia Taught Us about the Nature of the Impairment?

    V. What Has Human Diencephalic and Bitemporal Amnesia Taught Us about the Regions That Are Affected?

    VI. Studies of Monkeys with Hippocampal Lesions

    VII. The Brain Regions Critical to Amnesia: Two Hypotheses

    VIII. The Behavioral Tasks Used to Study Memory in Monkeys: Some Are Sensitive to Human Amnesia, but Others Are Not

    IX. Summary


    Chapter 7. Self-Stimulation

    I. Introduction

    II. The Normal Function of the Neural Substrate for Self-Stimulation of the MFB

    III. Identifying the Substrate

    IV. Conclusions


    Chapter 8. Electroconvulsive Shock and Memory

    I. Introduction

    II. Amnesic Effects of ECS

    III. The Consolidation Process

    IV. Concluding Remarks


    Chapter 9. The Cholinergic Synapse and the Site of Memory

    I. Introduction

    II. Experimental Investigations

    III. Conclusions


    Chapter 10. The Role of Catecholamines in Memory Processing

    I. Introduction

    II. Methodological Considerations

    III. Catecholamines and Memory Processing



Product details

  • No. of pages: 448
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: August 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323149969

About the Editor

J. Anthony Deutsch

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