The Pharmacology of Neurogenesis and Neuroenhancement - 1st Edition - ISBN: 9780123736789, 9780080469188

The Pharmacology of Neurogenesis and Neuroenhancement, Volume 77

1st Edition

Serial Volume Editors: Donard Dwyer
Hardcover ISBN: 9780123736789
eBook ISBN: 9780080469188
Imprint: Academic Press
Published Date: 2nd January 2007
Page Count: 344
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Table of Contents

  • Contributors to Volume 77
  • Preface
  • Regenerating the Brain
    • Publisher Summary
    • I Introduction
    • II Neurodegenerative Diseases: Therapeutic Targets for Neurogenesis
    • III Building Brains: Evolution and Development
    • IV Endogenous and Exogenous Sources of New Neurons
    • V Endogenous Adult Neurogenesis
    • VI Injury‐Induced Neurogenesis
    • VII Neurogenesis in Stroke
    • VIII Neurogenesis in AD
    • IX Neurogenesis in HD
    • X Neurogenesis in PD
    • XI Neurogenesis in Motor Neuron Disease
    • XII Convergent and Divergent Features of Injury‐Induced Neurogenesis
    • XIII Unanswered Questions
    • Acknowledgments
  • Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis
    • Publisher Summary
    • I Introduction
    • II Evolution: From Unicellular to Humans
    • III Holistic Brain Function Starts at Development
    • IV Homeostasis of Brain
    • V Clinical Implications of Loss of Homeostasis
  • Therapeutic Approaches to Promoting Axonal Regeneration in the Adult Mammalian Spinal Cord
    • Publisher Summary
    • I Introduction
    • II Growth‐Inhibiting Properties of the Glial Scar
    • III Inhibition of Axonal Regeneration by CNS Myelin
    • IV Cell‐Based Strategies to Promote Regeneration
    • V Future Directions
  • Evidence for Neuroprotective Effects of Antipsychotic Drugs: Implications for the Pathophysiology and Treatment of Schizophrenia
    • Publisher Summary
    • I Introduction
    • II Altered Levels of NTs and Their Receptors by Antipsychotic Drugs
    • III The Regulation of Neurogenesis by Antipsychotic Drugs
    • IV Neuroprotective Effects of Antipsychotic Drugs
    • Acknowledgments
  • Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder
    • Publisher Summary
    • I Introduction
    • II Clinical Evidence for a Role of Neuroplasticity in BPD
    • III Preclinical In Vivo and In Vitro Studies
    • IV Conclusions
  • Neuroreplacement, Growth Factor, and Small Molecule Neurotrophic Approaches for Treating Parkinson’s Disease
    • Publisher Summary
    • I Introduction
    • II Etiology of PD
    • III Current Treatment for PD
    • IV Rodent Models of PD Used to Evaluate Putative Neuroprotective Therapies
    • V Approaches to Brain Repair in PD
    • VI Summary and Conclusions
    • Acknowledgments
  • Using Caenorhabditis elegans Models of Neurodegenerative Disease to Identify Neuroprotective Strategies
    • Publisher Summary
    • I Introduction
    • II C. elegans Models of Neurodegenerative Disorders
    • III Identifying Candidate Modifier Genes of Neurodegeneration
    • IV Molecular Inhibitors of Neurodegeneration
    • V Neuroprotective Strategies
    • VI Utility of HTS for Drugs in Worms
    • VII Conclusions
  • Neuroprotection and Enhancement of Neurite Outgrowth With Small Molecular Weight Compounds From Screens of Chemical Libraries
    • Publisher Summary
    • I Introduction
    • II Brain Deficit Disorders: The Challenges
    • III Treatment Objectives
    • IV Application to Neurodevelopmental Disorders: Schizophrenia
    • V Screening and Identification of Novel Compounds for Drug Discovery
    • VI Neurodevelopmental Disorders and Neurodegenerative Diseases
    • VII Future Directions
    • Acknowledgments
  • Index
  • Contents of Recent Volumes

Description

  • Contributors to Volume 77
  • Preface
  • Regenerating the Brain
    • Publisher Summary
    • I Introduction
    • II Neurodegenerative Diseases: Therapeutic Targets for Neurogenesis
    • III Building Brains: Evolution and Development
    • IV Endogenous and Exogenous Sources of New Neurons
    • V Endogenous Adult Neurogenesis
    • VI Injury‐Induced Neurogenesis
    • VII Neurogenesis in Stroke
    • VIII Neurogenesis in AD
    • IX Neurogenesis in HD
    • X Neurogenesis in PD
    • XI Neurogenesis in Motor Neuron Disease
    • XII Convergent and Divergent Features of Injury‐Induced Neurogenesis
    • XIII Unanswered Questions
    • Acknowledgments
  • Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis
    • Publisher Summary
    • I Introduction
    • II Evolution: From Unicellular to Humans
    • III Holistic Brain Function Starts at Development
    • IV Homeostasis of Brain
    • V Clinical Implications of Loss of Homeostasis
  • Therapeutic Approaches to Promoting Axonal Regeneration in the Adult Mammalian Spinal Cord
    • Publisher Summary
    • I Introduction
    • II Growth‐Inhibiting Properties of the Glial Scar
    • III Inhibition of Axonal Regeneration by CNS Myelin
    • IV Cell‐Based Strategies to Promote Regeneration
    • V Future Directions
  • Evidence for Neuroprotective Effects of Antipsychotic Drugs: Implications for the Pathophysiology and Treatment of Schizophrenia
    • Publisher Summary
    • I Introduction
    • II Altered Levels of NTs and Their Receptors by Antipsychotic Drugs
    • III The Regulation of Neurogenesis by Antipsychotic Drugs
    • IV Neuroprotective Effects of Antipsychotic Drugs
    • Acknowledgments
  • Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder
    • Publisher Summary
    • I Introduction
    • II Clinical Evidence for a Role of Neuroplasticity in BPD
    • III Preclinical In Vivo and In Vitro Studies
    • IV Conclusions
  • Neuroreplacement, Growth Factor, and Small Molecule Neurotrophic Approaches for Treating Parkinson’s Disease
    • Publisher Summary
    • I Introduction
    • II Etiology of PD
    • III Current Treatment for PD
    • IV Rodent Models of PD Used to Evaluate Putative Neuroprotective Therapies
    • V Approaches to Brain Repair in PD
    • VI Summary and Conclusions
    • Acknowledgments
  • Using Caenorhabditis elegans Models of Neurodegenerative Disease to Identify Neuroprotective Strategies
    • Publisher Summary
    • I Introduction
    • II C. elegans Models of Neurodegenerative Disorders
    • III Identifying Candidate Modifier Genes of Neurodegeneration
    • IV Molecular Inhibitors of Neurodegeneration
    • V Neuroprotective Strategies
    • VI Utility of HTS for Drugs in Worms
    • VII Conclusions
  • Neuroprotection and Enhancement of Neurite Outgrowth With Small Molecular Weight Compounds From Screens of Chemical Libraries
    • Publisher Summary
    • I Introduction
    • II Brain Deficit Disorders: The Challenges
    • III Treatment Objectives
    • IV Application to Neurodevelopmental Disorders: Schizophrenia
    • V Screening and Identification of Novel Compounds for Drug Discovery
    • VI Neurodevelopmental Disorders and Neurodegenerative Diseases
    • VII Future Directions
    • Acknowledgments
  • Index
  • Contents of Recent Volumes

Key Features

  • Provides state-of-the-art reviews spanning significant emerging fields
  • Discusses future directions and questions for future studies
  • Includes informative illustrations

Readership

Neuroscientists, neurologists and pharmacologists.


Details

No. of pages:
344
Language:
English
Copyright:
© Academic Press 2007
Published:
Imprint:
Academic Press
eBook ISBN:
9780080469188
Hardcover ISBN:
9780123736789

About the Serial Volume Editors

Donard Dwyer Serial Volume Editor