The Pharmacology of Neurogenesis and Neuroenhancement

The Pharmacology of Neurogenesis and Neuroenhancement

1st Edition - January 2, 2007

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  • Editor: Donard Dwyer
  • Hardcover ISBN: 9780123736789
  • eBook ISBN: 9780080469188

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Currently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders. Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints. This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection. A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues. This collection of reviews is a perfect way to become acquainted with these exciting new fields in the space of a single volume. Chapters are written with a general audience in mind, but with enough high-level discussion to appeal to specialists and experts as well. The authors have done an excellent job of challenging current paradigms and pushing the boundaries of exploration in keeping with the pioneering spirit that gave rise to these emerging areas of research. Consequently, this will be an indispensable resource for many years to come.

Key Features

  • Provides state-of-the-art reviews spanning significant emerging fields
  • Discusses future directions and questions for future studies
  • Includes informative illustrations


Neuroscientists, neurologists and pharmacologists.

Table of Contents

    • Contributors to Volume 77
    • Preface
    • Regenerating the Brain
      • Publisher Summary
      • I Introduction
      • II Neurodegenerative Diseases: Therapeutic Targets for Neurogenesis
      • III Building Brains: Evolution and Development
      • IV Endogenous and Exogenous Sources of New Neurons
      • V Endogenous Adult Neurogenesis
      • VI Injury‐Induced Neurogenesis
      • VII Neurogenesis in Stroke
      • VIII Neurogenesis in AD
      • IX Neurogenesis in HD
      • X Neurogenesis in PD
      • XI Neurogenesis in Motor Neuron Disease
      • XII Convergent and Divergent Features of Injury‐Induced Neurogenesis
      • XIII Unanswered Questions
      • Acknowledgments
    • Serotonin and Brain: Evolution, Neuroplasticity, and Homeostasis
      • Publisher Summary
      • I Introduction
      • II Evolution: From Unicellular to Humans
      • III Holistic Brain Function Starts at Development
      • IV Homeostasis of Brain
      • V Clinical Implications of Loss of Homeostasis
    • Therapeutic Approaches to Promoting Axonal Regeneration in the Adult Mammalian Spinal Cord
      • Publisher Summary
      • I Introduction
      • II Growth‐Inhibiting Properties of the Glial Scar
      • III Inhibition of Axonal Regeneration by CNS Myelin
      • IV Cell‐Based Strategies to Promote Regeneration
      • V Future Directions
    • Evidence for Neuroprotective Effects of Antipsychotic Drugs: Implications for the Pathophysiology and Treatment of Schizophrenia
      • Publisher Summary
      • I Introduction
      • II Altered Levels of NTs and Their Receptors by Antipsychotic Drugs
      • III The Regulation of Neurogenesis by Antipsychotic Drugs
      • IV Neuroprotective Effects of Antipsychotic Drugs
      • Acknowledgments
    • Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder
      • Publisher Summary
      • I Introduction
      • II Clinical Evidence for a Role of Neuroplasticity in BPD
      • III Preclinical In Vivo and In Vitro Studies
      • IV Conclusions
    • Neuroreplacement, Growth Factor, and Small Molecule Neurotrophic Approaches for Treating Parkinson’s Disease
      • Publisher Summary
      • I Introduction
      • II Etiology of PD
      • III Current Treatment for PD
      • IV Rodent Models of PD Used to Evaluate Putative Neuroprotective Therapies
      • V Approaches to Brain Repair in PD
      • VI Summary and Conclusions
      • Acknowledgments
    • Using Caenorhabditis elegans Models of Neurodegenerative Disease to Identify Neuroprotective Strategies
      • Publisher Summary
      • I Introduction
      • II C. elegans Models of Neurodegenerative Disorders
      • III Identifying Candidate Modifier Genes of Neurodegeneration
      • IV Molecular Inhibitors of Neurodegeneration
      • V Neuroprotective Strategies
      • VI Utility of HTS for Drugs in Worms
      • VII Conclusions
    • Neuroprotection and Enhancement of Neurite Outgrowth With Small Molecular Weight Compounds From Screens of Chemical Libraries
      • Publisher Summary
      • I Introduction
      • II Brain Deficit Disorders: The Challenges
      • III Treatment Objectives
      • IV Application to Neurodevelopmental Disorders: Schizophrenia
      • V Screening and Identification of Novel Compounds for Drug Discovery
      • VI Neurodevelopmental Disorders and Neurodegenerative Diseases
      • VII Future Directions
      • Acknowledgments
    • Index
    • Contents of Recent Volumes

Product details

  • No. of pages: 344
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: January 2, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123736789
  • eBook ISBN: 9780080469188

About the Serial Volume Editor

Donard Dwyer

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