The Peptides Analysis, Synthesis, Biology - 1st Edition - ISBN: 9780123042040, 9780323155632

The Peptides Analysis, Synthesis, Biology

1st Edition

Modern Techniques of Conformational Structural, and Configurational Analysis

Editors: Erhard Gross
eBook ISBN: 9780323155632
Imprint: Academic Press
Published Date: 28th August 1981
Page Count: 330
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The Peptides: Analysis, Synthesis, Biology: Volume 4: Modern Techniques of Conformational, Structural, and Configurational Analysis is an open-ended treatise that provides comprehensive and critical reviews of important developments in all areas of peptide research including analysis, synthesis, and biology. X-ray structure studies, amino acid analysis, and chiroptical analysis of configuration are discussed, along with solid-phase sequencing and ultramicroanalysis with the aid of fluorescence. This volume is comprised of six chapters and begins with an account of crystal structure analysis on molecules containing 2-12 peptide units, focusing on the variety of intramolecular hydrogen bonds, cis peptide units, and multiple conformation. Conformational changes upon complexation with metal ions are considered, together with the inclusion of solvents as integral parts of a molecular structure. The following chapters explore the conformations of insulin, glucagon, pancreatic polypeptide and related molecules, as well as the molecular biology of these hormones based on crystal structures; the usefulness of chiroptical techniques for determining the absolute configuration of amino acids and small peptides; and ultramicroanalysis of peptides and proteins by high performance liquid chromatography and fluorescence detection. The final chapter looks at the status and future potential of solid-phase sequencing. This book is intended as a reference for specialists, a guide for the novice, and a forum for investigators concerned with research on peptides and proteins.

Table of Contents

List of Contributors Preface Nomenclature and Abbreviations Contents of Previous Volumes Chapter 1. X-Ray Analysis: Conformation of Peptides in the Crystalline State I. Introductory Remarks II. Cyclic Dipeptides III. Peptides Containing Tri-, Tetra-, and Pentapeptide Rings IV. Hexapeptide and Heptapeptide Rings V. Cyclic Octapeptides to Pentadecapeptides VI. Linear Peptides VII. Geometry of the Peptide Unit VIII. Intramolecular Hydrogen Bonds IX. Summary References Chapter 2. Crystal Structure Analysis of the Larger Peptide Hormones I. Introduction II. Insulin and Proinsulin III. Hormones Homologous to Insulin IV. Glucagon V. Pancreatic Polypeptide VI. Placental and Pituitary Hormones VII. Conclusion and Outlook References Chapter 3. Determination of the Absolute Configuration of α-Amino Acids and Small Peptides by Chiroptical Means I. Introduction II. Definitions: Optical Rotatory Dispersion and Circular Dichroism III. Chiroptical Properties of Amino Acids IV. Chiroptical Properties of Metal Complexes and Chromophoric Derivatives of α-Amino Acids V. Chiroptical Properties of Oligopeptides VI. Chiroptical Properties of Metal Complexes and Chromophoric Derivatives of Di- and Oligopeptides VII. Solvent, Salt, and Temperature Effects VIII. Instrumentation IX. Calibration and Standards X. Conclusion and Outlook References Chapter 4. Ultramicroanalysis of Peptides and Proteins by High-Performance Liquid Chromatography and Fluorescence Detection I. Introduction II. Detection III. High-Performance Liquid Chromatography IV. Applications V. Conclusion References Chapter 5. Amino Acid Analysis of Peptides I. Introduction II. Historical III. Experimental IV. Concluding Remarks References Chapter 6. Solid-Phase Sequencing of Peptides


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© Academic Press 1981
Academic Press
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About the Editor

Erhard Gross

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