The Pathophysiology and Pharmacotherapy of Myocardial Infarction

The Pathophysiology and Pharmacotherapy of Myocardial Infarction

1st Edition - January 28, 1986

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  • Editors: Nabil El-Sherif, C. V. Ramana Reddy
  • eBook ISBN: 9781483277141

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The Pathophysiology and Pharmacotherapy of Myocardial Infarction deals with the advances in the pathophysiology and pharmacotherapy of acute myocardial infarction and related complications. This book covers two major consequences—cardiac muscle dysfunction and cardiac electrical dysfunction. This text begins by reviewing the controversy surrounding the pathogenetic mechanisms of atheroma formation and its potential reversibility, including the status of coronary risk factors and benefits of primary prevention. The pathophysiologic mechanisms of pump failure and the current approach to its management are then deliberated, followed by a discussion on the rational use of vasodilators in post-infarction heart failure and pharmacotherapy of cardiogenic shock. The rationale for the interest in the role of coronary vasospasm and thrombolytic therapy for acute myocardial infarction is also covered. This publication concludes by reviewing the approaches for the management of post-infarction ventricular tachyarrhythmias and concept of secondary prevention of sudden cardiac death. This compilation is valuable to medical students, primary care physicians, and cardiovascular specialists.

Table of Contents

  • Contributors


    1. Pathogenesis of Coronary Atherosclerosis: Prevention of Atherogenesis

    I. The Atherosclerotic Lesion

    II. Pathogenesis of Atherosclerosis

    III. Risk Factors in Atherogenesis

    IV. Clinical Trials

    V. Regression of Atheroma in Humans

    VI. Regression of Atheroma in Experimental Animals


    2. Hemodynamic Consequences of Myocardial Infarction and the Role of Vasodilators in Acute and Chronic Management

    I. Introduction

    II. Hemodynamic Consequences of Heart Failure

    III. Potential Benefits of Vasodilators in Congestive Heart Failure

    IV. Classification and Mechanisms of Vasodilation

    V. Site of Action of the Vasodilators

    VI. Vasodilator Agents: Pharmacology, Hemodynamics, and Side Effects

    VII. Clinical Applications

    VIII. Summary


    3. Pump Failure: Role of Vasopressor Agents

    I. Introduction

    II. Pathophysiology

    III. Role of Vasopressor Agents in the Treatment of Pump Failure

    IV. Future Directions


    4. Coronary Artery Spasm and Pharmacology of Coronary Vasodilators

    I. Introduction

    II. Coronary Artery Spasm: Evolution of Current Concepts

    III. Coronary Artery Spasm and Myocardial Infarction

    IV. Pathophysiological Mechanisms

    V. Pharmacology of Coronary Vasodilators

    VI. Summary


    5. Physiologic Basis and Results of Thrombolytic Therapy in Acute Myocardial Infarction

    I. Introduction

    II. Physiology of Thrombus Formation and Fibrinolytic Enzyme System

    III. Early Trials of Long-Duration, Late Intravenous Thrombolytic Therapy in Acute Myocardial Infarction

    IV. Intracoronary Streptokinase

    V. Intravenous Streptokinase

    VI. Management of Patients after Thrombolytic Therapy

    VII. Future Directions


    6. Electrophysiology of Ventricular Arrhythmias in Myocardial Infarction

    I. Introduction

    II. Electrophysiological Mechanisms of Ventricular Arrhythmias

    III. Electrophysiological Mechanisms of Ventricular Arrhythmias in Myocardial Infarction

    IV. Conclusion


    7. The Pharmacology of Antiarrhythmic Drugs

    I. Introduction

    II. Pharmacokinetics

    III. Antiarrhythmic Drugs

    IV. Summary


    8. Mechanisms and Management of Myocardial Infarction Arrhythmias

    I. Introduction

    II. Mechanisms of Cardiac Arrhythmias

    III. Mechanisms of Arrhythmias during Infarction

    IV. Clinical Studies

    V. Pharmacology of Antiarrhythmic Drugs

    VI. Effects of Antiarrhythmic Drugs in Ischemie Tissue

    VII. Drug Therapy of Arrhythmias during Acute Myocardial Infarction

    VIII. Prophylaxis for Postinfarction Sudden Death

    IX. Conclusions


    9. Pharmacologie and Surgical Therapy of Postinfarction Ventricular Arrhythmias

    I. Introduction

    II. Ventricular Ectopy and Nonsustained Ventricular Tachycardia

    III. Ventricular Fibrillation

    IV. Ventricular Tachycardia

    V. Summary


    10. The Role of Beta Blockers in the Prevention of Sudden Cardiac Death in the Postinfarction Patient

    I. Introduction

    II. Methods

    III. Results

    IV. Discussion

    V. Summary



Product details

  • No. of pages: 402
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: January 28, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9781483277141

About the Editors

Nabil El-Sherif

C. V. Ramana Reddy

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