The Pathophysiology and Pharmacotherapy of Myocardial Infarction - 1st Edition - ISBN: 9780122380457, 9781483277141

The Pathophysiology and Pharmacotherapy of Myocardial Infarction

1st Edition

Editors: Nabil El-Sherif C. V. Ramana Reddy
eBook ISBN: 9781483277141
Imprint: Academic Press
Published Date: 28th January 1986
Page Count: 402
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The Pathophysiology and Pharmacotherapy of Myocardial Infarction deals with the advances in the pathophysiology and pharmacotherapy of acute myocardial infarction and related complications.

This book covers two major consequences—cardiac muscle dysfunction and cardiac electrical dysfunction. This text begins by reviewing the controversy surrounding the pathogenetic mechanisms of atheroma formation and its potential reversibility, including the status of coronary risk factors and benefits of primary prevention. The pathophysiologic mechanisms of pump failure and the current approach to its management are then deliberated, followed by a discussion on the rational use of vasodilators in post-infarction heart failure and pharmacotherapy of cardiogenic shock.

The rationale for the interest in the role of coronary vasospasm and thrombolytic therapy for acute myocardial infarction is also covered. This publication concludes by reviewing the approaches for the management of post-infarction ventricular tachyarrhythmias and concept of secondary prevention of sudden cardiac death.

This compilation is valuable to medical students, primary care physicians, and cardiovascular specialists.

Table of Contents



1. Pathogenesis of Coronary Atherosclerosis: Prevention of Atherogenesis

I. The Atherosclerotic Lesion

II. Pathogenesis of Atherosclerosis

III. Risk Factors in Atherogenesis

IV. Clinical Trials

V. Regression of Atheroma in Humans

VI. Regression of Atheroma in Experimental Animals


2. Hemodynamic Consequences of Myocardial Infarction and the Role of Vasodilators in Acute and Chronic Management

I. Introduction

II. Hemodynamic Consequences of Heart Failure

III. Potential Benefits of Vasodilators in Congestive Heart Failure

IV. Classification and Mechanisms of Vasodilation

V. Site of Action of the Vasodilators

VI. Vasodilator Agents: Pharmacology, Hemodynamics, and Side Effects

VII. Clinical Applications

VIII. Summary


3. Pump Failure: Role of Vasopressor Agents

I. Introduction

II. Pathophysiology

III. Role of Vasopressor Agents in the Treatment of Pump Failure

IV. Future Directions


4. Coronary Artery Spasm and Pharmacology of Coronary Vasodilators

I. Introduction

II. Coronary Artery Spasm: Evolution of Current Concepts

III. Coronary Artery Spasm and Myocardial Infarction

IV. Pathophysiological Mechanisms

V. Pharmacology of Coronary Vasodilators

VI. Summary


5. Physiologic Basis and Results of Thrombolytic Therapy in Acute Myocardial Infarction

I. Introduction

II. Physiology of Thrombus Formation and Fibrinolytic Enzyme System

III. Early Trials of Long-Duration, Late Intravenous Thrombolytic Therapy in Acute Myocardial Infarct


No. of pages:
© Academic Press 1986
Academic Press
eBook ISBN:

About the Editor

Nabil El-Sherif

C. V. Ramana Reddy

Ratings and Reviews