The Pathophysiology and Pharmacotherapy of Myocardial Infarction

1st Edition - January 28, 1986
Editors: Nabil El-Sherif, C. V. Ramana Reddy
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 7 7 1 4 - 1

The Pathophysiology and Pharmacotherapy of Myocardial Infarction deals with the advances in the pathophysiology and pharmacotherapy of acute myocardial infarction and related… Read more

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The Pathophysiology and Pharmacotherapy of Myocardial Infarction deals with the advances in the pathophysiology and pharmacotherapy of acute myocardial infarction and related complications. This book covers two major consequences—cardiac muscle dysfunction and cardiac electrical dysfunction. This text begins by reviewing the controversy surrounding the pathogenetic mechanisms of atheroma formation and its potential reversibility, including the status of coronary risk factors and benefits of primary prevention. The pathophysiologic mechanisms of pump failure and the current approach to its management are then deliberated, followed by a discussion on the rational use of vasodilators in post-infarction heart failure and pharmacotherapy of cardiogenic shock. The rationale for the interest in the role of coronary vasospasm and thrombolytic therapy for acute myocardial infarction is also covered. This publication concludes by reviewing the approaches for the management of post-infarction ventricular tachyarrhythmias and concept of secondary prevention of sudden cardiac death. This compilation is valuable to medical students, primary care physicians, and cardiovascular specialists.

Contributors

Preface

1. Pathogenesis of Coronary Atherosclerosis: Prevention of Atherogenesis

I. The Atherosclerotic Lesion

II. Pathogenesis of Atherosclerosis

III. Risk Factors in Atherogenesis

IV. Clinical Trials

V. Regression of Atheroma in Humans

VI. Regression of Atheroma in Experimental Animals

References

2. Hemodynamic Consequences of Myocardial Infarction and the Role of Vasodilators in Acute and Chronic Management

I. Introduction

II. Hemodynamic Consequences of Heart Failure

III. Potential Benefits of Vasodilators in Congestive Heart Failure

IV. Classification and Mechanisms of Vasodilation

V. Site of Action of the Vasodilators

VI. Vasodilator Agents: Pharmacology, Hemodynamics, and Side Effects

VII. Clinical Applications

VIII. Summary

References

3. Pump Failure: Role of Vasopressor Agents

I. Introduction

II. Pathophysiology

III. Role of Vasopressor Agents in the Treatment of Pump Failure

IV. Future Directions

References

4. Coronary Artery Spasm and Pharmacology of Coronary Vasodilators

I. Introduction

II. Coronary Artery Spasm: Evolution of Current Concepts

III. Coronary Artery Spasm and Myocardial Infarction

IV. Pathophysiological Mechanisms

V. Pharmacology of Coronary Vasodilators

VI. Summary

References

5. Physiologic Basis and Results of Thrombolytic Therapy in Acute Myocardial Infarction

I. Introduction

II. Physiology of Thrombus Formation and Fibrinolytic Enzyme System

III. Early Trials of Long-Duration, Late Intravenous Thrombolytic Therapy in Acute Myocardial Infarction

IV. Intracoronary Streptokinase

V. Intravenous Streptokinase

VI. Management of Patients after Thrombolytic Therapy

VII. Future Directions

References

6. Electrophysiology of Ventricular Arrhythmias in Myocardial Infarction

I. Introduction

II. Electrophysiological Mechanisms of Ventricular Arrhythmias

III. Electrophysiological Mechanisms of Ventricular Arrhythmias in Myocardial Infarction

IV. Conclusion

References

7. The Pharmacology of Antiarrhythmic Drugs

I. Introduction

II. Pharmacokinetics

III. Antiarrhythmic Drugs

IV. Summary

References

8. Mechanisms and Management of Myocardial Infarction Arrhythmias

I. Introduction

II. Mechanisms of Cardiac Arrhythmias

III. Mechanisms of Arrhythmias during Infarction

IV. Clinical Studies

V. Pharmacology of Antiarrhythmic Drugs

VI. Effects of Antiarrhythmic Drugs in Ischemie Tissue

VII. Drug Therapy of Arrhythmias during Acute Myocardial Infarction

VIII. Prophylaxis for Postinfarction Sudden Death

IX. Conclusions

References

9. Pharmacologie and Surgical Therapy of Postinfarction Ventricular Arrhythmias

I. Introduction

II. Ventricular Ectopy and Nonsustained Ventricular Tachycardia

III. Ventricular Fibrillation

IV. Ventricular Tachycardia

V. Summary

References

10. The Role of Beta Blockers in the Prevention of Sudden Cardiac Death in the Postinfarction Patient

I. Introduction

II. Methods

III. Results

IV. Discussion

V. Summary

References

Index