The Paracellular Channel - 1st Edition - ISBN: 9780128146354

The Paracellular Channel

1st Edition

Biology, Physiology and Disease

Authors: Jianghui Hou
Paperback ISBN: 9780128146354
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 500
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Description

The Paracellular Channel serves as the first volume to offer a cohesive and unifying picture of the critical functions of paracellular channels (tight junctions) in different tissues. This new class of ion channel utilizes a completely different mechanism to create ion passage pathway across the cell junction, and while they share some similarities to the transcellular pathway they differ in key aspects and thus warrant independent study. This volume outlines common principles that govern the organization and regulation of these diverse cellular structures, describes the methodology of study, and highlights pathophysiologic consequence of abnormal structure and functions of the paracellular channels in human diseases. Paracellular channels are an understudied field that may hold key insights into some of the most mysterious aspects of molecular biology and physiology, and there are very few books currently on market tackling this topic. Coverage includes biochemical, biophysical, structural, physiologic analyses of the paracellular channel, as well as new technologies for its recording and characterization.

Key Features

  • Offers integrated coverage of all key aspects of paracellular channel, an understudied field that may hold key insights into some of the most mysterious aspects of physiology
  • Targets different levels of expertise spanning from graduate students, interns and clinical fellows to seasoned researchers that study functions, regulation, and dysfunctions of different tissue barriers
  • Addresses functions, regulation, and dysfunctions of different tissue barriers
  • Provides cohesive and unifying picture that describes critical functions of paracellular channels (tight junctions) in different tissues, outlines common principles that govern the organization and regulation of these diverse cellular structures, described the methodology of studying these structures, and highlights pathophysiologic consequence of abnormal structure and functions of the paracellular channels in human diseases

Readership

Researchers and advanced students in biomedical sciences, cell biology, physiology, morphology and pharmacology

Table of Contents

1. Introduction
2. Paracellular Channel Formation
3. Paracellular Channel Recording
4. Paracellular Cation Channel
5. Paracellular Anion Channel
6. Paracellular Water Channel
7. Paracellular Channel in Organ System
8. Paracellular Channel in Human Disease
9. Paracellular Channel as Drug Target
10. Paracellular Channel Evolution
11. Perspective

Details

No. of pages:
500
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128146354

About the Author

Jianghui Hou

Jianghui Hou is an Associate Professor of Medicine, Division of Nephrology, at Washington University Saint Louis. Hou received his bachelors in biochemistry from Nanjing University, China. He received in Masters (with distinction) and Ph.D. from the University of Edinburgh. He did his postdoc in cell biology at Harvard Medical School. Dr. Hou has been at Washington University since 2009. He is a renowned expert in studying paracellular channels in different tissues, has published a number of high profile papers in this field, and has recently pioneered a novel approach for high resolution measurement of the paracellular channel permeability.

Affiliations and Expertise

Associate Professor of Medicine, Division of Nephrology, Washington University Saint Louis

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