The Ovary - 3rd Edition - ISBN: 9780128132098

The Ovary

3rd Edition

Editors: Peter Leung Eli Adashi
Hardcover ISBN: 9780128132098
Imprint: Academic Press
Published Date: 1st September 2018
Page Count: 700
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The Ovary, Third Edition includes over 60% new material and expands the sections dealing with clinical aspects of human ovarian functions and highlights advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This new edition synthesizes all of this new information at the molecular, cellular, and organismal levels and presents modern ovarian physiology in a more understandable and comparative context.

The Ovary, Third Edition looks at ovarian function from a detailed molecular and cellular level. This work examines in detail all phases of the ovarian life cycle, placing special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis.

Key Features

  • Represents an unparalleled compilation of chapters relevant to contemporary ovarian physiology
  • Provides basic and clinical research on ovarian function, abnormalities, assisted reproductive technology, and cancer
  • Highlights contemporary strategies and treatment paradigms in female factor infertility


Reproductive endocrinologists, physiologists, cell and molecular biologists, fertility/infertility specialists, as well as OB/GYNs

Table of Contents

Part I. The Ovarian Follicular Apparatus: Operational Characteristics
1. Follicle Selection in Mammalian Ovaries
2. Regulation of follicle formation and development by ovarian signaling pathway
3. Human Folliculogenesis Revisited:  The Menstrual Cycle Visualized by Ultrasonography
4. Development of the Mammalian Ovary and Follicles
5. Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism
6. Inhibin, Activin and Follistatin in Ovarian Physiology
7. Cell-cell Interactions in the Ovarian Follicles: Role of TGF-beta Superfamily Members
8. Mutations and Polymorphisms, and their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes
9. Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Part II. Oocyte Maturation and Ovulation
10. Mammalian Oogenesis – the fragile foundation of the next generation
11. Mammalian Oocyte Meiosis and Chromosome Stability
12. Oocyte Meiotic Maturation
13. Gene Expression During Oogenesis and Oocyte Development
14. Oocyte Development and Ovulation

Part III. The Corpus Luteum
15. Molecular Regulation of Progesterone Production in Corpus Luteum
16. Corpus Luteum Formation
17. Luteolysis and The Corpus Luteum of Pregnancy

Part IV. Novel Experimental Models
18. Transgenic Mouse Models in the Study of Ovarian Function
19. Genome-Wide Association Studies of Ovarian Function Disorders
20. Mitchondria Research in Human Reproduction
21. Reconstitution In Vitro of Oogenesis from Pluripotent Stem Cells
22. The Role of Mitochondria in Reproductive Function and Assisted Reproduction

Part V. Human Ovarian Pathophysiology: Select Aspects
23. Ovarian Hyperstimulation Syndrome
24. The Role of GnRH Agonist Triggering in GnRH Antagonist-Based Ovarian Stimulation Protocols
25. The Ovarian Factor in Assisted Reproductive Technology
26. The Role of Antimullerian Hormone in Assisted Reproduction
27. Polycystic Ovary Syndrome
28. Genetic and Environmental Factors in the Aetiology of Polycystic Ovary Syndrome
29. Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders
30. Environmental Contaminants and Ovarian Toxicity
31. Autologous Transplantation of Human Ovarian Tissue
32. Oncofertility: Preservation of ovarian function after a cancer diagnosis

Part VI. Human Ovarian Cancer
33. Ovarian cancers: their varied origins and pathologically implicated microenvironment
34. Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer
35. Novel Therapeutic Approaches and Targets for Ovarian Cancer
36. Molecular and Cellular Basis of Chemoresistance in Ovarian Cancer



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© Academic Press 2019
Academic Press
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About the Editor

Peter Leung

Dr. Leung is a Professor at UBC’s Department of Obstetrics & Gynecology and is Associate Dean of Graduate and Postdoctoral Education in the Faculty of Medicine at UBC. Dr. Leung received his PhD from the University of Western Ontario. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, and a Career Investigator Award from the Child and Family Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung’s research focuses on molecular aspects of hormone action in reproduction. Dr. Leung’s publication record to date includes 365 papers, 26 abstracts, 22 book chapters and 5 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for 38 PhD students and 10 MSc students, 22 postdoctoral fellows and 26 visiting scientists. The major focus of Dr. Leung’s research program is endocrine control of reproduction. Dr Leung’s laboratory is best recognized for the cloning and characterization of the gene encoding the gonadotrop.

Affiliations and Expertise

Professor, University of British Columbia, Department of Obstetrics and Gynecology, BC Women’s Hospital, Provincial Health Services Authority (PHSA)

Eli Adashi

The former Dean of Medicine and Biological Sciences at Brown University (during its 2007 renaming in honor of Mr. Warren Alpert), Dr. Adashi is an academic physician-executive, a graduate of the Harvard T.H. Chan School of Public Health program in Health Care Management (MS, 2005), and the former president of the Society for Reproductive Endocrinologists (SRE), the Society for Gynecologic Investigation (SGI), and the American Gynecological and Obstetrical Society(AGOS). Dr. Adashi received his medical degree in 1973 from the Sackler School of Medicine, completed residency training in Obstetrics and Gynecology at Tufts University (1974-77), and pursued fellowship training in the subspecialty of Reproductive Endocrinology and postdoctoral training in reproductive biology at Johns Hopkins University and at the University of California at San Diego, respectively (1977-81). Faculty positions were held at the University of Maryland (1981-1996), the University of Utah (1996-2004), and Brown University (2004-present). Prior to joining Brown University, Dr. Adashi served as the John A. Dixon Endowed Presidential Professor and Chair of the Department of Obstetrics and Gynecology at the University of Utah Health Sciences Center (1996-2004) and the founder and leader of the Ovarian Cancer Program of the Huntsman Cancer Research Institute (1999-2004). Dr. Adashi has been the recipient of continuous National Institute of Health (NIH) funding from 1985 to 2005 inclusive of a Research Career Development Award. Mentor to over 50 postdoctoral trainees, and the author or co-author of close to 400 peer-reviewed publications and over 120 book chapters/reviews, Dr. Adashi co-edited or edited 16 books in the general area of reproductive medicine with special emphasis on ovarian biology. Dr. Adashi 's work has also seen press with the New York Times, the Washington Post, the Boston Globe, the Huffington Post and several other media venues. NIH service included but was not limited to membership with the National Council of the National Institute of Child health and Human Development (NICHD)(1997-2001), the Reproductive Endocrinology Study Section (1988-1992), and the Selection Committee of the Reproductive Scientist Development Program (RSDP)(1988-2005). Dr. Adashi is the former Editor-In-Chief of Seminars in Reproductive Medicine and the former Associate Editor of Endocrinology, Journal of the Society for Gynecologic Investigation, Reproductive Medicine Review, Seminars in Reproductive Endocrinology, Reproductive Medicine Review, and Reviews in Endocrine and Metabolic Disorders. A former Franklin fellow and Senior Advisor on Global Women's Health to the Secretary of State Office of Global Women's Issues (1st term of the Obama Administration), Dr. Adashi is a member of the Advisory Council of The Hastings Center, Board of Governors of Tel Aviv University, and chair of the Medical Executive Committee and the Medical Advisory Council of the Jones Foundation for Reproductive Medicine. Dr. Adashi is a former member of the Board of Directors of Physicians for Human Rights, the Council on Foreign Relations, the Global Agenda Council on Population Growth of the World Economic Forum, and the Medicare Evidence Development & Coverage Advisory Committee (MEDCAC) of the Centers for Medicare & Medicaid Services (CMS). In addition, Dr. Adashi is a former advisor to the National Committee for Quality Assurance (NCQA), the WHO, the World Bank, the Rockefeller Foundation, and the Bill and Melinda Gates Foundation. A former Examiner and Director of the Division of Reproductive Endocrinology of the American Board of Obstetrics and Gynecology (ABOG), Dr. Adashi has served as President of the Society for Reproductive Endocrinologists (SRE), the Society for Gynecologic Investigation (SGI), and the American Gynecological and Obstetrical Society (AGOS). Elected to the NAM in 1999, Dr. Adashi has served as a member of the committees on Antiprogestins: Assessing the Science (1993), Understanding Premature Birth and Assuring Health Outcomes (2005-2006), Human Embryonic Stem Cell Research (2006-2009), and on Women's Health Research (2008-2012). In addition, Dr. Adashi served as co-chair of the Committee on Reducing Childbirth Mortality in Indonesia (2012-2013). Finally, Dr. Adashi has served both as a reviewer and a review coordinator for multiple IOM reports and as chair of the Maternal & Child Health and Human Development (IG-07) interest group (2009-2011). Dr. Adashi also served twice as a member of the Board on Health Sciences Policy. As a tenured Professor of Medical Science at Brown University, Dr. Adashi is a member of the Brown Center for Prisoner Health and Human Rights and co-directs the Healthcare in America course (a highly subscribed medical school elective) and the Healthcare Policy Concentration (a medical school elective for students with special interest in Healthcare Policy).

Affiliations and Expertise

Emeritus Professor of Medical Science, Former Dean of Medicine and Biological Sciences, Center for Prisoner Health and Human Rights, The Warren Alpert Medical School, Division of Biology and Medicine, Brown University, Providence, RI, USA

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