This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered!
n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design
n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes
n Uses figures and literature references extensively throughout
n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications
Students in medicinal chemistry, the principles of drug design, advanced organic and bioorganic chemistry, researchers in pharmacology and organic chemistry, and drug companies.
Table of Contents
Introduction. Drug Discovery, Design, and Development. Receptors.Enzymes (Catalytic Receptors). Enzyme Inhibition and Inactivation. DNA. Drug Metabolism. Prodrugs and Drug Delivery Systems.
Professor Richard B. Silverman received his B.S. degree in chemistry from The Pennsylvania State University in 1968 and his Ph.D. degree in organic chemistry from Harvard University in 1974 (with time off for a two-year military obligation from 1969-1971). After two years as a NIH postdoctoral fellow in the laboratory of the late Professor Robert Abeles in the Graduate Department of Biochemistry at Brandeis University, he joined the chemistry faculty at Northwestern University. In 1986, he became Professor of Chemistry and Professor of Biochemistry, Molecular Biology, and Cell Biology. In 2001, he became the Charles Deering McCormick Professor of Teaching Excellence for three years, and since 2004 he has been the John Evans Professor of Chemistry. His research can be summarized as investigations of the molecular mechanisms of action, rational design, and syntheses of potential medicinal agents acting on enzymes and receptors.
His awards include DuPont Young Faculty Fellow (1976), Alfred P. Sloan Research Fellow (1981-1985), NIH Research Career Development Award (1982-1987), Fellow of the American Institute of Chemists (1985), Fellow of the American Association for the Advancement of Science (1990), Arthur C. Cope Senior Scholar Award of the American Chemical Society (2003), Alumni Fellow Award from Pennsylvania State University (2008), Medicinal Chemistry Hall of Fame of the American Chemical Society (2009), the Perkin Medal from the Society of Chemical Industry (2009), the Hall of Fame of Central High School of Philadelphia (2011), the E.B. Hershberg Award for Important Discoveries in Medicinally Active Substances from the American Chemical Society (2011), Fellow of the American Chemical Society (2011), Sato Memorial International Award of the Pharmaceutical Society of Japan (2012), Roland T. Lakey Award of Wayne State University (2013), BMS-Edward E. Smissman Award of the American Chemical Society (2013), the Centenary Prize of the Royal Society of Chemistry (2
"This book is a tour de force in the title area....This book adopts a novel format that focuses on the rational chemical underpinnings to both drug discovery and drug development. It seeks to illuminate the workings of drugs at the molecular level. Thus, this book contrasts with the traditional presentation which is organized around various classes of drugs....This book would be appropriate for advanced undergraduate students and graduate students and would probably be well suited as a text for course applications, especially at the graduate level. It is strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--Bruce E. Maryanoff, R.W. Jouhnson Pharnaceutical Research Institute, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vo. 115, No.12, 1993
"For the first time the principles of medicinal chemistry/pharmacology are collected in a unified, well-organized and clearly presented fashion. It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."
--CARL KAISER, Ph.D., Director, Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION
"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way...The book will turn out to be very popular with students because the material is presented clearly...The numerous superb illustrations included are used very effectively by the author to communicate and/or clarify concepts and ideas."
--William C. Groutas, Ph.D., Professor of Chemistry, WICHITA STATE UNIVERSITY