The Node of Ranvier

The Node of Ranvier

1st Edition - January 1, 1984

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  • Editor: Joy Zagoren
  • eBook ISBN: 9780323151900

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Description

The Node of Ranvier is a collection of studies about the function, morphology, and development of the node of Ranvier from experts of different disciplines. The book covers topics such as the evolution of the structure and structure and function of the nodes of Ranvier; membrane specialization at the nodes of Ranvier; and catch-binding. Also included in the book are studies about the structural and functional relationships of ion conduction in the myelinated and demyelinated axon; functional organization of potassium channels in axons; the effects of pathological conditions and toxins on nodes of Ranvier; and nodelike membranes at extranodal sites. Physiologists, biochemists, pharmacologists, cell biologists, neurologists, and neuropathologists who would like to find out more and make a study about the node of Ranvier will find the text helpful and relevant.

Table of Contents


  • Contents

    Contributors

    Preface

    Evolutional Aspects of the Structure and Function of the Nodes of Ranvier

    I. Introduction

    II. Morphology

    III. Functional Parameters

    IV. Electrophysiological Considerations

    V. Conclusions

    References

    Membrane Specialization at the Nodes of Ranvier and Paranodal and Juxtaparanodal Regions of Myelinated Central and Peripheral Nerve Fibers

    I. Introduction

    II. The Node of Ranvier

    III. The Paranodal Region

    IV. The Juxtaparanodal Internode

    V. Developmental Studies

    VI. Possible Mechanisms of Nodal Differentiation

    VII. Effects of Demyelinating Agents

    VIII. Aberrant Nodal and Paranodal Structures

    References

    Cation Binding at the Node of Ranvier

    I. Introduction

    II. Localization of Cation-Binding Reaction Product in the Normal, Myelinated Axon

    III. Localization of Binding during Development

    IV. Cation Binding under Pathological Conditions

    V. Cation Binding in Saltatory Conduction

    VI. Conclusions

    References

    Formation and Morphology of the Nodes of Ranvier in Cultures of CNS and PNS

    I. Introduction

    II. Nodes of Ranvier

    III. Neurotoxic Effects

    IV. Conclusion

    References

    Structural and Functional Relationships of Ion Conduction in the Myelinated and Demyelinated Axon

    I. Introduction

    II. Historical Development of the Description of Saltatory Conduction

    III. Modern Study of the Molecular Architecture of Myelinated Nerve Membrane

    IV. Pathophysiology of Conduction in Demyelinated Nerve Fibers

    V. Conclusions

    References

    Structure and Function of the Cytoskeleton

    and Endomembrane Systems at the Node of Ranvier

    I. Introduction

    II. General Organization of Eucaryotic Cytoplasm

    III. Components of the Axonal Cytoskeleton and Cytomusculature

    IV. Endomembrane and Cisternal Systems of the Node and Paranode

    V. Connections between the Cytoskeleton and the Endomembrane Systems

    VI. Paranodal and Nodal Membrane Specializations as Shown by Freeze-Fracture

    VII. Conclusions

    References

    Functional Oganization of Potassium Channels in Normal and Pathological Mammalian Axons

    I. Introduction

    II. Firing Characteristics and Accommodation of Normal and Pathological Axons

    III. Potassium Channels and Stabilization of Nodal Firing Properties during Axon Maturation

    IV. Role of Potassium Conductance in Activity-Dependent Excitability Changes

    V. Electrical Field Effect Interactions in Normal and Pathological Nerve Bundles

    VI. Potassium Channel Organization in Pathological Axons

    VII. Localization of Potassium Channels during Development and Regeneration

    VIII. Concluding Remarks

    References

    Nodes of Ranvier in Pathological Conditions

    I. Introduction

    II. The Normal Nodes

    III. Pathology of the Node

    References

    Toxic Effects on the Node of Ranvier

    I. Effects of Neurotoxic Substances upon Axons

    II. Effects of Neurotoxic Substances upon Schwann Cells and the Myelin Sheath

    References

    Normal and Defective Differentiation of the Nodes of Ranvier in Neurological Mutants of the Mouse

    I. Introduction

    II. Morphological, Physiological, and Biochemical Aspects of Nodes of Ranvier in Normal, Developing, and De- or Re myelinating Peripheral Nerves

    III. Cell Interactions at the Nodes of Ranvier in Peripheral Nerves of the Neurological Mutants of the Mouse during Development and Adulthood

    IV. Conclusion

    References

    Nodelike Membrane at Extranodal Sites: Comparative Morphology and Physiology

    I. Introduction

    II. Differentiation of Nodal Membrane

    III. Differentiation of Nodelike Membrane in the Absence of Myelin: Developing Axons

    IV. Foci of Nodelike Membrane in Specialized Nonmyelinated Fibers

    V. The Initial Segment: Specialized Membrane Properties at the Encoding/Trigger Zone

    VI. Heminodes and the Invasion of Preterminal Fibers

    VII. Conclusions

    References

    Sprouting and Regeneration of Peripheral Nerve

    I. Introduction

    II. Distal and Proximal Consequences of Neural Trauma

    III. Neuronal Regeneration

    IV. The Growth Cone and the Environment

    V. Neurite Dynamics during Synapse Formation and Repression

    VI. Sprouting

    VII. Conclusions

    References

    Index

Product details

  • No. of pages: 406
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: January 1, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9780323151900

About the Editor

Joy Zagoren

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