The Neuroscience of Depression

Features, Diagnosis, and Treatment

1st Edition - March 5, 2021
Editors: Colin R Martin, Lan-Anh Hunter, Vinood B. Patel, Victor R Preedy, Rajkumar Rajendram
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 9 3 3 - 8
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 9 3 4 - 5

The Neuroscience of Depression: Features, Diagnosis and Treatment, is a comprehensive reference to the diagnosis and treatment of depression. This book provides readers with the… Read more

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code is needed.

Institutional subscription on ScienceDirect

Request a sales quote

The Neuroscience of Depression: Features, Diagnosis and Treatment, is a comprehensive reference to the diagnosis and treatment of depression. This book provides readers with the mechanisms of depression reflecting on the interplay between depression and the biological and psychosocial processes. A detailed introduction to various episodes of depression, from PTSD to post-partum depression is provided, followed by a thorough discussion on biomarkers in depression and how to diagnose depression including the Hamilton Depression Rating scale. This book also includes three full sections on treatment options for depression, including pharmacological, behavioral and other novel regimes. The Neuroscience of Depression: Features, Diagnosis and Treatment is the only resource for researchers and practitioners studying, diagnosis and treating of depression.

Part I. Depression: Introductory chapters

1. Clinical staging in depression
Lorena de la Fuente-Tomás and Maria Paz García-Portilla

2. Neurodevelopmental theory of depression
Monika Talarowska

3. Depression after pregnancy
Munn-sann Lye, Normala Ibrahim, Fathemah Abdollahi, and Yin-Yee Tey

4. Modeling maternal depression during pregnancy: Rodent models of major depressive disorder with peripartum onset
Elizabeth M. Sajdel-Sulkowska

5. Depression in mothers and mental health in children: Impact, risk factors and interventions
Yasodha Maheshi Rohanachandra

6. The neuroscience of depression: Mechanisms and treatments
Yuan-Pang Wang, Antonio Reis de Sá Junior, and Clarice Gorenstein

7. Depression in disasters and traumatic events
Mao-Sheng Ran and Man-Man Peng

8. Depression and associated Alzheimer's disease
Nikita Patil and Girdhari Lal Gupta

9. Comorbidities of depression and Parkinson's disease
Tanvi Pingale and Girdhari Lal Gupta

10. Understanding the relationship between depression and alcohol among students
Daniel Teixeira dos Santos, Guilherme de Souza Paulo Filho, Marco Aurélio dos Santos Carvalho, and Vinícius Medeiros Henriques

11. Depression in obesity
Ioannis D. Morres, Antonis Hatzigeorgiadis, and Yannis Theodorakis

12. Heart rate variability and depression
Renerio Fraguas and Bruno Pinatti Ferreira de Souza

13. Neuroinflammation and depression
B. García Bueno, K. MacDowell, J.L.M. Madrigal, and J.C. Leza

14. Interlinking antidepressants and the immune system
Katarzyna A. Lisowska, Krzysztof Pietruczuk, and Łukasz P. Szałach

Part II. Biomarkers and diagnosis

15. Assessment scoring tools of depression
Clarice Gorenstein, Elaine Henna, and Yuan-Pang Wang

16. The Beck Depression Inventory: Uses and applications
Yuan-Pang Wang and Clarice Gorenstein

17. Hamilton depression rating scale: Uses and applications
Lubova Renemane and Jelena Vrublevska

18. The patient health questionnaire (PHQ)
Maria Iglesias-González and Crisanto Diez-Quevedo

19. Screening for antenatal depression (AND) using self-report questionnaires: Conceptual issues and measurement limitations
Colin R. Martin and Caroline J. Hollins Martin

20. Edinburgh postnatal depression scale: Description and applications
Jacqueline K. Gollan, Gabrielle A. Mesches, and Isabel A. Gortner

21. The death depression scale: Description and applications
David Lester and Mahboubeh Dadfar

22. The depression anxiety stress scale: Features and applications
Jennifer C.P. Gillies and David J.A. Dozois

23. Arabic version of the two-question quick inventory of depression (QID-2-AR): Description and applications
Amani Ahmed and Muaweah Ahmad Alsaleh

24. Depression and biomarkers of cardiovascular disease
Allison J. Carroll and Olivia E. Bogucki

25. Thioredoxin as an antioxidant protein as a marker in depression
Efruz Pirdogan Aydin and Ece Turkyilmaz Uyar

26. Methods of neuroimaging in depression: Applications to resting-state functional connectivity
Moon-Soo Lee

27. Neural markers of depression in MRI
Chien-Han Lai

Part III. Pharmacological Treatments For Depression

28. Angiotensin receptor 1 blockade as an antidepression strategy
Lilla Lenart and Andrea Fekete

29. The link between cannabinoids and depression
Mohaddeseh Ebrahimi-Ghiri and Fatemeh Khakpai

30. Agomelatine: Profile and applications to depression
Trevor R. Norman

31. Bumetanide and use in depressive states
M. Tessier, A. Rezzag, C. Pellegrino, and C. Rivera

32. Linking citalopram, serotonin reuptake inhibitors, and depressed pregnant women
Marta Weinstock

33. Citalopram and usage in sleep-deprivation-induced depression
Afzal Misrani and Cheng. Long

34. Monoaminergic system and antidepressants
David Martín-Hernández, Cristina Ulecia Morón, Álvaro G. Bris, Marta P. Pereira, and Javier R. Caso

35. Duloxetine usage in depression
Bing Hu

36. Escitalopram and blonanserin as antidepressant agents linking in neurotrophic mechanisms
Wataru Ukai, Kenta Deriha, Eri Hashimoto, and Chiaki Kawanishi

37. (2R,6R)-Hydroxynorketamine as a novel antidepressant and its role in the antidepressant actions of (R,S)-ketamine
Shigeyuki Chaki and Jun-ichi Yamaguchi

38. Linking 5-hydroxytryptamine to antidepressant actions of (R)-ketamine and social stress model
Kai Zhang and Kenji Hashimoto

39. Mirtazapine: Multitarget strategies for treating substance use disorder and depression
Susana Barbosa Méndez, Luis Enrique Becerril-Villanueva, María Dolores Ponce-Regalado, and Alberto Salazar-Juárez

Part IV. Counselling, Psychotherapy and Behavioural Treatments for Depression

40. Mindfulness-based cognitive therapy and depression
Tatjana Ewais

41. Online programs for depression
Philip J. Batterham, Alison L. Calear, and Ella Kurz

42. Clay art therapy on emotion regulation: Research, theoretical underpinnings, and treatment mechanisms
Joshua K.M. Nan, Lisa D. Hinz, and V.B. Lusebrink

43. Solution-focused counseling and its use in postpartum depression
Seyed Abbas Mousavi, Somayeh Ramezani, and Ahmad Khosravi

44. Transcranial direct current stimulation (tDCS) combined with cognitive emotional training (CET) as a novel treatment for depression
Donel Martin and Stevan Nikolin

Part V. Other Aspects of Treatment: Specific Groups, Monitoring and Novel Regimens

45. Putative effects of cannabidiol in depression and synaptic plasticity
Sâmia Joca, Gabriela P. Silote, Ariandra Sartim, Amanda Sales, Francisco Guimarães, and Gregers Wegener

46. Transcutaneous auricular vagus nerve stimulation in the treatment of depression
Jian Kong, Georgia Wilson, and Peijing Rong

47. Exercise for depression as a primary and comorbid with obesity disorder: A narrative
Ioannis D. Morres, Antonis Hatzigeorgiadis, and Yannis Theodorakis

48. Acupressure and depression: a scientific narrative
Nant Thin Thin Hmwe and Sally Wai-Chi Chan

49. Potential beneficial effects of Bifidobacterium breve A1 on cognitive impairment and psychiatric disorders
Ryo Okubo, Jinzhong Xiao, and Yutaka J. Matsuoka

50. Coenzyme Q₁₀ and use in depression
Amir Sasan Bayani Ershadi and Mir-Jamal Hosseini

51. Gene expression in major depressive disorder: Peripheral tissue and brain-based studies
Kristin Mignogna and Fernando S. Goes

52. Electroconvulsive therapy for depression: Effectiveness, cognitive side effects, and mechanisms of action
Maria Semkovska

53. Prenatal depression and offspring DNA methylation
Sabrina Faleschini and Andres Cardenas

54. Treating depression with theta burst stimulation (TBS)
Ankita Chattopadhyay

Colin R Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.

Affiliations and expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Lan-Anh Hunter

Dr Lan-Anh Hunter BSc MBBS DFFP DRCOG MRCGP qualified from Guys, King’s & St. Thomas’ Medical School, London in 2001, where she developed an early interest in psychological medicine. She went on to study culture bound syndromes, whilst reading Medical Anthropology Honours degree at University College London, focusing on the cultural aspects of anorexia nervosa in her thesis. She subsequently worked in Australia and explored the psychological aspects of diabetes and its many complications on the aboriginal population. Prior to becoming a GP Principal, she lectured at Charing Cross Hospital teaching doctors in training, continuing this passion, as a GP trainer in her current role. Much has been written about depression in primary care and hence her call to this area. She specialises in psychological medicine, with training in coaching, narrative based medicine, cognitive behaviour therapy and she continues to see, support, treat and manage clinical depression on an everyday basis as a family GP in her Maidenhead practice.

Affiliations and expertise

Rosemead Surgery, Maidenhead, Berkshire, UK

Vinood B. Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and expertise

Reader, University of Westminster, London, UK

Victor R Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Affiliations and expertise

Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UK

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise

Consultant in Internal Medicine, King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia