The Neuroscience of Depression

The Neuroscience of Depression

1st Edition - March 22, 2021

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  • Editors: Colin Martin, Lan-Anh Hunter, Vinood Patel, Victor Preedy, Rajkumar Rajendram
  • eBook ISBN: 9780128180105
  • Paperback ISBN: 9780128180099

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The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.

Key Features

The Neuroscience of Depression: Features, Diagnosis and Treatment

  • Covers a pharmacological and behavioral treatment options
  • Features sections on diagnosis and biomarkers of depression
  • Discusses depression in children, teens and adults
  • Contains information on comorbidity of physical and mental conditions
  • Includes more than 250 illustrations and tables

The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet

  • Features a section on neurological and imaging, including SPECT Neuroimaging
  • Analyzes how diet and nutrition effect depression
  • Examines the molecular and cellular effects of depression
  • Covers genetics of depression
  • Includes more than 250 illustrations and tables


Researchers, graduate students, and clinicians in behavioral neuroscience, cognitive neuroscience, neurobiology, translational neuroscience, and neuropsychology

Table of Contents

  • The Neuroscience of Depression: Features, Diagnosis and Treatment

    I. Depression: Introductory Chapters
    1. Clinical staging in depression
    2. Neurodevelopmental theory of depression
    3. Depression after pregnancy
    4. Modeling maternal depression during pregnancy: rodent models of Major Depressive Disorder with Peripartum Onset
    5. Depression in mothers and mental health in children:Impact, risk factors and interventions
    6. Depression in college students
    7. Depression in disasters and traumatic events
    8. Depression and associated Alzheimer s disease
    9. Comorbidities of depression and Parkinson's disease
    10. Understanding the relationship between depression and alcohol among students
    11. Depression in obesity
    12. Depression and heart rate variability
    13. Neuroinflammation and depression
    14. Interlinking antidepressants and the immune system

    II. Biomarkers and Diagnosis
    15. Assessment scoring tools of depression
    16. The Beck Depression Inventory: uses and applications
    17. The Hamilton Depression Rating scale: uses and applications
    18. The Patient Health Questionnaire (PHQ)
    19. Screening for Antenatal Depression (AND) using self-report questionnaires: conceptual issues and measurement limitations
    20. Edinburgh Postnatal Depression Scale: description and applicationsJacqueline
    21. The Death Depression Scale: description and applications
    22. Depression Anxiety Stress Scales: Features and Applications
    23. Arabic version of the two-question Quick Inventory of Depression: description and applications (QID-2-Ar)
    24. Depressive Symptoms and Biomarkers of Cardiovascular Disease
    25. Thioredoxin as an antioxidant protein as a marker in depression
    26. Methods of neuroimaging in depression: applications to resting-state functional connectivity
    27. Neural markers of depression in MRI

    III. Pharmacological Treatments for Depression
    28. Angiotensin receptor 1 blockade as an antidepression strategy
    29. Cannabinoid CB1 receptors and antidepressant effects
    30. Agomelatine: profiles and applications to depression
    31. Bumetanide and use in depressive states
    32. Linking citalopram, serotonin reuptake inhibitors and depressed pregnant women
    33. Citalopram and usage in sleep-deprivation-induced depression
    34. Monoaminergic System and Antidepressants
    35. Duloxetine usage in depression
    36. Escitalopram and blonanserin as antidepressant agents linking in neurotrophic mechanisms
    37. Ketamine and the role of (2R,6R)-Hydroxynorketamine in depression
    38. Linking 5-Hydroxytryptamine, antidepressant actions of (R)-Ketamine and social stress model
    39. Mirtazapine: multi-target strategies for treating substance use disorder and depression

    IV. Counselling, Psychotherapy and Behavioural Treatments For Depression
    40. Mindfulness-based cognitive therapy and depression
    41. Online (web based) programs for depression
    42. Clay art therapy on emotion regulation: Research, theoretical underpinnings, & treatment mechanisms
    43. Solution-focused counselling: and use in postpartum depression
    44. Transcranial direct current stimulation (tDCS) combined with cognitive emotional training (CET) as a novel treatment for depression

    V. Other Aspects of Treatment: Specific Groups, Monitoring and Novel Regimens
    45. Putative effects of cannabidiol in depression and synaptic plasticity
    46. Tanscutaneous vagus nerve stimulation in depression
    47. Exercise for depression as a primary and comorbid with obesity disorder: a narrative
    48. Acupressure and depression: a scientific narrative
    49. Potential beneficial effects of Bifidobacterium breve A1 on cognitive impairment and psychiatric disorders
    50. Coenzyme Q and use in depression
    51. Gene expression in Major Depressive Disorder: peripheral and brain based studies
    52. Electroconvulsive therapy for depression: effectiveness, cognitive side-effects and mechanisms of action
    53. Depression and offspring DNA methylation
    54. Other Aspects of Treatment: Specific Groups, Monitoring and Novel Regimens: Treating depression with Theta burst stimulation (TBS)

    The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet

    I. Genetic Aspects Of Depression
    1. Epigenetics in depression
    Monika Talarowska
    2. Genes, depression and nuclear DNA
    Xenia Gonda
    3. Molecular aspects of postpartum depression
    Anna Landsman
    4. Genetics and epigenetics of the SLC6A4 gene in depression
    Álvaro F.L. Rios
    5. Tryptophan related genes and depression
    Tomasz Sliwinski
    6. Metalloproteinases genes and depression
    Monika Talarowska
    7. Linking gene regions jointly with environment and depression
    Erin B. Ware

    II. Molecular and Cellular Effects Of Depression
    8. Linking depression, mRNA translation and serotonin
    Jean-Claude Lacaille
    9. Changes in cortical gene expression in major depression: More evidence implicating inflammatory-related pathways in disease aetiology
    Brian Dean
    10. FKBP5 gene expression and depression
    Marcus Ising
    11. Cytokines related to depression
    Patricia Broderick
    12. Linking Interleukin-6 and Depression
    Manivel Rengasamy
    13. The role of inflammatory signaling in comorbid depression and epilepsy
    Jana D. Tchekalarova Sr.
    14. Brain inflammasomes in depression
    C. Beyer
    15. Inflammatory factors and depression in substance use disorderFrancisco
    Javier Pavon
    16. Linking Huntington disease, brain-derived neurotrophic factor and depressive-like behaviors
    Patricia Brocardo
    17. Depression and the NMDA receptor/NO/cGMP pathway
    Ana Cristina Oliveira Monteiro-Moreira
    18. Translocator protein (18 kDa TSPO) binding in depression
    Szabolcs Keri
    19. Axonal transport proteins: what they are and how they relate to depressive behaviours
    Arezo Nahavandi
    20. Molecular features of adenylyl cyclase isoforms and cAMP signaling: a link between adenylyl cyclase 7 and depression
    Tarsis F. Brust
    21. Neurobiology of depression: the role of glycogen synthase kinase 3
    Minal Sonawane, Giuseppe Aceto, Jessica Di Re, Marcello D'Ascenzo, Thomas Green and Fernanda Laezza
    22. Sortilin/NTSR3 in depression
    Jean Mazella
    23. Wnt/beta-catenin signaling pathway and antidepressant role
    Shubha Shukla
    24. The prefrontal cortex in depression: use of proteomics
    Gábor Juhász

    III. Neurological and Imaging Features
    25. SPECT Neuroimaging and depression
    Daniel G. Amen
    26. Resting-state functional magnetic resonance imaging (MRI), bipolar depression and unipolar depression
    K.K. Ellard
    27. Linking amygdala blood oxygenation-level-dependent (BOLD) activity and frontal EEG in depression
    Vadim Zotev
    28. The rostromedial tegmental nucleus: features and links with alcohol and depression
    Jiang-Hong Ye
    29. Serotonergic neurons, selective serotonin reuptake inhibitor (SSRI) resistance and major depressive disorder
    Fred H. Gage and Krishna C. Vadodaria
    30. Role of nesfatin-1 in major depression
    Ece Türkyılmaz Uyar
    31. Impact of NGF signaling in neuroplasticity during depression: Insights in neuroplasticity dependent therapeutic approaches
    Amal Chandra Mondal
    32. Depression and germ cells memory
    M.A. Alsaleh and Amani A. Ahmed

    IV. Behaviour And Psychopathological Effects
    33. Cognitive function and neurocognitive deficits in depression
    M. Semkovska
    34. Cognitive and interpersonal contributors to relationship distress and depression
    David J. A. Dozois
    35. Adolescence life stage and cognitive vulnerability to depression
    R.T. Liu
    36. Determining the cognitive performance in first episode of depression
    Maria J. Portella
    37. Body image and depression
    Päivi Maria Pylvanainen
    38. Sleep, anxiety and depression
    Kelly Sullivan
    39. Depression, anxiety and quality of life
    Keming Gao
    40. Reward Processing and Depression: Current Findings and Future Directions
    Daniel M. Mackin
    41. Sexual functioning in depressive disorders
    S. Grover

    V. Diet, Nutrition and Botanicals
    42. Linking dietary glycemic index and depression
    Sima Jafarirad
    43. Gut microbiota and Depression
    Kurosh Djafarian
    44. Linking dietary methyl donors, maternal separation and depression
    María J. Ramirez
    45. Convolvulus pluricaulis usage and depression
    Girdhari Lal Gupta
    46. Antidepressant effects of Crocus sativus (saffron) and its constituents
    Hossein Hosseinzadeh
    47. Mechanisms of action of herbal antidepressants
    Hossein Hosseinzadeh
    48. Depression, antidepressant-like effects and mechanisms of the herbal formula xiaochaihutang
    Chun fu Wu

    VI. Resources
    49. Resources in depression
    Rajkumar Rajendram

Product details

  • No. of pages: 1166
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: March 22, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128180105
  • Paperback ISBN: 9780128180099

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Lan-Anh Hunter

Dr Lan-Anh Hunter BSc MBBS DFFP DRCOG MRCGP qualified from Guys, King’s & St. Thomas’ Medical School, London in 2001, where she developed an early interest in psychological medicine. She went on to study culture bound syndromes, whilst reading Medical Anthropology Honours degree at University College London, focusing on the cultural aspects of anorexia nervosa in her thesis. She subsequently worked in Australia and explored the psychological aspects of diabetes and its many complications on the aboriginal population. Prior to becoming a GP Principal, she lectured at Charing Cross Hospital teaching doctors in training, continuing this passion, as a GP trainer in her current role. Much has been written about depression in primary care and hence her call to this area. She specialises in psychological medicine, with training in coaching, narrative based medicine, cognitive behaviour therapy and she continues to see, support, treat and manage clinical depression on an everyday basis as a family GP in her Maidenhead practice.

Affiliations and Expertise

Rosemead Surgery, Maidenhead, Berkshire, UK

Vinood Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

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