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The Neuroscience of Depression - 1st Edition - ISBN: 9780128179352

The Neuroscience of Depression

1st Edition

Genetics, Cell Biology, Neurology, Behavior, and Diet

Editors: Colin Martin Lan-Anh Hunter Vinood Patel Victor Preedy Rajkumar Rajendram
Paperback ISBN: 9780128179352
Imprint: Academic Press
Published Date: 27th March 2021
Page Count: 574
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The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.

Key Features

  • Features a section on neurological and imaging, including SPECT Neuroimaging
  • Analyzes how diet and nutrition effect depression
  • Examines the molecular and cellular effects of depression
  • Covers genetics of depression
  • Includes more than 250 illustrations and tables


Researchers, graduate students, and clinicians in behavioral neuroscience, cognitive neuroscience, neurobiology, translational neuroscience, and neuropsychology

Table of Contents

Part I. Genetic Aspects of Depression
1. Epigenetics in depression
Piotr Czarny, Katarzyna Bialek, Sylwia Ziolkowska, Monika Talarowska, and Tomasz Sliwinski
2. Genes, depression and nuclear DNA
Xenia Gonda and Peter Petschner
3. Gene expression in depression: Molecular aspects of postpartum depression
Anna Landsman
4. Genetics and epigenetics of the SLC6A4 gene in depression
M. S. Mendonça, Paula M. Mangiavacchi, and Álvaro F.L. Rios
5. Molecular basis of tryptophan metabolism disorders associated with depression
Paulina Wigner, Piotr Gałecki, and Tomasz Śliwiński
6. Metalloproteinases genes and their relationship with depression
Monika Sienkiewicz, Michał Seweryn Karbownik, Mateusz Kowalczyk, Edward Kowalczyk, and Monika Talarowska
7. Linking gene regions jointly with environment and depression
Arianna M. Gard and Erin B. Ware

Part II. Molecular and cellular effects of depression
8. Linking depression, mRNA translation, and serotonin
Emily Arsenault, Aisha Asad Ahmed, Ayeila Daneshmend, Zeynep JihadMohamad, Edna Matta-Camacho, Melissa Nyveld, Fatimeh-Frouh TaghaviAbkuh, Molly Zhang, Nahum Sonenberg, Jean-Claude Lacaille, and Argel Aguilar-Valles
9. Changes in cortical gene expression in major depressive disorders: More evidence implicating inflammatory-related pathways in disease etiology
Brian Dean
10. FKBP5 gene expression as a biomarker for treatment outcome in depression
Marcus Ising
11. Neuroimaging a cytokine storm by transducing IL-1α to hippocampal cornu ammonis: COVID-19 SARS-CoV-2
Patricia A. Broderick and Steven L. Cofresi
12. Linking interleukin-6 and depression
Manivel Rengasamy and Rebecca B. Price
13. The role of inflammatory signaling in comorbid depression and epilepsy
Jana Dimitrova Tchekalarova, Dimitrinka Atanasova, and Nikolai Lazarov
14. Brain inflammasomes in depression
Stefanie Hoffmann and Cordian Beyer
15. Inflammatory factors and depression in substance use disorder
María Flores-López, Oscar Porras-Perales, Nerea Requena-Ocaña, Nuria García-Marchena, Pedro Araos, Antonia Serrano, Manuel Jiménez-Navarro, Fernando Rodríguez de Fonseca, and Francisco Javier Pavón
16. Linking Huntington disease, brain-derived neurotrophic factor, and depressive-like behaviors
Evelini Plácido, Cristine de Paula Nascimento-Castro, Priscilla Gomes Welter, Joana Gil-Mohapel, and Patricia S. Brocardo
17. Depression and the NMDA receptor/NO/cGMP pathway
João Ronielly Campêlo Araújo and Ana Cristina de Oliveira Monteiro-Moreira
18. Translocator protein (18 kDa TSPO) binding in depression
Szabolcs Kéri
19. Axonal transport proteins: What they are and how they relate to depressive behaviors
Arezo Nahavandi and Soraya Mehrabi
20. Molecular features of adenylyl cyclase isoforms and cAMP signaling: A link between adenylyl cyclase 7 and depression
Gianna Giacoletti, Abdulwhab Shremo Msdi, Ryan Cook, and Tarsis F. Brust
21. Neurobiology of depression: The role of glycogen synthase kinase 3
Minal Sonawane, Giuseppe Aceto, Jessica Di Re, Marcello D’Ascenzo, Thomas A Green, and Fernanda Laezza
22. Sortilin/neurotensin receptor-3 and its derived peptides in depression
Jean Mazella, Marc Borsotto, and Catherine Heurteaux
23. Implication of Wnt/beta-catenin signaling and its components in depression and neuropsychiatric disorders
Akanksha Mishra, Sonu Singh, and Shubha Shukla
24. The prefrontal cortex in depression: Use of proteomics
Gábor Juhász, Vanda Tukacs, Dániel Mittli, and Katalin Adrienna Kékesi

Part III. Neurological and imaging features
25. How brain single photon emission computed topography imaging informs the diagnosis and treatment of mood disorders
Daniel Amen, Jay Faber, Muneer Ali, Nelson Bennett, Rishi Sood, and Mona Karimpour
26. Resting-state functional magnetic resonance imaging (rsfMRI) in bipolar and unipolar depression
Kristen K. Ellard, Sofia Uribe, and Christopher J. Funes
27. Linking amygdala blood oxygenation-level-dependent (BOLD) activity and frontal EEG in depression
Vadim Zotev and Jerzy Bodurka
28. The rostromedial tegmental nucleus: Features and links with alcohol and depression
Qi Kang Zuo, Wanhong Zuo, Jean Daniel Eloy, and Jiang-Hong Ye
29. Human serotonergic neurons, selective serotonin reuptake inhibitor (SSRI) resistance and major depressive disorder
Krishna C. Vadodaria, Kelly J. Heard, and Fred H. Gage
30. Role of nesfatin-1 in major depression
Ece Türkyılmaz Uyar and Efruz Pirdoğan Aydın
31. Impact of NGF signaling in neuroplasticity during depression: Insights in neuroplasticity dependent therapeutic approaches
Mir Hilal Ahmad, M. Moshahid Alam Rizvi, Mahino Fatima, and Amal Chandra Mondal

Part IV. Behaviour and Psychopathological Effects
32. Inherited depression and psychological disorders and mental illness by germ cells and their memory
Amani Ahmed and Muaweah Ahmad Alsaleh
33. Cognitive function and neurocognitive deficits in depression
Maria Semkovska
34. Cognitive and interpersonal contributors to relationship distress and depression: A review of the dyadic partner-schema model
Jesse Lee Wilde, Jennifer C.P. Gillies, and David J.A. Dozois
35. Cognitive vulnerability to depression in adolescence
Richard T. Liu, Jessica L. Hamilton, and Alexandra H. Bettis
36. Determining the cognitive performance in the first episode of depression
Muriel Vicent-Gil and Maria J. Portella
37. Body image and depression
Päivi Pylvänäinen (Maria), Anita Forsblom, Joona Muotka, and Katriina Hyvönen
38. Sleep, anxiety and depression
Li-Ting Huang and Kelly L. Sullivan
39. Depression, anxiety and quality of life
Keming Gao and Jian Zhang
40. Reward processing and depression: Current findings and future directions
Daniel M. Mackin, Brady D. Nelson, and Daniel N. Klein
41. Sexual functioning in depression
Sandeep Grover and Swapnajeet Sahoo

V. Diet, Nutrition and Botanicals
42. Linking dietary glycemic index and depression
Sima Jafarirad and Mehran Rahimlou
43. Gut microbiota and depression
Asma Kazemi and Kurosh Djafarian
44. Linking dietary methyl donors, maternal separation, and depression
Mirian Sanblas, Xabier Bengoetxea, Fermin Milagro, and Maria J. Ramirez
45. Convolvulus pluricaulis usage and depression
Priyank Shah and Girdhari Lal Gupta
46. Antidepressant activity of Crocus sativus L. and its main constituents: A review
Bibi Marjan Razavi, Azar Hosseini, and Hossein Hosseinzadeh
47. Mechanisms of action of herbal antidepressants
Mahboobeh Ghasemzadeh Rahbardar and Hossein Hosseinzadeh
48. Antidepressant-like effects and mechanisms of the herbal formula Xiaochaihutang in depression
Kuo Zhang, Jingyu Yang, and Chunfu Wu

Part VI. Resources
49. Recommended resources on the neuroscience of depression: Genetics, cell biology, neurology, behavior, and diet
Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy


No. of pages:
© Academic Press 2021
27th March 2021
Academic Press
Paperback ISBN:

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Lan-Anh Hunter

Dr Lan-Anh Hunter BSc MBBS DFFP DRCOG MRCGP qualified from Guys, King’s & St. Thomas’ Medical School, London in 2001, where she developed an early interest in psychological medicine. She went on to study culture bound syndromes, whilst reading Medical Anthropology Honours degree at University College London, focusing on the cultural aspects of anorexia nervosa in her thesis. She subsequently worked in Australia and explored the psychological aspects of diabetes and its many complications on the aboriginal population. Prior to becoming a GP Principal, she lectured at Charing Cross Hospital teaching doctors in training, continuing this passion, as a GP trainer in her current role. Much has been written about depression in primary care and hence her call to this area. She specialises in psychological medicine, with training in coaching, narrative based medicine, cognitive behaviour therapy and she continues to see, support, treat and manage clinical depression on an everyday basis as a family GP in her Maidenhead practice.

Affiliations and Expertise

Rosemead Surgery, Maidenhead, Berkshire, UK

Vinood Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

King’s College London, UK

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