The Neuroscience of Depression

The Neuroscience of Depression

Features, Diagnosis, and Treatment

1st Edition - March 5, 2021

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  • Editors: Colin Martin, Lan-Anh Hunter, Vinood Patel, Victor Preedy, Rajkumar Rajendram
  • eBook ISBN: 9780128179345
  • Paperback ISBN: 9780128179338

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The Neuroscience of Depression: Features, Diagnosis and Treatment, is a comprehensive reference to the diagnosis and treatment of depression. This book provides readers with the mechanisms of depression reflecting on the interplay between depression and the biological and psychosocial processes. A detailed introduction to various episodes of depression, from PTSD to post-partum depression is provided, followed by a thorough discussion on biomarkers in depression and how to diagnose depression including the Hamilton Depression Rating scale. This book also includes three full sections on treatment options for depression, including pharmacological, behavioral and other novel regimes. The Neuroscience of Depression: Features, Diagnosis and Treatment is the only resource for researchers and practitioners studying, diagnosis and treating of depression.

Key Features

  • Covers a pharmacological and behavioral treatment options
  • Features sections on diagnosis and biomarkers of depression
  • Discusses depression in children, teens and adults
  • Contains information on comorbidity of physical and mental conditions
  • Includes more than 250 illustrations and tables


Researchers, graduate students, and clinicians in behavioral neuroscience, cognitive neuroscience, neurobiology, translational neuroscience, and neuropsychology

Table of Contents

  • Part I. Depression: Introductory chapters
    1. Clinical staging in depression
    Lorena de la Fuente-Tomás and Maria Paz García-Portilla
    2. Neurodevelopmental theory of depression
    Monika Talarowska
    3. Depression after pregnancy
    Munn-sann Lye, Normala Ibrahim, Fathemah Abdollahi, and Yin-Yee Tey
    4. Modeling maternal depression during pregnancy: Rodent models of major depressive disorder with peripartum onset
    Elizabeth M. Sajdel-Sulkowska
    5. Depression in mothers and mental health in children: Impact, risk factors and interventions
    Yasodha Maheshi Rohanachandra
    6. The neuroscience of depression: Mechanisms and treatments
    Yuan-Pang Wang, Antonio Reis de Sá Junior, and Clarice Gorenstein
    7. Depression in disasters and traumatic events
    Mao-Sheng Ran and Man-Man Peng
    8. Depression and associated Alzheimer's disease
    Nikita Patil and Girdhari Lal Gupta
    9. Comorbidities of depression and Parkinson's disease
    Tanvi Pingale and Girdhari Lal Gupta
    10. Understanding the relationship between depression and alcohol among students
    Daniel Teixeira dos Santos, Guilherme de Souza Paulo Filho, Marco Aurélio dos Santos Carvalho, and Vinícius Medeiros Henriques
    11. Depression in obesity
    Ioannis D. Morres, Antonis Hatzigeorgiadis, and Yannis Theodorakis
    12. Heart rate variability and depression
    Renerio Fraguas and Bruno Pinatti Ferreira de Souza
    13. Neuroinflammation and depression
    B. García Bueno, K. MacDowell, J.L.M. Madrigal, and J.C. Leza
    14. Interlinking antidepressants and the immune system
    Katarzyna A. Lisowska, Krzysztof Pietruczuk, and Łukasz P. Szałach

    Part II. Biomarkers and diagnosis
    15. Assessment scoring tools of depression
    Clarice Gorenstein, Elaine Henna, and Yuan-Pang Wang
    16. The Beck Depression Inventory: Uses and applications
    Yuan-Pang Wang and Clarice Gorenstein
    17. Hamilton depression rating scale: Uses and applications
    Lubova Renemane and Jelena Vrublevska
    18. The patient health questionnaire (PHQ)
    Maria Iglesias-González and Crisanto Diez-Quevedo
    19. Screening for antenatal depression (AND) using self-report questionnaires: Conceptual issues and measurement limitations
    Colin R. Martin and Caroline J. Hollins Martin
    20. Edinburgh postnatal depression scale: Description and applications
    Jacqueline K. Gollan, Gabrielle A. Mesches, and Isabel A. Gortner
    21. The death depression scale: Description and applications
    David Lester and Mahboubeh Dadfar
    22. The depression anxiety stress scale: Features and applications
    Jennifer C.P. Gillies and David J.A. Dozois
    23. Arabic version of the two-question quick inventory of depression (QID-2-AR): Description and applications
    Amani Ahmed and Muaweah Ahmad Alsaleh
    24. Depression and biomarkers of cardiovascular disease
    Allison J. Carroll and Olivia E. Bogucki
    25. Thioredoxin as an antioxidant protein as a marker in depression
    Efruz Pirdogan Aydin and Ece Turkyilmaz Uyar
    26. Methods of neuroimaging in depression: Applications to resting-state functional connectivity
    Moon-Soo Lee
    27. Neural markers of depression in MRI
    Chien-Han Lai

    Part III. Pharmacological Treatments For Depression
    28. Angiotensin receptor 1 blockade as an antidepression strategy
    Lilla Lenart and Andrea Fekete
    29. The link between cannabinoids and depression
    Mohaddeseh Ebrahimi-Ghiri and Fatemeh Khakpai
    30. Agomelatine: Profile and applications to depression
    Trevor R. Norman
    31. Bumetanide and use in depressive states
    M. Tessier, A. Rezzag, C. Pellegrino, and C. Rivera
    32. Linking citalopram, serotonin reuptake inhibitors, and depressed pregnant women
    Marta Weinstock
    33. Citalopram and usage in sleep-deprivation-induced depression
    Afzal Misrani and Cheng. Long
    34. Monoaminergic system and antidepressants
    David Martín-Hernández, Cristina Ulecia Morón, Álvaro G. Bris, Marta P. Pereira, and Javier R. Caso
    35. Duloxetine usage in depression
    Bing Hu
    36. Escitalopram and blonanserin as antidepressant agents linking in neurotrophic mechanisms
    Wataru Ukai, Kenta Deriha, Eri Hashimoto, and Chiaki Kawanishi
    37. (2R,6R)-Hydroxynorketamine as a novel antidepressant and its role in the antidepressant actions of (R,S)-ketamine
    Shigeyuki Chaki and Jun-ichi Yamaguchi
    38. Linking 5-hydroxytryptamine to antidepressant actions of (R)-ketamine and social stress model
    Kai Zhang and Kenji Hashimoto
    39. Mirtazapine: Multitarget strategies for treating substance use disorder and depression
    Susana Barbosa Méndez, Luis Enrique Becerril-Villanueva, María Dolores Ponce-Regalado, and Alberto Salazar-Juárez

    Part IV. Counselling, Psychotherapy and Behavioural Treatments for Depression
    40. Mindfulness-based cognitive therapy and depression
    Tatjana Ewais
    41. Online programs for depression
    Philip J. Batterham, Alison L. Calear, and Ella Kurz
    42. Clay art therapy on emotion regulation: Research, theoretical underpinnings, and treatment mechanisms
    Joshua K.M. Nan, Lisa D. Hinz, and V.B. Lusebrink
    43. Solution-focused counseling and its use in postpartum depression
    Seyed Abbas Mousavi, Somayeh Ramezani, and Ahmad Khosravi
    44. Transcranial direct current stimulation (tDCS) combined with cognitive emotional training (CET) as a novel treatment for depression
    Donel Martin and Stevan Nikolin

    Part V. Other Aspects of Treatment: Specific Groups, Monitoring and Novel Regimens
    45. Putative effects of cannabidiol in depression and synaptic plasticity
    Sâmia Joca, Gabriela P. Silote, Ariandra Sartim, Amanda Sales, Francisco Guimarães, and Gregers Wegener
    46. Transcutaneous auricular vagus nerve stimulation in the treatment of depression
    Jian Kong, Georgia Wilson, and Peijing Rong
    47. Exercise for depression as a primary and comorbid with obesity disorder: A narrative
    Ioannis D. Morres, Antonis Hatzigeorgiadis, and Yannis Theodorakis
    48. Acupressure and depression: a scientific narrative
    Nant Thin Thin Hmwe and Sally Wai-Chi Chan
    49. Potential beneficial effects of Bifidobacterium breve A1 on cognitive impairment and psychiatric disorders
    Ryo Okubo, Jinzhong Xiao, and Yutaka J. Matsuoka
    50. Coenzyme Q10 and use in depression
    Amir Sasan Bayani Ershadi and Mir-Jamal Hosseini
    51. Gene expression in major depressive disorder: Peripheral tissue and brain-based studies
    Kristin Mignogna and Fernando S. Goes
    52. Electroconvulsive therapy for depression: Effectiveness, cognitive side effects, and mechanisms of action
    Maria Semkovska
    53. Prenatal depression and offspring DNA methylation
    Sabrina Faleschini and Andres Cardenas
    54. Treating depression with theta burst stimulation (TBS)
    Ankita Chattopadhyay

Product details

  • No. of pages: 592
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: March 5, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128179345
  • Paperback ISBN: 9780128179338

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Lan-Anh Hunter

Dr Lan-Anh Hunter BSc MBBS DFFP DRCOG MRCGP qualified from Guys, King’s & St. Thomas’ Medical School, London in 2001, where she developed an early interest in psychological medicine. She went on to study culture bound syndromes, whilst reading Medical Anthropology Honours degree at University College London, focusing on the cultural aspects of anorexia nervosa in her thesis. She subsequently worked in Australia and explored the psychological aspects of diabetes and its many complications on the aboriginal population. Prior to becoming a GP Principal, she lectured at Charing Cross Hospital teaching doctors in training, continuing this passion, as a GP trainer in her current role. Much has been written about depression in primary care and hence her call to this area. She specialises in psychological medicine, with training in coaching, narrative based medicine, cognitive behaviour therapy and she continues to see, support, treat and manage clinical depression on an everyday basis as a family GP in her Maidenhead practice.

Affiliations and Expertise

Rosemead Surgery, Maidenhead, Berkshire, UK

Vinood Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

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