The Neuroscience of Autism Spectrum Disorders

1st Edition

Editors: Joseph Buxbaum Patrick Hof
Hardcover ISBN: 9780123919243
eBook ISBN: 9780123919304
Imprint: Academic Press
Published Date: 25th October 2012
Page Count: 496
113.00 + applicable tax
91.00 + applicable tax
149.95 + applicable tax
Compatible Not compatible
VitalSource PC, Mac, iPhone & iPad Amazon Kindle eReader
ePub & PDF Apple & PC desktop. Mobile devices (Apple & Android) Amazon Kindle eReader
Mobi Amazon Kindle eReader Anything else

Institutional Access


Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder.  New research is leading to greater understanding of and ability to treat the disorder at an earlier age.  It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention.

Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years.  With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models.  Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage.  Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise.

Key Features

  • Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions
  • Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists
  • Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available


Neuroscientists at all levels interested in neurodevelopmental disorders and autism, autism specialists looking to expand their expertise

Table of Contents



Section I: Autism Spectrum Disorders

Chapter 1.1. Epidemiology of Autism Spectrum Disorders


Selection of Studies

Study Designs

Prevalence Estimations

Time Trends in Prevalence and Their Interpretation

Other Correlates: Race, Immigrant, and Socioeconomic Status


Challenges and Future Directions

Suggested Reading


Chapter 1.2. The Behavioral Manifestations of Autism Spectrum Disorders

Historical Perspectives on ASD Behavioral Manifestations

Core Features of ASD

Heterogeneity in Behavioral Manifestations of ASD

Diagnosis and Classification of ASD

Summary and Conclusions


Chapter 1.3. Early Manifestations of Autism Spectrum Disorders

Early Biological Markers

Behavioral Manifestations in Retrospective Reports

Prospective Studies

Theoretical Considerations

Clinical Implications


Chapter 1.4. Asperger Syndrome and its Relationships to Autism

Diagnostic Concept

Epidemiology and Comorbidity

Etiology and Pathophysiology


Treatment, Interventions, and Outcome

Developmental Course and Outcome

Future Directions


Chapter 1.5. Behavioral and Psychosocial Interventions for Individuals with ASD

Early Intensive Behavioral Intervention

School-Based Treatment Approaches

Interventions Addressing Socialization Impairments

Communication Interventions

Treatments for Behavioral and Psychiatric Problems

Anxiety-Management Interventions

Auxiliary and Complementary/Alternative Treatment Approaches

Future Directions for Behavioral and Psychosocial Interventions in ASD


Chapter 1.6. Current Trends in the Pharmacolo


No. of pages:
© Academic Press 2013
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Joseph Buxbaum

Dr. Joseph Buxbaum is a world-renowned molecular geneticist who has been intimately affiliated with the Seaver Autism Center since joining the faculty at Mount Sinai in 1997. Dr. Buxbaum was recruited in part to establish a molecular genetics program in autism spectrum conditions within Mount Sinai. As such, he was the Director of Molecular Genetics in the Seaver Autism Center for seven years and took over Directorship of the Seaver Autism Center itself in 2008. Dr. Buxbaum has focused on understanding the molecular and genetic basis of autism spectrum conditions, which will allow for a better understanding of what causes them, leading to the development of novel therapeutics for the negative aspects of these disorders. Additionally, Dr. Buxbaum heads the Laboratory of Molecular Neuropsychiatry, which has taken the findings of the causes of autism and translated them into animal models where therapeutic approaches can be evaluated. In this context, Dr. Buxbaum has established the Autism Model Systems Initiative, which makes use of multiple experimental systems to develop and evaluate novel therapeutics in autism spectrum conditions. Dr. Buxbaum has taken the lead in collaborations with multiple independent sites to ensure that the best science in the service of the families is carried out. Dr. Buxbaum is a lead investigator in the Autism Genetics Consortium, the Autism Genome Project, and the Autism Case Control Cohort, and is a part of the Psychiatric Genetics Consortium. These large Consortia have the benefit of advancing the best science at the fastest pace. As the founder and co-leader of the Autism Sequencing Consortium, Dr. Buxbaum is part of an international group of scientists who share autism samples, data, and ideas in order to accelerate our understanding of the causes and treatments of autism. Dr. Buxbaum, the G. Harold and Leila Y. Mathers Professor, has received numerous awards for his research. He has received recognition from the American College

Affiliations and Expertise

Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA

Patrick Hof

Dr. Hof is the Irving and Dorothy Regenstreif Research Professor of Neuroscience and the Vice-Chair of the Department of Neuroscience at the Icahn School of Medicine at Mount Sinai in New York. He also leads the Center of Excellence on Brain Aging of the Friedman Brain Institute. His laboratory has extensive expertise in the pathology of neuropsychiatric disorders and has established an international reputation in quantitative approaches to neuroanatomy and studies of brain evolution. Dr. Hof earned his MD from the University of Geneva, School of Medicine in Switzerland. He came to the USA as a postgraduate fellow at the Research Institute of Scripps Clinic, La Jolla, CA. In 1989 he came to Mount Sinai School of Medicine as a Senior Research Associate and joined the Faculty there in 1990. He is also a Professor of Geriatrics and Ophthalmology at Mount Sinai. Dr. Hof's research is directed towards the study of selective neuronal vulnerability in dementing illnesses and aging using classical neuropathologic as well as modern quantitative morphologic methods to determine the cellular features that render the human brain uniquely vulnerable to degenerative disorders. Dr. Hof also conducts analyses of the distribution and connectivity patterns of pyramidal neuron subpopulations in the macaque monkey cerebral cortex in young and very old animals to study possible age-related changes in the neurochemical characteristics of the neurons of origin of corticocortical projections. He develops stereologic, high-resolution morphometric, and imaging tools for the quantitative study of neuroanatomical specimens and brain atlas development. Among his major contributions, Dr. Hof demonstrated that specific neurons are selectively vulnerable in dementing disorders such as Alzheimer’s disease. He has made contributions to quantifying the differences between normal aging brains and Alzheimer’s disease, as well as other mental illnesses such as schizophrenia and autism. Dr. Hof i

Affiliations and Expertise

Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA