The Neuronal Codes of the Cerebellum - 1st Edition - ISBN: 9780128013861, 9780128016756

The Neuronal Codes of the Cerebellum

1st Edition

Editors: Detlef Heck
eBook ISBN: 9780128016756
Paperback ISBN: 9780128013861
Imprint: Academic Press
Published Date: 21st October 2015
Page Count: 280
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Description

The Neuronal Codes of the Cerebellum provides the most updated information on what is known on the topics of the cerebellum’s anatomy and single cell physiology, two areas where there has been a gap in knowledge regarding the specific codes it uses to process information internally and convey commands to other brain regions. This has created difficulties for researchers and clinicians looking to develop an understanding of the mechanisms by which it contributes to behavior and how its dysfunction causes neurological symptoms.

Focused on findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes, this edited volume will aid scientists in overcoming that knowledge gap, also serving as the first resource to broadly address the different aspects of spike coding in the cerebellum that focuses on spike train analysis.

Key Features

  • Compiles current knowledge about functioning of the cerebellum on a cellular basis and how information is encoded in the cerebellum
  • Highlights findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes
  • Contents include an introduction to the cerebellum and experimental/theoretical techniques, as well as the function of cerebral coding during disorder, learning, behavior generation, motor behavior, and more
  • Bridges the gap for cerebellar researchers between single cell biophysics/anatomic studies and behavioral studies
  • Incorporates various in vivo approaches with different behavioral paradigms in primates and rodents, modeling studies of coding, and in vitro approaches

Readership

Basic and clinical neuroscientists studying cerebellar disorders, systems neuroscientists, modelers and theoreticians

Table of Contents

  • Foreword
  • Preface
  • Chapter 1. Signaling of Predictive and Feedback Information in Purkinje Cell Simple Spike Activity
    • Introduction
    • Purkinje Cell Discharge Signals Many Features of Movements
    • Purkinje Cell Discharge and Motor Errors
    • Computational Framework for Cerebellar Information Processing
    • Predictive and Feedback Signaling in Purkinje Cell Simple Spike Firing
    • Integration of Simple Spike Kinematic and Error Signals
    • Conclusions
  • Chapter 2. Deep Cerebellar Nuclei Rebound Firing In Vivo: Much Ado About Almost Nothing?
    • Introduction
    • The Computational Principles of the Cerebellum
    • The Deep Cerebellar Nuclei: The Cerebellum’s Gateway to the Brain
    • Rebound Depolarization: A Potential Feature of Spontaneously Active Neurons
    • Low-Threshold T-type Calcium Channels and Rebound Firing
    • Rebound Firing: An Intriguing and Effective Coding Mechanism that Converts Inhibitory Inputs to Excitatory Ones
    • Rebound Firing in the Deep Cerebellar Nuclei Neurons: A Prominent Biophysical Feature
    • Deep Cerebellar Nuclei Rebound Firing: The Devil is in the Details
    • Physiological Rebound Firing In Vivo
    • Conclusions
  • Chapter 3. Classical Conditioning of Timed Motor Responses: Neural Coding in Cerebellar Cortex and Cerebellar Nuclei
    • Behavioral Aspects of Eyeblink Conditioning
    • Neural Circuits Engaged during Eyeblink Conditioning
    • Neural Plasticity in the Cerebellar Cortex and Cerebellar Nuclei
    • Conclusions
    • Conflict of Interest
  • Chapter 4. How the Vestibulocerebellum Builds an Internal Model of Self-motion
    • Introduction
    • Basic Organization of the Peripheral Vestibular System
    • Framework of The Internal Model
    • Tilt- and Translation-Selective Neurons in the Cerebellum
    • Spatiotemporal Tuning
    • Revealing the Internal Model Computations
    • Discussion
    • List of Abbreviations
    • Mathematical Variables
  • Chapter 5. Modeling the Generation of Cerebellar Nuclear Spike Output
    • Introduction
    • Cerebellar Nucleus Neurons as Simple Inverters
    • Modeling Rebound Responses
    • Time-Locking, Synchrony Coding, and the Effect of Irregularity
    • Conclusions
  • Chapter 6. Cerebrocerebellar Loops in the Rodent Brain
    • Introduction
    • The Corticocerebellar Pathway
    • Mossy Fibers
    • Climbing Fibers
    • Parallel Fibers
    • Cerebellocerebral Connections
    • Functional Mapping of the Cerebellocerebral Connections
    • Conclusion
  • Chapter 7. Cerebellar Neuronal Codes—Perspectives from Intracellular Analysis In Vivo
    • Introduction
    • The Configuration of the Cerebellar Cortical Network
    • The Flow of Information Through the Cerebellar Neuronal Network
    • Spike Encoding in the Cerebellar Neurons
    • Distributed Neuronal Representations
    • Conclusions
  • Chapter 8. The Role of the Cerebellum in Optimizing Saccades
    • The Oculomotor Vermis: The Major Cerebellar Site of Saccades and Saccadic Adaptation
    • The Caudal Fastigial Nucleus: A Gateway for Saccade-Related Signals Originating from the Oculomotor Vermis
    • Summary
  • Chapter 9. Coordination of Reaching Movements: Cerebellar Interactions with Motor Cortex
    • Anatomical Connectivity Suggests Distinct Roles for the Dentate and Interpositus Nuclei in the Motor System Hierarchy
    • Deep Cerebellar Nuclei Neurons Have High Spontaneous Firing Rates about Which Movement-Related Modulation Occurs
    • Relative Timing of Dentate and Interpositus Activity with Respect to Movement Onset
    • Temporal Correlation with Sensory Cues or Motor Responses
    • Deep Cerebellar Nuclei Neurons Tend to Show Increased Activity During Movement
    • The Coding of Movement-Related Parameters in the Deep Cerebellar Nuclei
    • Does Specific Information about Movement Parameters Get Sent to Motor Cortex from the Deep Cerebellar Nuclei?
    • Future Directions and Concluding Thoughts
  • Chapter 10. A Spatiotemporal Hypothesis on the Role of 4- to 25-Hz Field Potential Oscillations in Cerebellar Cortex
    • Introduction
    • Synchronization and Oscillations in Cerebellar Circuits
    • Cerebellar Cortex 4- to 25-Hz Oscillations
    • Spatiotemporal Aspects of Granule Cell Layer Synchronization
    • Circuit Interactions—A Potential Efference Copy Role?
    • Conditions Supporting A Predictive Sensorimotor Dialog
    • Granule Cell Layer Oscillations and Internal Models
    • Conclusion—and Back to the Hockey …
  • Chapter 11. Single-Neuron and Network Computation in Realistic Models of the Cerebellar Cortex
    • Introduction
    • Biophysically Detailed Models of the Cerebellar Neurons and Microcircuits
    • Large-Scale Spiking Models of the Olivocerebellar Network
    • Real-Time Models for Closed-Loop Robotic Simulations of Cerebellar Learning and Control
    • Conclusions
    • List of Abbreviations
  • Index

Details

No. of pages:
280
Language:
English
Copyright:
© Academic Press 2016
Published:
Imprint:
Academic Press
eBook ISBN:
9780128016756
Paperback ISBN:
9780128013861

About the Editor

Detlef Heck

Associate Professor for UTHSC’s Dept. of Anatomy and Neurobiology, as well as a Visiting Scientist at The Salk Institute for Biological Studies and the Howard Hughes Medical Institute. Dr. Heck's primary research foci are the neuronal foundations of motor/cognitive brain functions and their disorders and the role of coordinated dynamic brain activity in normal and pathological brain function. He serves as Associate Editor for Frontiers in Systems Neuroscience, Review Editor for Frontiers in Neurogenomics, and Editorial Board member for Neuroscience. He was Organizer/Chair for the 2013 SFN symposium on Neuronal Codes and has authored numerous journal articles and book chapters on topics directly related to the proposed.

Affiliations and Expertise

Associate Professor, Dept. of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA