The Neuroendocrine Immune Network in Ageing, Volume 4

1st Edition

Print ISBN: 9780444550224
eBook ISBN: 9780080479668
Imprint: Elsevier Science
Published Date: 24th July 2004
Page Count: 456
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The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.

Table of Contents

I. Introduction.
Evolutionary aspects for the neuroendocrine immune network and ageing (R.H. Straub).

II. Ageing of the immune system.
Immunosenescence (R. Solana, G. Pawelec). Zinc-binding proteins (metallothionein and α-2 macroglobulin) as potential biological markers of immunosenescence (E. Mocchegiani et al.). Neutrophil ageing and immunosenescence (S.K. Butcher et al.). Apoptosis and ageing (A. Larbi et al.). MHC-unrestricted cytotoxicity in ageing (M. Provinciali, A. Donnini, R.E. Francesca). Major histocompatibility complex polymorphisms and ageing (G. Candore et al.).

III. Ageing of the endocrine system.
Neuroplascticity in the human hypothalamus during ageing (M.A. Hofman, D.F. Swaab). The role of growth hormone signalling in the control of ageing (A. Bartke et al.). Ageing and the adrenal cortex (V. Lamounier-Zepter, S.R. Bornstein). Hormonal changes in ageing men (E. Plas, S. Madersbacher, P. Berger). Ageing and the endocrine circadian system (Y. Touitou, E. Haus). Melatonin rhythms, melatonin supplementation and sleep in old age (R.F. Riemersma et al.).

IV. Ageing of the nervous system.
Age-related changes of the human autonomic nervous system (M. Agelink, R. Malessa, D. Ziegler). Age-related alterations in autonomic nervous innervation (D.L. Bellinger, K.S. Madden, D. Lorton). Ageing and the neuroendocrine system of the gut (M. El-Salhy). Modulating effects of nutrition on brain ageing (C. Bertoni-Freddari et al.). Ageing-related role of nitric oxide in the brain (S. Mariotto et al.).

V. Links between one global system and another global system during the ageing process.
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" a welcome addition to biogerontological literature...the wealth of information provided with respect to the ageing brain, the immune system and the hormonal system is definately highly useful to venture into other areas of biogerentology." - BIOGERONTOLOGY (2005) "...offers a good overview of some of the studies carried out to help address these questions, focusing particularly on the neuro-endocrine-immune axis...Overall, this text offers a good overview of the aging of the immune, neural and endocrine systems, and enables the appreciation of how biological aging of one system influences the other." -Meharvan Singh, PhD, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, U.S.A. (2005)