The Neurobiology, Physiology, and Psychology of Pain

The Neurobiology, Physiology, and Psychology of Pain

1st Edition - November 9, 2021

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  • Editors: Rajkumar Rajendram, Victor Preedy, Vinood Patel, Colin Martin
  • Paperback ISBN: 9780128205891
  • eBook ISBN: 9780128206089

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The Neurobiology, Physiology and Psychology of Pain focuses on bettering readers’ understanding of acute and chronic pain. Featuring chapters on neurotransmitters, pharmacology, and brain imaging, this volume discusses, in detail, the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. The translational work in this area has applicability for neurologists, anesthesiologists, pharmacologists, and anyone working in the intersection of these areas. This volume is integral for anyone interested in the molecular underpinnings of pain at every level.

Key Features

  • Provides comprehensive coverage on a broad range of topics related to the neuroscience of pain
  • Contains an abstract, key facts, a mini dictionary of terms, and summary points to aid in understanding in each chapter
  • Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain
  • Contains unique topics that will help readers navigate key areas for research and further clinical recommendations


Neurologists, anesthesiologists, pharmacologists, physiologists, psychologists, doctors, health care workers and experts in behaviour. Academic libraries that covers the neuroscience of pain, anesthetics and analgesics. Undergraduates, postgraduate, lecturers, academic professors, and graduate students and trainees in the basic sciences or clinical disciplines who have an interest in pain mechanisms, diagnosis and/or management

Table of Contents

  • I. Molecular and cellular aspects
    1. Gene expression, KCNQ/Kv7 channels and neuropathic pain
    Q. Yang and Zizhen Wu
    2. The NTRK1 gene and congenital insensitivity to pain
    Maryam Sobhani
    3. Prdm12, a key transcriptional regulator of the nociceptive lineage
    Eric Joseph Bellefroid
    4. Linking the genetics of fibromyalgia and painFernando
    5. Fentanyl: Polymorphisms, and adverse events
    Ana M. Peiro
    6. Propofol anesthesia and molecular changes in the brain
    Vesna Pesic
    7. Protein Kinase G is a Molecular Switch for Pain
    Y-J Sung
    8. Adrenergic agonists and the mu opioid receptor
    Robert Root-Bernstein
    9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic systemL
    Hipolito, Yolanda Campos-Jurado, Javier Cuitavi Javier, Natalia Landsberg and Jesús David Lorente
    10. Clinacanthus nutans, analgesia and the l-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway
    Zainul Amiruddin Zakaria
    11. alpha2/3-selective GABAA receptor PAMs as pain medications
    Jeffrey Witkin and Rok Cerne
    12. alpha5GABAA receptors and their role in pain perception
    Rodolfo Delgado-Lezama, Úrzula Franco-Enzástiga, Yarim De la Luz-Cuellar, Luis Eduardo Hernández-Reyes, Guadalupe Raya-Tafolla, Janet Murbartián, Vinicio Granados-Soto and Jorge Elías Torres-López
    13. ATP sensitive potassium channels in pain and analgesia
    Celina MC Lotufo, Tais Campos Lima and Débora Oliveira Santos
    14. Astrocyte-neuron lactate shuttle and pain
    Masahiro Ohsawa and Keisuke Miyamoto
    15. Nociception and sweet solutions: applications to inflammatory pain
    KHawla Nuseir
    16. Interlinking Interleukin-33 (IL-33), neuroinflammation and neuropathic pain
    Camila Ferraz, Fernanda Soares Rasquel-Oliveira, Sergio Marques Borghi, Anelise Franciosi, Thacyana Carvalho, Telma Saraiva-Santos, Nayara Anitelli Artero, Rubia Casagrande and Waldiceu A. Verri Jr.
    17. Neurons of the parabrachial nucleus, nociceptive input and pain pathways
    Masashi Fujitani
    18. Anterior cingulate cortex, pain perception and pathological neuronal plasticity during chronic pain
    Fernando Kasanetz
    19. Sleep deprivation headaches and Fos immunohistochemistry
    JeongWook Park and Seonghoon Kim
    20. Antinociceptive glucagon-like peptides
    Duygun Altıntaş Aykan
    21. Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs)
    Hee Chul Han and Eui Ho Park
    22. TRPM -8 receptor and menthol in pain management
    Merja Kokki

    II. Physiology, imaging and physical recordings
    23. Anesthetic and proconvulsant effects of ketamine on EEG
    Shaila Gowda and Charles Akos Szabo
    24. Electroencephalography and anesthetic doses of ketamine
    Jamie Sleigh
    25. Linking heart function and analgesia
    Giustino Varrassi, Giorgia Saltelli, Antonella Paladini and Martina Rekatsina
    26. Computed Tomography-guided procedures for epidural injections
    Semih Gungor
    27. Chronic pain: Linking deep brain stimulation and sensory functional MRI
    Witold Henryk Polanski and Johann Klein
    28. Neurocognition and placebo analgesia: linking in functional magnetic resonance imaging
    Sara Palermo
    29. Linking the cortex, functional spectroscopy and pain: features and applications
    Wolnei Caumo Sr.
    30. Muscle origins of myofascial pain syndrome
    Eva María Martinez-Jiménez

    III. Psychology and Behaviour
    31. Behavioral markers of pain
    Scott Holmes, Aisling E. Quinlan and Meghan Pierce
    32. Adverse life events, sensitization of spinal nociception, and chronic pain risk
    Jamie Lynn Rhudy and Natalie Hellman
    33. Cognitive-affective modulation of pain: The Placebo and nocebo phenomena and their impact on pain treatment
    Sergiu Albu, Hans Linsenbardt and Mary Meagher
    34. Nociception-related behavioral phenotypes in adult zebrafish
    Fabiano Vargas Costa Sr.
    35. Pain, implantable pain devices and psychosocial aspects as a narrative
    K. Chakravarthy and Vishal Varshney
    36. Influence of psychological factors in myofascial pain
    César Calvo-Lobo Sr.

    IV. Resources
    37. Resources
    Rajkumar Rajendram

Product details

  • No. of pages: 458
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: November 9, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128205891
  • eBook ISBN: 9780128206089

About the Editors

Rajkumar Rajendram

Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy’s, King’s, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King’s College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.

Affiliations and Expertise

Visiting Lecturer, Division of Diabetes and Nutritional Sciences, King’s College London, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Vinood Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, UK

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

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