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The Neurobiology of Aging and Alzheimer Disease in Down Syndrome - 1st Edition - ISBN: 9780128188453

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

1st Edition

Editors: Elizabeth Head Ira Lott
Paperback ISBN: 9780128188453
Imprint: Academic Press
Published Date: 1st September 2021
Page Count: 400
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The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena.

Key Features

  • Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome
  • Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age
  • Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research


Researchers, investigators, PhD students and postdocs as well as clinicians in the fields of aging, Down syndrome and Alzheimer’s disease

Table of Contents

  1. Introduction
    2. Neurobiology of aging and Alzheimer disease: Amyloid and tau
    3. Neurobiology of aging and Alzheimer disease: Inflammation
    4. Neurobiology of aging and Alzheimer disease: Cerebrovascular pathology
    5. Neurobiology of aging and Alzheimer disease: Other (ox stress, mTOR, etc)
    6. Fluid biomarkers: CSF
    7. Fluid biomarkers: Plasma
    8. Fluid biomarkers: Exosomes
    9. Fluid biomarkers: Proteomics/lipidomics/metabolomics
    10. Neuroimaging: Structural
    11. Neuroimaging: Connectivity
    12. Neuroimaging: Functional (vascular/spectroscopy)
    13. Neuroimaging: Amyloid and tau imaging
    14. Genetic risk factors
    15. Clinical neurobiology of aging and AD in DS
    16. Current treatments for AD in DS
    17. Designing clinical trials for AD in DS
    18. Is AD in DS similar to AD in the general population
    19. Future directions


No. of pages:
© Academic Press 2021
1st September 2021
Academic Press
Paperback ISBN:

About the Editors

Elizabeth Head

Elizabeth Head

Dr. Head received a Masters in Psychology and a Ph.D. in Neuroscience from the University of Toronto, Canada. She received postdoctoral training at the Institute for Brain Aging & Dementia at the University of California – Irvine. Dr. Head moved to the University of Kentucky in January of 2009 and was a Professor and Associate Director of Education at the Sanders-Brown Center on Aging. In 2019, she returned to the University of California at Irvine, where she is a Professor and Vice Chair for Research in the Department of Pathology & Laboratory Medicine. Dr. Head has dedicated over 20 years to the study of aging and Alzheimer’s disease with a focus on people with Down syndrome. The goal of her research is to help develop interventions that will promote healthy aging in people with Down syndrome.

Affiliations and Expertise

Professor, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA

Ira Lott

Ira Lott

Dr. Lott is an Emeritus Professor of Pediatrics and Neurology at the University of California, Irvine. His training was at the Massachusetts General Hospital, Harvard Medical School and he was appointed as the first Clinical Director of the Eunice Kennedy Shriver Center for people with intellectual disability. Since his recruitment to UCI in 1983, he has served as Division chief in pediatric neurology, Chair of Pediatrics and Associate Dean for Clinical Neuroscience. Dr. Lott’s research on development and aging in people with Down syndrome has been continuously funded by the National Institutes of Health for over 25 years. He has received award recognition for his work at the international, national and state levels. Having trained generations of medical students and resident physicians, Dr. Lott’s approach focuses on the intersection between neuroscience and clinical practice.

Affiliations and Expertise

Founding Director, Down Syndrome Program, University of California, Irvine, CA, USA

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