Secure CheckoutPersonal information is secured with SSL technology.
Free ShippingFree global shipping
No minimum order.
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena.
- Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome
- Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age
- Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research
Researchers, investigators, PhD students and postdocs as well as clinicians in the fields of aging, Down syndrome and Alzheimer’s disease
2. Neurobiology of aging and Alzheimer disease: Amyloid and tau
3. Neurobiology of aging and Alzheimer disease: Inflammation
4. Neurobiology of aging and Alzheimer disease: Cerebrovascular pathology
5. Neurobiology of aging and Alzheimer disease: Other (ox stress, mTOR, etc)
6. Fluid biomarkers: CSF
7. Fluid biomarkers: Plasma
8. Fluid biomarkers: Exosomes
9. Fluid biomarkers: Proteomics/lipidomics/metabolomics
10. Neuroimaging: Structural
11. Neuroimaging: Connectivity
12. Neuroimaging: Functional (vascular/spectroscopy)
13. Neuroimaging: Amyloid and tau imaging
14. Genetic risk factors
15. Clinical neurobiology of aging and AD in DS
16. Current treatments for AD in DS
17. Designing clinical trials for AD in DS
18. Is AD in DS similar to AD in the general population
19. Future directions
- No. of pages:
- © Academic Press 2021
- 1st September 2021
- Academic Press
- Paperback ISBN:
Dr. Head received a Masters in Psychology and a Ph.D. in Neuroscience from the University of Toronto, Canada. She received postdoctoral training at the Institute for Brain Aging & Dementia at the University of California – Irvine. Dr. Head moved to the University of Kentucky in January of 2009 and was a Professor and Associate Director of Education at the Sanders-Brown Center on Aging. In 2019, she returned to the University of California at Irvine, where she is a Professor and Vice Chair for Research in the Department of Pathology & Laboratory Medicine. Dr. Head has dedicated over 20 years to the study of aging and Alzheimer’s disease with a focus on people with Down syndrome. The goal of her research is to help develop interventions that will promote healthy aging in people with Down syndrome.
Professor, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
Dr. Lott is an Emeritus Professor of Pediatrics and Neurology at the University of California, Irvine. His training was at the Massachusetts General Hospital, Harvard Medical School and he was appointed as the first Clinical Director of the Eunice Kennedy Shriver Center for people with intellectual disability. Since his recruitment to UCI in 1983, he has served as Division chief in pediatric neurology, Chair of Pediatrics and Associate Dean for Clinical Neuroscience. Dr. Lott’s research on development and aging in people with Down syndrome has been continuously funded by the National Institutes of Health for over 25 years. He has received award recognition for his work at the international, national and state levels. Having trained generations of medical students and resident physicians, Dr. Lott’s approach focuses on the intersection between neuroscience and clinical practice.
Founding Director, Down Syndrome Program, University of California, Irvine, CA, USA
Elsevier.com visitor survey
We are always looking for ways to improve customer experience on Elsevier.com.
We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit.
If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website.
Thanks in advance for your time.