The Movement Of Molecules Across Cell Membranes

PrefaceGlossary of SymbolsChapter 1 The Anatomy of the Plasma Membrane 1.1 Some Considerations of Methodology 1.2 Structure and Composition of the Cell Membrane 1.3 The Structure of Myelin Forms—A Model System for the Cell Membrane 1.4 Nerve Myelin 1.5 Physical Stability of the Bimolecular Lipid Leaflet 1.6 Surface Tension of the Cell 1.7 ConclusionsChapter 2 General Aspects of Diffusion across Membranes 2.1 Permeability and Diffusion Coefficients 2.2 Irreversible Thermodynamics of Membrane Processes 2.3 The Reflection Coefficient σ 2.4 The Relation between the Conventional and the Phenomenological Coefficients 2.5 The Physical Interpretation of the Phenomenological Coefficients 2.6 Methods of Measuring the Coefficients of Membrane Permeability 2.7 The Diffusion and Distribution of Ions 2.8 Active and Passive TransportChapter 3 The Molecular Basis of Diffusion across Cell Membranes 3.1 Introduction 3.2 Diffusion in Liquids as Movement within a Lattice 3.3 A Lattice Model for Diffusion into and across the Cell Membrane 3.4 Molecular Significance of the Parameters ∆F‡, ∆Η‡, ∆S‡, and PM1/2max 3.5 The Movement of Ions 3.6 An Alternative Model—Pores in the Cell Membrane 3.7 The Permeability of Water 3.8 ConclusionsChapter 4 Facilitated Diffusion—The Kinetic Analysis 4.1 Introduction 4.2 Criteria for Identifying Facilitated Diffusion Systems 4.3 Distribution of the Facilitated Diffusion Systems 4.4 A Preliminary Kinetic Analysis of Facilitated Diffusion 4.5 The Mobile Carrier Hypothesis 4.6 The Direct Determination of the Parameters Km and Vmax, Using the Flux Equations 4.7 The Dimerizer Hypothesis for Facilitated DiffusionChapter 5 The Coupling of Active Transport and Facilitated Diffusion 5.1 The Development of the View That Sodium Transport and Metabolite Transport Are Coupled 5.2 Experimental Tests of the Co-transport Model 5.3 The Kinetics of Co-transport 5.4 The Distribution Ratios at the Steady State 5.5 A Tertiary Active Transport SystemChapter 6 The Primary Active Transport Systems 6.1 Criteria for Distinguishing between Primary and Secondary Active Transport Systems 6.2 Indications That Certain Active Transport Systems May Not Be Linked to Other Driving Fluxes 6.3 The Linkage of Active Transport to Chemical Reactions 6.4 Kinetics of the Primary Transport Systems 6.5 Primary Active Transport Systems Uncoupled to the Energy Input 6.6 The Kinetics of "Pump" and "Leak" Systems 6.7 Ion Pumping by Epithelial Cell LayersChapter 7 The Movement of Water 7.1 The Volume of a Cell at the Steady State 7.2 Why a Linked Sodium/Potassium Pump 7.3 Transport across Epithelial Cell LayersChapter 8 Molecular Properties of the Transport Systems 8.1 Information Derived from Studies of the Specificity of Transport Systems 8.2 Molecular Significance of the Action of Drugs on Transport 8.3 Inhibition by Chemical Reagents 8.4 Attempts at the Isolation of Transport Systems from Cell Membranes 8.5 Data Suggesting That a Number of Transport Systems May Be Bivalent toward Substrates or InhibitorsChapter 9 Possible Mechanisms for Mediated Transfer 9.1 What the Models Have to Account For: A Summary of the Properties of the Mediated Transfer Systems 9.2 The Criteria of Acceptability for Model Systems of Transport 9.3 Models for Mediated Transfer 9.4 The Future of Transport StudiesReferencesAuthor IndexSubject Index