The Mouse in Biomedical Research

The Mouse in Biomedical Research


2nd Edition - December 5, 2006

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  • Editors: James Fox, Stephen Barthold, Muriel Davisson, Christian Newcomer, Fred Quimby, Abigail Smith
  • Hardcover ISBN: 9780123694584
  • eBook ISBN: 9780080469089

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Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.


Veterinary and medical students, graduate students, post-docs, immunologists, and researchers who utilize animals in biomedical research

Table of Contents

  • Volume IV Immunology

    1. The Molecular Basis of Lymphoid Architecture in the Mouse
    Carola G. Vinuesa and Matthew C. Cook

    2. The Biology of Toll-like Receptors in Mice
    Osamu Takeuchi and Shizuo Akira

    3. Genomic Organization of the Mouse Major Histocompatibility Complex
    Attila Kumánovics

    4. Some Biological Features of Dendritic Cells in the Mouse
    Kang Liu, Anna Charalambous and Ralph M. Steinman

    5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
    Recombination of Immunoglobulin Genes
    Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff

    6. Mouse Natural Killer Cells: Function and Activation
    Francesco Colucci

    7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
    Bin Liu and Ke Shuai

    8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
    Lakshmi R. Nagarajan and Yoji Shimizu

    9. Mouse Models of Negative Selection
    Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist

    10. Peripheral Tolerance of T Cells in the Mouse
    Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao

    11. The Genetics of Mouse Models of Systemic Lupus
    Srividya Subramanian and Edward K. Wakeland

    12. Inhibitory Receptors and Autoimmunity in the Mouse
    Menna R. Clatworthy and Kenneth G.C. Smith

    13. Mouse Models of Immunodeficiency
    B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert

    14. Mouse Models to Study the Pathogenesis of Allergic Asthma
    Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu

    15. The Mouse Trap: How Well Do Mice Model Human Immunology?
    Javier Mestas and Christopher C.W. Hughes

Product details

  • No. of pages: 392
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: December 5, 2006
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123694584
  • eBook ISBN: 9780080469089

About the Serial Volume Editors

James Fox

Prof. Fox obtained his Master of Science degree in Medical Microbiology at Stanford University and a Doctor in Veterinary Medicine at Colorado State University, Fort Collins. Dr. Fox is an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. In 2004 Professor Fox was elected to the Institute of Medicine of the National Academy of Sciences.

Affiliations and Expertise

Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA, USA

Stephen Barthold

Affiliations and Expertise

Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

Muriel Davisson

Affiliations and Expertise

The Jackson Laboratory, Bar Harbor, Maine

Christian Newcomer

Affiliations and Expertise

Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

Fred Quimby

Affiliations and Expertise

Laboratory Animal Research Center, The Rockefeller University, New York, NY

Abigail Smith

Affiliations and Expertise

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA

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