The Mouse in Biomedical Research
Immunology
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Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.
Readership
Veterinary and medical students, graduate students, post-docs, immunologists, and researchers who utilize animals in biomedical research
Table of Contents
- Volume IV Immunology
1. The Molecular Basis of Lymphoid Architecture in the Mouse
Carola G. Vinuesa and Matthew C. Cook
2. The Biology of Toll-like Receptors in Mice
Osamu Takeuchi and Shizuo Akira
3. Genomic Organization of the Mouse Major Histocompatibility Complex
Attila Kumánovics
4. Some Biological Features of Dendritic Cells in the Mouse
Kang Liu, Anna Charalambous and Ralph M. Steinman
5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff
6. Mouse Natural Killer Cells: Function and Activation
Francesco Colucci
7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
Bin Liu and Ke Shuai
8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
Lakshmi R. Nagarajan and Yoji Shimizu
9. Mouse Models of Negative Selection
Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist
10. Peripheral Tolerance of T Cells in the Mouse
Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao
11. The Genetics of Mouse Models of Systemic Lupus
Srividya Subramanian and Edward K. Wakeland
12. Inhibitory Receptors and Autoimmunity in the Mouse
Menna R. Clatworthy and Kenneth G.C. Smith
13. Mouse Models of Immunodeficiency
B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert
14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu
15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Javier Mestas and Christopher C.W. Hughes
Product details
- No. of pages: 392
- Language: English
- Copyright: © Academic Press 2006
- Published: December 5, 2006
- Imprint: Academic Press
- Hardcover ISBN: 9780123694584
- eBook ISBN: 9780080469089
About the Serial Volume Editors
James Fox
James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.
Affiliations and Expertise
Massachusetts Institute of Technology, Cambridge, MA, USA
Stephen Barthold
Affiliations and Expertise
Center for Comparative Medicine,
UC Davis School of Veterinary Medicine,
Davis CA
Muriel Davisson
Affiliations and Expertise
The Jackson Laboratory,
Bar Harbor, Maine
Christian Newcomer
Affiliations and Expertise
Research Animal Resources and Department of
Molecular and Comparative Pathobiology,
Johns Hopkins University,
Baltimore, MD
Fred Quimby
Affiliations and Expertise
Laboratory Animal Research Center,
The Rockefeller University,
New York, NY
Abigail Smith
Affiliations and Expertise
School of Veterinary Medicine,
University of Pennsylvania
Philadelphia, PA
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