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The Mouse in Biomedical Research - 2nd Edition - ISBN: 9780123694584, 9780080469089

The Mouse in Biomedical Research, Volume 4

2nd Edition


Serial Volume Editors: James Fox Stephen Barthold Muriel Davisson Christian Newcomer Fred Quimby Abigail Smith
Hardcover ISBN: 9780123694584
eBook ISBN: 9780080469089
Imprint: Academic Press
Published Date: 5th December 2006
Page Count: 392
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Table of Contents

Volume IV Immunology

  1. The Molecular Basis of Lymphoid Architecture in the Mouse Carola G. Vinuesa and Matthew C. Cook

  2. The Biology of Toll-like Receptors in Mice Osamu Takeuchi and Shizuo Akira

  3. Genomic Organization of the Mouse Major Histocompatibility Complex Attila Kumánovics

  4. Some Biological Features of Dendritic Cells in the Mouse Kang Liu, Anna Charalambous and Ralph M. Steinman

  5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
    Recombination of Immunoglobulin Genes Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff

  6. Mouse Natural Killer Cells: Function and Activation Francesco Colucci

  7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System Bin Liu and Ke Shuai

  8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse Lakshmi R. Nagarajan and Yoji Shimizu

  9. Mouse Models of Negative Selection Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist

  10. Peripheral Tolerance of T Cells in the Mouse Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao

  11. The Genetics of Mouse Models of Systemic Lupus Srividya Subramanian and Edward K. Wakeland

  12. Inhibitory Receptors and Autoimmunity in the Mouse Menna R. Clatworthy and Kenneth G.C. Smith

  13. Mouse Models of Immunodeficiency B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert

  14. Mouse Models to Study the Pathogenesis of Allergic Asthma Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu

  15. The Mouse Trap: How Well Do Mice Model Human Immunology? Javier Mestas and Christopher C.W. Hughes


Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.


Veterinary and medical students, graduate students, post-docs, immunologists, and researchers who utilize animals in biomedical research


No. of pages:
© Academic Press 2006
5th December 2006
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Serial Volume Editors

James Fox

James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, MA, USA

Stephen Barthold

Affiliations and Expertise

Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

Muriel Davisson

Affiliations and Expertise

The Jackson Laboratory, Bar Harbor, Maine

Christian Newcomer

Affiliations and Expertise

Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

Fred Quimby

Affiliations and Expertise

Laboratory Animal Research Center, The Rockefeller University, New York, NY

Abigail Smith

Affiliations and Expertise

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA