The Mouse in Biomedical Research

The Mouse in Biomedical Research

History, Wild Mice, and Genetics

2nd Edition - December 4, 2006

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  • Editors: James Fox, Stephen Barthold, Muriel Davisson, Christian Newcomer, Fred Quimby, Abigail Smith
  • eBook ISBN: 9780080469065
  • Hardcover ISBN: 9780123694553

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History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.


Researchers in laboratory medicine, genetics, immunology, infectious diseases and lab animals

Table of Contents

  • Volume I History, Genetics, and Wild Mice

    1. Building a Better Mouse: One Hundred Years of Genetics and Biology
    Herbert C. Morse III

    2. Systematics of the genus Mus
    Priscilla K. Tucker

    3. The Secret World of Wild Mice
    Grant R. Singleton and Charles J. Krebs

    4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types
    Melissa L. Berry and Carol Cutler Linder

    5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide
    Janan T. Eppig

    6. The Mouse Genome
    Mark D. Adams

    7. Gene Mapping
    Muriel T. Davisson

    8. Genetic Monitoring
    Richard R. Fox, Michael V. Wiles, and Petko M. Petkov

    9. Cytogenetics
    Muriel T. Davisson and Mary Ann Handel

    10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man
    M.H. Kaufman

    11. Gamete and Embryo Manipulation
    K.C. Kent Lloyd

    12. Chemical Mutagenesis in Mice
    Martin Hrabé de Angelis, Dian Michel, Sibylle Wagner, Sonja Becker and Johannes Beckers

    13. Gene-Specific Mutagenesis
    K.C. Kent Lloyd

    14. Gene Transfer Studies Using Mouse Models
    Robert G. Pergolizzi and Ronald G. Crystal

    15. Mouse and Human Pluripotent Stem Cells
    Leslie F. Lock

    16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics
    Lucia F. Jorge-Nebert, Sandrine Derkenne and Daniel W. Nebert

Product details

  • No. of pages: 344
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: December 4, 2006
  • Imprint: Academic Press
  • eBook ISBN: 9780080469065
  • Hardcover ISBN: 9780123694553

About the Serial Volume Editors

James Fox

Prof. Fox obtained his Master of Science degree in Medical Microbiology at Stanford University and a Doctor in Veterinary Medicine at Colorado State University, Fort Collins. Dr. Fox is an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. In 2004 Professor Fox was elected to the Institute of Medicine of the National Academy of Sciences.

Affiliations and Expertise

Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA, USA

Stephen Barthold

Affiliations and Expertise

Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

Muriel Davisson

Affiliations and Expertise

The Jackson Laboratory, Bar Harbor, Maine

Christian Newcomer

Affiliations and Expertise

Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

Fred Quimby

Affiliations and Expertise

Laboratory Animal Research Center, The Rockefeller University, New York, NY

Abigail Smith

Affiliations and Expertise

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA

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