The Mouse in Biomedical Research, Volume 1

Volume I History, Genetics, and Wild Mice

1. Building a Better Mouse: One Hundred Years of Genetics and Biology
Herbert C. Morse III

2. Systematics of the genus Mus
Priscilla K. Tucker

3. The Secret World of Wild Mice
Grant R. Singleton and Charles J. Krebs

4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types
Melissa L. Berry and Carol Cutler Linder

5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide
Janan T. Eppig

6. The Mouse Genome
Mark D. Adams

7. Gene Mapping
Muriel T. Davisson

8. Genetic Monitoring
Richard R. Fox, Michael V. Wiles, and Petko M. Petkov

9. Cytogenetics
Muriel T. Davisson and Mary Ann Handel

10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man
M.H. Kaufman

11. Gamete and Embryo Manipulation
K.C. Kent Lloyd

12. Chemical Mutagenesis in Mice
Martin Hrabé de Angelis, Dian Michel, Sibylle Wagner, Sonja Becker and Johannes Beckers

13. Gene-Specific Mutagenesis
K.C. Kent Lloyd

14. Gene Transfer Studies Using Mouse Models
Robert G. Pergolizzi and Ronald G. Crystal

15. Mouse and Human Pluripotent Stem Cells
Leslie F. Lock

16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics
Lucia F. Jorge-Nebert, Sandrine Derkenne and Daniel W. Nebert

History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.

Researchers in laboratory medicine, genetics, immunology, infectious diseases and lab animals