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The Mouse in Biomedical Research - 2nd Edition - ISBN: 9780123694553, 9780080469065

The Mouse in Biomedical Research, Volume 1

2nd Edition

History, Wild Mice, and Genetics

Serial Volume Editors: James Fox Stephen Barthold Muriel Davisson Christian Newcomer Fred Quimby Abigail Smith
eBook ISBN: 9780080469065
Hardcover ISBN: 9780123694553
Imprint: Academic Press
Published Date: 4th December 2006
Page Count: 344
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Table of Contents

Volume I History, Genetics, and Wild Mice

1. Building a Better Mouse: One Hundred Years of Genetics and Biology
Herbert C. Morse III

2. Systematics of the genus Mus
Priscilla K. Tucker

3. The Secret World of Wild Mice
Grant R. Singleton and Charles J. Krebs

4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types
Melissa L. Berry and Carol Cutler Linder

5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide
Janan T. Eppig

6. The Mouse Genome
Mark D. Adams

7. Gene Mapping
Muriel T. Davisson

8. Genetic Monitoring
Richard R. Fox, Michael V. Wiles, and Petko M. Petkov

9. Cytogenetics
Muriel T. Davisson and Mary Ann Handel

10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man
M.H. Kaufman

11. Gamete and Embryo Manipulation
K.C. Kent Lloyd

12. Chemical Mutagenesis in Mice
Martin Hrabé de Angelis, Dian Michel, Sibylle Wagner, Sonja Becker and Johannes Beckers

13. Gene-Specific Mutagenesis
K.C. Kent Lloyd

14. Gene Transfer Studies Using Mouse Models
Robert G. Pergolizzi and Ronald G. Crystal

15. Mouse and Human Pluripotent Stem Cells
Leslie F. Lock

16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics
Lucia F. Jorge-Nebert, Sandrine Derkenne and Daniel W. Nebert


History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.


Researchers in laboratory medicine, genetics, immunology, infectious diseases and lab animals


No. of pages:
© Academic Press 2006
4th December 2006
Academic Press
eBook ISBN:
Hardcover ISBN:

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About the Serial Volume Editors

James Fox

James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, MA, USA

Stephen Barthold

Affiliations and Expertise

Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

Muriel Davisson

Affiliations and Expertise

The Jackson Laboratory, Bar Harbor, Maine

Christian Newcomer

Affiliations and Expertise

Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

Fred Quimby

Affiliations and Expertise

Laboratory Animal Research Center, The Rockefeller University, New York, NY

Abigail Smith

Affiliations and Expertise

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA