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The Mouse in Biomedical Research - 2nd Edition - ISBN: 9780123694546, 9780080555287

The Mouse in Biomedical Research

2nd Edition

Serial Volume Editors: James Fox Stephen Barthold Muriel Davisson Christian Newcomer Fred Quimby Abigail Smith
Hardcover ISBN: 9780123694546
eBook ISBN: 9780080555287
Imprint: Academic Press
Published Date: 1st December 2006
Page Count: 2192


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In no other species of animal has such a wealth of experimental data been utilized for scientific pursuits. Now in its Second Edition, this Four Volume Set is dedicated to the understanding of the mouse and its role in scientific research. This valuable compendium serves as a standard reference source of information for students embarking on scientific careers, specialists in laboratory animal science, technicians in both animal care and research, and the broad scientific community.

This set is also sold individually and covers History, Wild Mice, and Genetics; Diseases; Normative Biology, Husbandry, and Models; and Immunology.

Volume 1: History, Wild Mice, and Genetics KEY FEATURES: • A primer for scientists new to the field of mouse research • Information about the history, biology and genomics of the laboratory mouse (Mus musculus) • Mouse origins and relationships covered in chapters on history, evolutionary taxonomy and wild mice • Mouse genetics and genomics discussed in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome • Use of the mouse as a model system for basic biomedical research described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation

Volume 2: Diseases KEY FEATURES: • New format by discussing specific disease causing microorganisms versus the format used in the first edition which discussed infectious diseases affecting specific organs and tissues • Consists of 26 chapters subdivided into RNA viruses and DNA viruses, mycotic, and parasitic infections. • Provides updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens • Offers information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter

Volume 3: Normative Biology, Husbandry, and Models KEY FEATURES: • Encompasses 23 chapters with a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. • Includes chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. • Discusses management, nutrition, gnotobiotics and disease surveillance • Provides analysis of the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases

Volume 4: Immunology KEY FEATURES: • A complete new addition to this series, dedicated to mouse immunology including both the innate and adaptive immune systems • Based on the mouse as a choice model when studying immunity in man-arguably more is known about the immune system in mice than any other species except man • Chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells

Key Features


  • Over 50% new material
  • Each volume contains 4-color page inserts with indispensable figures
  • Greatly expanded sections on genetics including: the mouse genome, gene mapping, and gene therapy
  • Information on newly recognized disease-causing organisms, such as mouse parvovirus and Helicobacter
  • A volume entirely devoted to mouse immunology
  • New section on stem cell biology
  • Each of the four volumes are available individually


Veterinary and medical students, senior graduate, graduate students, post-docs, and researchers who utilize animals in biomedical research

Table of Contents

Volume I History, Wild Mice, and Genetics

  1. Building a Better Mouse: One Hundred Years of Genetics and Biology Herbert C. Morse III

  2. Systematics of the genus Mus Priscilla K. Tucker

  3. The Secret World of Wild Mice Grant R. Singleton and Charles J. Krebs

  4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types Melissa L. Berry and Carol Cutler Linder

  5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide Janan T. Eppig

  6. The Mouse Genome Mark D. Adams

  7. Gene Mapping Muriel T. Davisson

  8. Genetic Monitoring Richard R. Fox, Michael V. Wiles, and Petko M. Petkov

  9. Cytogenetics Muriel T. Davisson and Mary Ann Handel

  10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man M.H. Kaufman

  11. Gamete and Embryo Manipulation K.C. Kent Lloyd

  12. Chemical Mutagenesis in Mice Martin Hrabé de Angelis, Dian Michel, Sibylle Wagner, Sonja Becker and Johannes Beckers

  13. Gene-Specific Mutagenesis
    K.C. Kent Lloyd

  14. Gene Transfer Studies Using Mouse Models Robert G. Pergolizzi and Ronald G. Crystal

  15. Mouse and Human Pluripotent Stem Cells Leslie F. Lock

  16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics Lucia F. Jorge-Nebert, Sandrine Derkenne and Daniel W. Nebert

Volume II Diseases

Viral Diseases

DNA Viruses

  1. Mouse Cytomegalovirus and other Herpesviruses Geoffrey R. Shellam, Alec J. Redwood, Lee M. Smith and Shelley Gorman

  2. Mouse Adenoviruses Katherine R. Spindler, Martin L. Moore, Angela N. Cauthen

  3. Mousepox R. Mark L. Buller and Frank Fenner

  4. Parvoviruses Robert O. Jacoby and Lisa Ball-Goodrich

  5. Polyoma Viruses Thomas L. Benjamin

RNA Viruses

  1. Mouse Hepatitis Virus Stephen W. Barthold and Abigail L. Smith

  2. Lymphocytic Choriomeningitis Virus Stephen W. Barthold and Abigail L. Smith

  3. Lactate Dehydrogenase-Elevating Virus Jean-Paul Coutelier and Margo A. Brinton

  4. Reoviridae Richard L. Ward, Monica M. McNeal, Mary B. Faron and Anthony L. Farone

  5. Retroelements in the Mouse Herbert C. Morse III

  6. Sendai Virus and Pneumonia Virus of Mice (PVM) David G. Brownstein

  7. Cardioviruses: Encephalomyocarditis Virus and Theiler's Mouse Encephalomyelitis Virus Howard L. Lipton, A.S. Manoj Kumar, and Shannon Hertzler

Bacterial Diseases

  1. Chlamydial Diseases Robert G. Rank

  2. Clostridial Species Kimberly S. Waggie

  3. Enterobacteriaceae, Pseudomonas aeruginosa, and Streptobacillus moniliformis Hilda Holcombe and David B. Schauer

  4. Aerobic Gram-positive Organisms Cynthia Besch-Williford and Craig L. Franklin

  5. Helicobacter Infections in Mice James G. Fox and Mark T. Whary

  6. Mycoplasma pulmonis, Other Mouse Mycoplasmas, and Cilia-Associated Respiratory Bacillus Trenton R. Schoeb

  7. Pasteurellaceae Werner Nicklas

Mycotic and Parasitic Diseases

  1. Fungal Diseases in Laboratory Mice Virginia L. Godfrey

  2. Protozoa Katherine Wasson

  3. Helminth Parasites of Laboratory Mice Kathleen R. Pritchett

  4. Anthropods David G. Baker

Miscellaneous Diseases

  1. The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathology Robert D. Cardiff, Robert J. Munn, and Jose J. Galvez

  2. Spontaneous Diseases in Commonly Used Mouse Strains Cory Brayton

  3. Zoonoses and Other Human Health Hazards Christian E. Newcomer and James G. Fox

Volume III Normative Biology, Husbandry, and Models

Normative Biology

  1. Gross Anatomy Vladimír Komárek

  2. Mouse Physiology Robert F. Hoyt, Jr., James V. Hawkins, Mark B. St Claire and Mary B. Kennett

  3. Reproductive Biology of the Laboratory Mouse Kate Pritchett and Robert Taft

  4. Endocrinology: Bone as a target tissue for hormonal regulation Krista M. Delahunty and Wesley G. Beamer

  5. Hematology of the Laboratory Mouse Nancy E. Everds

  6. Clinical Chemistry of the Laboratory Mouse Fred W. Quimby and Richard H. Luong

Management, Techniques, and Husbandry

  1. Gnotobiotics Richard J. Rahija

  2. Management and Design: Breeding Facilities William J. White

  3. Design and Management of Research Facilities for Mice Neil S. Lipman

  4. Nutrition Graham Tobin, Karla A. Stevens and Robert J. Russell

  5. Health Delivery and Quality Assurance Programs for Mice

    <EM>Diane J. Gaertner, Glen Otto and Margaret Batchelder</EM>
  6. Environmental and Equipment Monitoring J. David Small and Rick Deitrich

  7. Biomethodology and Surgical Techniques

    <EM>Alison M. Hayward, Laura B. Lemke, Erin C. Bridgeford, Elizabeth J. Theve, Courtnye N. Jackson, Terrie L. Cunliffe-Beamer, Robert P. Marini</EM>
  8. In Vivo Whole-Body Imaging of the Laboratory Mouse Simon R. Cherry

Use of Mice in Biomedical Research

  1. Behavioral Testing Douglas Wahlsten and John C. Crabbe

  2. Cardiovascular Disease: Mouse Models of Atherosclerosis Nobuyo Maeda, Raymond C. Givens and Robert L. Reddick

  3. Convulsive Disorders Mariana T. Todorova and Thomas N. Seyfried

  4. Eye Research Richard S. Smith, Patsy M. Nishina, John P. Sundberg, Johann Zwaan, and Simon W.M. John

  5. Genetic Analysis of Rodent Obesity and Diabetes Sally Chiu, Janis S. Fisler, and Craig H. Warden

  6. Mouse Models in Aging Research Kevin Flurkey, Joanne M. Currer, and D.E. Harrison

  7. Mouse Models of Inherited Human Neurodegenerative Disease Karl Herrup

  8. Mouse Skin Ectodermal Organs Maksim V. Plikus, John P. Sundberg, and Cheng-Ming Chuong

  9. Quality Control Testing of Biologicals William R. Shek

Volume IV Immunology

Molecular and Cellular Immunology of the Mouse: An Overview Fred W. Quimby and David D. Chaplin

  1. The Molecular Basis of Lymphoid Architecture in the Mouse Carola G. Vinuesa and Matthew C. Cook

  2. The Biology of Toll-like Receptors in Mice Osamu Takeuchi and Shizuo Akira

  3. Genomic Organization of the Mouse Major Histocompatibility Complex Attila Kumánovics

  4. Some Biological Features of Dendritic Cells in the Mouse Kang Liu, Anna Charalambous and Ralph M. Steinman

  5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
    Recombination of Immunoglobulin Genes Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff

  6. Mouse Natural Killer Cells: Function and Activation Francesco Colucci

  7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System Bin Liu and Ke Shuai

  8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse Lakshmi R. Nagarajan and Yoji Shimizu

  9. Mouse Models of Negative Selection Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist

  10. Peripheral Tolerance of T Cells in the Mouse Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao

  11. The Genetics of Mouse Models of Systemic Lupus Srividya Subramanian and Edward K. Wakeland

  12. Inhibitory Receptors and Autoimmunity in the Mouse Menna R. Clatworthy and Kenneth G.C. Smith

  13. Mouse Models of Immunodeficiency B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert

  14. Mouse Models to Study the Pathogenesis of Allergic Asthma Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu

  15. The Mouse Trap: How Well Do Mice Model Human Immunology? Javier Mestas and Christopher C.W. Hughes


No. of pages:
© Academic Press 2007
1st December 2006
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Serial Volume Editors

James Fox

James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, MA, USA

Stephen Barthold

Affiliations and Expertise

Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

Muriel Davisson

Affiliations and Expertise

The Jackson Laboratory, Bar Harbor, Maine

Christian Newcomer

Affiliations and Expertise

Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

Fred Quimby

Affiliations and Expertise

Laboratory Animal Research Center, The Rockefeller University, New York, NY

Abigail Smith

Affiliations and Expertise

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA