The Mouse in Biomedical Research

The Mouse in Biomedical Research

History, Genetics, and Wild Mice

1st Edition - January 1, 1981

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  • Editor: Henry Foster
  • eBook ISBN: 9780323156066

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The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.

Table of Contents

  • List of Contributors



    List of Reviewers for Chapters in this Volume

    Chapter 1 The Laboratory Mouse - A Historical Perspective



    Chapter 2 Taxonomy

    I. Objective

    II. Problems Concerning Evolution within the Genus Mus

    II. Survey of the Genus Mus (Rodentia: Muridae)

    IV.Key to Species of House Mice


    Chapter 3 Nomenclature

    I. Introduction

    II. Rules and Guidelines for Gene Nomenclature

    III. Rules for Designation of Chromosome Anomalies

    IV. Rules for Nomenclature of Inbred Strains

    V. Sources of Information on Specialized Nomenclature


    Chapter 4 Wild Mice

    I. Introduction

    II. Natural History


    IV. Physiology

    V. Behavior

    VI. Reproduction: Intensity and Regulation

    VII. Demography

    VIII. Population Dynamics

    IX. Field Techniques and Captive Propagation


    Note Added in Proof

    Chapter 5 Breeding Systems

    I. Breeding Systems and Products

    II. Definitions and Symbols

    III. Random-Bred Stocks

    IV. Inbred Strains

    V. F1 Hybrids

    VI. Recombinant Inbred Strains

    VII. Congenic and Coisogenic Inbred Strains

    VIII. Segregating Inbred Strains

    IX. Comparison of Systems: Sequential Use of Back-crossing and Inbreeding

    X. Strategies and Experimental Designs

    XI. Survey of the Literature


    Chapter 6 Gene Mapping

    I. Introduction

    II. Linkage Map on the Mouse

    III. Detection and Measurement of Linkage

    IV. Methods for Assigning Loci to Chromosomes or to Chromosome Regions

    V. Usefulness of Linkage Information


    Chapter 7 The Histocompatibility-2 (H-2) Complex

    I. Histocompatibility

    II. Minor Histocompatibility Loci

    III. Major Histocompatibility Loci

    IV. Genetic Organization of the H-2 Complex

    V. Class I Loci

    VI. Class II Loci

    VII. Class III Loci

    VIII. Class IV Loci

    IX. The Elusive Hybrid Resistance Genes

    X. H-2 Linked Isozyme Loci

    XI. Conclusion


    Chapter 8 Genetic Monitoring

    I. Introduction

    II. The Origin of Genetic Drift in Mouse Populations

    III. Genetic Control Measures Suitable for Monitoring Schemes

    IV. Routine Application of Control Measures


    Chapter 9 Inbred and Segregating Inbred Strains

    I. Introduction

    II. Abbreviations Used in List of Strains

    III. Inbred Strains

    IV. Recommended Abbreviations for Widely Used Strains

    V. Abbreviations for Use in Symbolizing Substrates of Mice and Rats and for Designating Holders of Strains


    Chapter 10 Congenic Strains

    I. Introduction

    II. Production of a Congenic Strain

    III. Specialized Types of Congenic Strains

    IV. Perspective


    Chapter 11 Recombinant Inbred Strains and Bilineal Congenic Strains

    I. Introduction

    II. Recombinant Inbred Strains

    III. Bilineal Congenic Strains


    Chapter 12 Cytogenetics

    I. Methods for Studying Mitotic Chromosomes

    II. Applications of Study of Mitotic Chromosomes

    III. Meiotic Chromosome Studies


    Chapter 13. Radiation Genetics

    I. Introduction

    II. Types of Mutations and Ways of Measuring Their Frequencies of Induction

    III. Gametogenesis

    IV. Effects of Considerable Importance in Estimating Genetic Risk for Humans That Were Discovered Using the Specific-Locus Method

    V. Analysis of Genetic Nature of Specific-Locus Mutations

    VI. Recessive Lethal Mutations

    VII. Dominant Visible Mutations

    VIII. Dominant Lethal Mutations

    IX. Dominant Skeletal Mutations

    X. Other Approaches Used in Studying Induction of Gene Mutations

    XI. Gross Changes in Chromosome Structure or Number

    XII. Effects of Other Types of Radiation

    XIII. Effects on Populations

    XIV. Use of Data Collected in Mice in Making Risk Estimates


    Chapter 14. Selected Aspects of Pharmacogenetics

    I. Introduction

    II. Genetically Determined Differences in Xenobiotic Metabolism

    III. Well-Defined Pharmacogenetic Polymorphisms

    IV. Suggested Future Areas of Research in Mouse Pharmacogenetics


    Addendum: The Histocompatibility-2 {H-2) Complex


Product details

  • No. of pages: 320
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: January 1, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9780323156066

About the Editor

Henry Foster

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