The Molecular Properties and Evolution of Excitable Cells describes the theoretical aspects in which excitable cells, such as nerves, muscles, and sense organs, operate. This book develops a hypothesis regarding the evolution and characteristics of excitable cells. This monograph focuses on the properties of the bounding membrane and its complex permeability system, which starts the excitation state. Sense organs, as the input component in both vertebrates and invertebrates, are then discussed.
The text then briefly describes the ways that the ionic permeability of the excitable membrane can both be modified and controlled. The book points out that since ions pass through standard sizes of the pores in an excitable membrane, their passage is determined by the dimensions of the pore and by the existing charge found on its walls. The book then explains the application of a mechanical stimulus to a mechanoreceptor that will cause deformations in the membrane. This deformation leads to enzyme activity and produces alteration in the rate at which ATP is supplied to the lateral borders of the cell. The text discusses a hypothesis that invokes enzyme activity by propagating action potential along the axon, and other input systems, such as adrenaline, amino acids, and y-amino-butyric acid (GABA). The book also explains the hypothesis that living organisms are composed of an ordered system of protein-enzymes forming on phospholipid-protein membranes.
This monograph will benefit microbiologists, biotechnologists, and academicians connected with the biological sciences.
Preface Chapter 1. Introduction1. The Organization of Excitable Cells
Chapter 2. A Model for Excitable Cells Summary Chapter 3. The Input Component: Sense Organs1. Mechanoreceptors 2. Evidence for the Enzymatic Transducer Mechanism of Sense Organs 3. Enzyme Systems Involved at Sense Organs Summary
Chapter 4. The Control of Cation-Permeability at Input Components1. Properties of Membrane ATPases 2. Mechanoenzyme System of the Mitochondrial Membrane 3. Selective Permeability Systems 4. Hypothesis for the Control of Membrane Permeability 5. The Action of Thyroxine Summary
Chapter 5. The Transducer Mechanisms of Specialized Sensory Receptors1. Chemoreceptors 2. Thermoreceptors 3. Visual Receptors Summary
Chapter 6. The Input Component: the Postsynaptic Membrane1. Transmission at Cholinergic Synapses 2. Evidence for the Enzymatic Transducer Mechanism of the Post-Synaptic Membrane 3. Tetanus Toxin and the Neurotropic Agent of Snake Venom Summary
Chapter 7. Cholinesterases1. Acetylcholine Sensitivity 2. Properties and Distribution of Cholinesterases 3. Action of Cholinesterase Inhibitors 4. Cholinesterase and the Permeability System 5. The Transducer Mechanism at Cholinergic Membranes Summary
Chapter 8. Other Input Systems1. Adrenaline 2. Aminoacids 3. γ-Amino-Butyric Acid (GABA) 4. Inhibitory Synapses Summary
Chapter 9. Comparison between the Input and Conductile Components Summary Chapter 10. Sodium Permeability and the Excitation of the Conductile Axon1. Properties of the Cation-Permeability System of the Axon 2. Excitation of the Axon 3. The Erythrocyte as a Model for the Excitable Membrane Summary
Chapter 11. The Output Component: Release of Synaptic Transmitters1. Miniature Endplate Potentials 2. Relation between Spontaneou
- No. of pages:
- © Pergamon 1967
- 1st January 1967
- eBook ISBN:
University of Southampton, Southampton, UK