The Molecular Biology of Neurological Disease

The Molecular Biology of Neurological Disease

Butterworths International Medical Reviews

1st Edition - March 11, 1988

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  • Editors: Roger N. Rosenberg, A. E. Harding
  • eBook ISBN: 9781483163307

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The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Table of Contents

  • 1 Molecular Genetics and Neurological Disease: Basic Principles and Methods

    2 Genes Expressed in the Brain: Evolutionary and Developmental Considerations

    3 In Situ Hybridization: Visualizing Brain Messenger RNA

    4 Molecular Biology of Chemical Neurotransmission

    5 Proteins which Regulate the Development of the Nervous System

    6 Gene Expression in Skeletal Muscle

    7 Host and Viral Genetic Factors which Influence Viral Neurotropism

    8 Neuro-Oncogenesis: Recessive Genes, Activated Oncogenes, and Chromosome Abnormalities in the Development of Neuro-Ectodermal Cancers

    9 Transgenic Mice and Neurological Disease

    10 Messenger RNA Levels in Neurological Disease

    11 Molecular Genetics of Joseph Disease

    12 Huntington's Disease

    13 Molecular Genetics and Muscular Dystrophy

    14 Mitochondrial Genes and Neurological Disease

    15 Molecular Basis of Retinoblastoma

    16 Detection of Viral Genes in Neurological Disease

    17 Immunogenetics: Genetic Polymorphism and Susceptibility to Neurological Disease

    18 A Neurological Gene Map


Product details

  • No. of pages: 276
  • Language: English
  • Copyright: © Butterworth-Heinemann 1988
  • Published: March 11, 1988
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483163307

About the Editors

Roger N. Rosenberg

A. E. Harding

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