The Molecular Biology of Neurological Disease - 1st Edition - ISBN: 9780407024007, 9781483163307

The Molecular Biology of Neurological Disease

1st Edition

Butterworths International Medical Reviews

Editors: Roger N. Rosenberg A. E. Harding
eBook ISBN: 9781483163307
Imprint: Butterworth-Heinemann
Published Date: 11th March 1988
Page Count: 276
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Description

The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Table of Contents


1 Molecular Genetics and Neurological Disease: Basic Principles and Methods

2 Genes Expressed in the Brain: Evolutionary and Developmental Considerations

3 In Situ Hybridization: Visualizing Brain Messenger RNA

4 Molecular Biology of Chemical Neurotransmission

5 Proteins which Regulate the Development of the Nervous System

6 Gene Expression in Skeletal Muscle

7 Host and Viral Genetic Factors which Influence Viral Neurotropism

8 Neuro-Oncogenesis: Recessive Genes, Activated Oncogenes, and Chromosome Abnormalities in the Development of Neuro-Ectodermal Cancers

9 Transgenic Mice and Neurological Disease

10 Messenger RNA Levels in Neurological Disease

11 Molecular Genetics of Joseph Disease

12 Huntington's Disease

13 Molecular Genetics and Muscular Dystrophy

14 Mitochondrial Genes and Neurological Disease

15 Molecular Basis of Retinoblastoma

16 Detection of Viral Genes in Neurological Disease

17 Immunogenetics: Genetic Polymorphism and Susceptibility to Neurological Disease

18 A Neurological Gene Map

Index

Details

No. of pages:
276
Language:
English
Copyright:
© Butterworth-Heinemann 1988
Published:
Imprint:
Butterworth-Heinemann
eBook ISBN:
9781483163307

About the Editor

Roger N. Rosenberg

A. E. Harding

Ratings and Reviews