The Molecular Biology of Cadherins

The Molecular Biology of Cadherins

1st Edition - March 8, 2013

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  • Editor: Frans Van Roy
  • Hardcover ISBN: 9780123943118
  • eBook ISBN: 9780123946478

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Description

This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers and molecular biologists

Table of Contents

  • Contributors

    Preface

    Chapter One. Roles of Cadherins and Catenins in Cell−Cell Adhesion and Epithelial Cell Polarity

    Abstract

    1 Introduction: The Basic Design of Polarized Epithelial Cells

    2 Cadherin-Mediated Cell–Cell Adhesion and the Function of Polarity Proteins in Apical–Basal Cell Polarity

    3 Other Functions of E-Cadherin, Catenins, and “Polarity Protein” Complexes in Maintaining Epithelial Homeostasis

    4 Cadherin, Catenins, and the Origins of Epithelial Polarity

    Acknowledgments

    References

    Chapter Two. Stability and Dynamics of Cell–Cell Junctions

    Abstract

    1 Introduction

    2 Stability of AJs

    3 Dynamics of AJs Mediated by Actin Turnover

    4 Mechanical Regulation of AJs

    5 Dynamics of AJs During Development

    6 Conclusions

    Acknowledgments

    References

    Chapter Three. Coordinating Rho and Rac: The Regulation of Rho GTPase Signaling and Cadherin Junctions

    Abstract

    1 Introduction

    2 Some Things to Consider About Rho GTPases

    3 Regulation of Rho GTPase Signaling by Classical Cadherins

    4 Functions of Rho and Rac in Cadherin Cell–Cell Interactions

    5 Concluding Remarks

    Acknowledgments

    References

    Chapter Four. New Insights into the Evolution of Metazoan Cadherins and Catenins

    Abstract

    1 Cadherins in Multicellular Animals

    2 Catenins with Armadillo Domains

    3 Alpha-Catenins in Metazoans

    4 Cadherins and Catenins in Non-Metazoans

    Acknowledgments

    References

    Chapter Five. Structure, Function, and Regulation of Desmosomes

    Abstract

    1 Desmosome Composition and Architecture

    2 Making and Breaking Desmosomes: Regulation of Adhesive Strength

    3 Desmosomes in Disease

    4 Desmosomal Proteins in Differentiation, Development, and Cancer

    5 Future Directions

    Acknowledgments

    References

    Chapter Six. The Role of VE-Cadherin in Vascular Morphogenesis and Permeability Control

    Abstract

    1 Introduction

    2 Structural Properties of VE-Cadherin

    3 VE-Cadherin Partners and Intracellular Signaling

    4 VE-Cadherin and N-Cadherin Cross Talk

    5 VE-Cadherin in Leukocyte Transmigration and Vascular Permeability

    6 Conclusions

    Acknowledgments

    References

    Chapter Seven. Clustered Protocadherins and Neuronal Diversity

    Abstract

    1 Introduction

    2 Clustered Pcdhs

    3 Stochastic and Combinatorial Gene Expressions Generate Molecular Diversity in Individual Neurons

    4 Gene Regulation of Clustered Pcdhs is Associated with Epigenetic Modifications

    5 Spatial and Temporal Expression and Localization of Clustered Pcdhs

    6 Intracellular Signaling by Clustered Pcdhs and Protein Dynamics

    7 Heteromultimeric Protein Complexes of Clustered Pcdhs Generate Molecular Diversity at the Protein Level

    8 In Vivo Functions of Clustered Pcdhs

    9 Conclusions

    References

    Chapter Eight. Delta-Protocadherins in Health and Disease

    Abstract

    1 Identification of δ-Protocadherin Family Members

    2 Structural Properties of δ-Protocadherins

    3 Physiological and Developmental Functions of δ-Protocadherins

    4 Aberrations in Human Diseases

    5 Conclusions

    Acknowledgments

    References

    Chapter Nine. Atypical Cadherins Celsr1–3 and Planar Cell Polarity in Vertebrates

    Abstract

    1 Introduction to Celsr Proteins and PCP

    2 Celsr1–3 Expression Patterns

    3 Celsr1: A Major Player in Vertebrate PCP

    4 Celsr2 and -3 in Ciliogenesis

    5 Celsr1–3 in Neuronal Migration

    6 Celsr2 and Celsr3 in Brain Wiring

    7 Structure–Function Data on Celsr

    References

    Chapter Ten. Fat and Dachsous Cadherins

    Abstract

    1 Introduction

    2 Fat–Dachsous and PCP

    3 Fat–Dachsous, Growth Control, and the Hippo Pathway

    4 Other Members of the Ft–Ds Pathway: Dachs, Atrophin, and Lowfat

    5 Ft–Ds Signaling and Vertebrate Development

    6 Summary

    References

    Chapter Eleven. Cadherins and Their Partners in the Nematode Worm Caenorhabditis elegans

    Abstract

    1 Caenorhabditis elegans: A Model for Studying Cadherin Function In Vivo

    2 The Classical Cadherin/Catenin Complex in C. elegans

    3 Regulating the Classical CCC in C. elegans

    4 New Functional Partners with the Classical CCC in C. elegans

    5 Beyond the Classical CCC: Other Cadherin Family Members in C. elegans

    6 Conclusions

    Acknowledgments

    References

    Chapter Twelve. N-Cadherin-Mediated Adhesion and Signaling from Development to Disease: Lessons from Mice

    Abstract

    1 Introduction

    2 N-Cadherin Function in Cardiovascular Development and Disease

    3 Cooperation Between the Mesenchymal Cadherins, N-Cadherin and Cadherin-11

    4 N-Cadherin-Mediated Signaling in Cancer

    5 Functional Overlap and Distinct Functions for N- and E-Cadherin

    6 Cooperation Between N-Cadherin and Integrins

    7 Conclusions/Future Directions

    Acknowledgments

    References

    Chapter Thirteen. Cadherin Dynamics During Neural Crest Cell Ontogeny

    Abstract

    1 An Introduction to the Neural Crest

    2 Cadherins in Premigratory Neural Crest Cells and their EMT

    3 Cadherins in Neural Crest Migration

    4 Cadherins in Neural Crest Differentiation

    5 Conclusions

    References

    Chapter Fourteen. Cadherins and Epithelial-to-Mesenchymal Transition

    Abstract

    1 Introduction

    2 EMT and the Modulation of Cadherins During Development

    3 Transcriptional Modulation of E-Cadherin Contributes to Malignant Carcinoma Progression

    4 Concluding Remarks

    References

    Chapter Fifteen. E-Cadherin Alterations in Hereditary Disorders with Emphasis on Hereditary Diffuse Gastric Cancer

    Abstract

    1 General Introduction

    2 E-Cadherin Alteration in Hereditary Disorders

    3 Molecular Pathology in CDH1 Germline Mutation Carriers

    4 Animal and Cell Culture Models for Studying CDH1-Associated Diseases

    References

    Chapter Sixteen. Cadherin Defects in Inherited Human Diseases

    Abstract

    1 Introduction

    2 Classical Type-I and Desmosomal Cadherins in the Skin, Hair Follicles, and Heart

    3 Cadherins in the Central Nervous System

    4 The Ear and the Eye: Two Sensory Organs Under Mechanical Constraints

    5 Concluding Remarks

    Acknowledgments

    References

    Chapter Seventeen. Beta-Catenin Versus the Other Armadillo Catenins: Assessing Our Current View of Canonical Wnt Signaling

    Abstract

    1 Overview of Catenins

    2 Cadherin–Catenin Complexes

    3 The “Canonical” View of Canonical Wnt Signaling

    4 The “Other” Catenins in the Nucleus

    5 Isoform Diversity in the “Other” Catenins

    6 Wnt Signaling and “the Other” Catenins

    7 Canonical Wnt Signaling in the Context of Catenin–Small-GTPase Effects

    8 Redefining “Canonical” Wnt Signaling

    9 Conclusion and Gaps in Knowledge

    Acknowledgments

    References

    Chapter Eighteen. p120 Catenin: An Essential Regulator of Cadherin Stability, Adhesion-Induced Signaling, and Cancer Progression

    Abstract

    1 Introduction: History of p120

    2 Structure

    3 Function

    4 p120 in Cancer

    References

    Chapter Nineteen. Afadin/AF-6 and Canoe: Roles in Cell Adhesion and Beyond

    Abstract

    1 Introduction

    2 General Properties of Afadin/AF-6 and Cno

    3 Functions of Afadin/AF-6 in Mammals

    4 Afadin/AF-6 in Leukemogenesis and Oncogenesis

    5 Functions of Cno in Fly

    6 Perspectives

    References

    Index

Product details

  • No. of pages: 488
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: March 8, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123943118
  • eBook ISBN: 9780123946478

About the Serial Volume Editor

Frans Van Roy

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