Description

This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Researchers and molecular biologists

Table of Contents

Contributors

Preface

Chapter One. Roles of Cadherins and Catenins in Cell−Cell Adhesion and Epithelial Cell Polarity

Abstract

1 Introduction: The Basic Design of Polarized Epithelial Cells

2 Cadherin-Mediated Cell–Cell Adhesion and the Function of Polarity Proteins in Apical–Basal Cell Polarity

3 Other Functions of E-Cadherin, Catenins, and “Polarity Protein” Complexes in Maintaining Epithelial Homeostasis

4 Cadherin, Catenins, and the Origins of Epithelial Polarity

Acknowledgments

References

Chapter Two. Stability and Dynamics of Cell–Cell Junctions

Abstract

1 Introduction

2 Stability of AJs

3 Dynamics of AJs Mediated by Actin Turnover

4 Mechanical Regulation of AJs

5 Dynamics of AJs During Development

6 Conclusions

Acknowledgments

References

Chapter Three. Coordinating Rho and Rac: The Regulation of Rho GTPase Signaling and Cadherin Junctions

Abstract

1 Introduction

2 Some Things to Consider About Rho GTPases

3 Regulation of Rho GTPase Signaling by Classical Cadherins

4 Functions of Rho and Rac in Cadherin Cell–Cell Interactions

5 Concluding Remarks

Acknowledgments

References

Chapter Four. New Insights into the Evolution of Metazoan Cadherins and Catenins

Abstract

1 Cadherins in Multicellular Animals

2 Catenins with Armadillo Domains

3 Alpha-Catenins in Metazoans

4 Cadherins and Catenins in Non-Metazoans

Acknowledgments

References

Chapter Five. Structure, Function, and Regulation of Desmosomes

Abstract

1 Desmosome Composition and Architecture

2 Making and Breaking Desmosomes: Regulation of Adhesive Strength

3 Desmosomes in Disease

4 Desmosomal Proteins in Differentiation, Development, and C

Details

No. of pages:
488
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780123943118
Electronic ISBN:
9780123946478

Reviews

Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal