The Molecular Biology of Arrestins

The Molecular Biology of Arrestins

1st Edition - June 10, 2013

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  • Editor: Louis M. Luttrell
  • Hardcover ISBN: 9780123944405
  • eBook ISBN: 9780123947895

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Description

This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Readership

Students, researchers, microbiologists, molecular biologists

Table of Contents

  • Contributors

    Preface

    Part I: Perspective - The Duality of Arrestin Function

    Chapter One. Arrestins Come of Age: A Personal Historical Perspective

    1 Introduction

    2 “Prehistory” of Arrestins

    3 A Family of 7 Transmembrane Receptors

    4 The GRK and Arrestin Families

    5 Arrestins and Desensitization

    6 Arrestins and Endocytosis

    7 Arrestins and Signaling

    8 Biased Signaling

    9 Bar Code Hypothesis

    10 Other Receptors, Other Functions

    11 Future Perspectives

    References

    Part II: The Molecular Biology of Arrestins

    Chapter Two. True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal

    Abbreviations

    1 Introduction

    2 True Arrestins: A Structure Adapted to Multiple Scaffolding

    3 Novel Arrestin-Related Proteins

    4 Other Arrestin-Fold Proteins

    5 Are Arrestins and Arrestin-Fold Proteins Related by a Shared Mechanism for Their Function?

    6 Conclusion and Perspectives

    References

    Chapter Three. Structural Determinants of Arrestin Functions

    1 Introduction

    2 What the Crystal Structure Reveals, and What It Does Not

    3 How Do Arrestins Fit Receptors?

    4 Interactions with Other Signaling Proteins

    5 Designing Signaling-Biased Arrestin Mutants

    6 Conclusions: Where Do We Go from Here?

    Acknowledgments

    References

    Chapter Four. Arrestins: Role in the Desensitization, Sequestration, and Vesicular Trafficking of G Protein-Coupled Receptors

    1 Introduction

    2 Arrestins in GPCR Desensitization

    3 Arrestins in GPCR Trafficking

    4 Conclusions

    Acknowledgments

    References

    Chapter Five. Arrestins as Regulators of Kinases and Phosphatases

    1 Introduction

    2 Arrestins as GPCR Effectors

    3 Positive and Negative Regulation of Kinase Pathways

    4 Arrestin-Regulated Kinase and Phosphatase Pathways

    5 Conclusions

    Acknowledgments

    References

    Chapter Six. β-Arrestins: Modulators of Small GTPase Activation and Function

    1 Introduction

    2 Ras Family GTPases

    3 Rho Family GTPases

    4 Rab Family GTPases

    5 ARF Family GTPases

    6 Ran Family GTPases

    7 Perspectives and Future Directions

    8 Conclusions

    References

    Chapter Seven. Arrestins and Protein Ubiquitination

    1 Introduction

    2 Ubiquitination of Arrestins

    3 Deubiquitination of Arrestins

    4 Arrestins Act as Adaptors for Ubiquitination

    5 Arrestins and Seven-Transmembrane Receptor Deubiquitination

    6 Arrestin-Like Proteins

    7 Conclusions

    Acknowledgment

    References

    Chapter Eight. Arrestins in Actin Reorganization and Cell Migration

    1 Introduction

    2 β-Arrestins as Regulators of Gradient Sensing for Chemokine Receptors

    3 β-Arrestins as Regulators of Actin Assembly

    4 Regulation of Kinase Activities by β-Arrestins

    5 Additional Roles for β-Arrestins and Chemotaxis In Vivo

    6 Role of β-Arrestin-Dependent Chemotaxis in Health and Disease

    7 Concluding Remarks

    References

    Part III: The Physiological Roles of Arrestins

    Chapter Nine. The Role of Arrestins in Development

    1 Introduction

    2 β-Arrestins in Model Organisms

    3 The Function of Arrestins in Invertebrates

    4 β-Arrestins in Vertebrate Development

    5 Conclusions

    Acknowledgments

    References

    Chapter Ten. The Role of Arrestins in Visual and Disease Processes of the Eye

    1 Visual Arrestin Nomenclature

    2 The Function of Visual Arrestins in Quenching Phototransduction

    3 Splice Variants of Arrestin1

    4 Arrestins in Cone Photoreceptors

    5 Translocation of Visual Arrestins

    6 New Roles for Arrestin1 in the Retina

    7 Arrestins in Disease Processes in the Eye

    8 The Future for Visual Arrestins

    References

    Chapter Eleven. β-Arrestins in the Central Nervous System

    1 Introduction: Arrestins and GRK in the Central Nervous System

    2 Arrestins and GRK in Dopaminergic Neurotransmission

    3 Arrestins in Serotonergic Neurotransmission

    4 Arrestins in Noradrenergic Neurotransmission

    5 Arrestins in Opioid Receptor Signaling

    6 Arrestins and Corticotropin Receptors

    7 Other β-arrestin-Dependent Behavior

    8 Conclusions

    Acknowledgment

    References

    Chapter Twelve. Arrestins in the Cardiovascular System

    1 Introduction

    2 Cardiovascular Adrenergic Receptors and βarrs

    3 Cardiovascular Angiotensin II Receptors and βarrs

    4 Other Cardiovascular GPCRs and βarrs

    5 Cardiovascular Non-GPCRs and βarrs

    6 Biased Agonism/Antagonism of Cardiovascular GPCR Ligands

    7 Perspectives and Future Directions

    8 Conclusions

    References

    Chapter Thirteen. Arrestins in Bone

    Abbreviations

    1 Introduction

    2 Arrestin Signaling: A New Dimension to GCPR Signaling in Bone

    3 Functional Selectivity in Bone

    4 Arrestin Signaling Effects in Bone

    5 Perspectives and Future Directions

    6 Conclusions

    Acknowledgments

    References

    Chapter Fourteen. β-Arrestins in the Immune System

    1 Introduction

    2 β-Arrestins in Innate Immunity

    3 β-Arrestins in Adaptive Immunity

    4 β-Arrestins and Structural Cells

    5 β-Arrestins Regulate Immune Signaling Pathways

    6 Role of β-Arrestins in Human Diseases

    7 β-Arrestins in Therapeutic Development for Inflammatory Diseases

    References

    Chapter Fifteen. The Role of β-Arrestins in Cancer

    1 Introduction

    2 ARRBs and Cancer-Associated Cell Phenotypes

    3 The Role of ARRBs in Cancer

    4 Conclusions

    Acknowledgments

    References

    Chapter Sixteen. Arrestins in Metabolic Regulation

    1 A Short Introduction to Metabolic Regulation

    2 Functional Roles of β-Arrestins in Regulation of Whole-Body Energy Balance and Body Weight Control

    3 Functional Role of β-Arrestins in Regulation of Carbohydrate and Lipid Homeostasis

    4 Conclusions

    References

    Part IV: The Future - The Potential for Arrestin-based Therapeutics

    Chapter Seventeen. Systems Analysis of Arrestin Pathway Functions

    1 G Protein-Coupled Receptor Signaling Activity

    2 Signaling Diversity Among GPCRs

    3 Systems Analysis of Receptor Signaling Systems

    4 Functional Analyses of Arrestin Signaling Paradigms

    5 Conclusions

    Acknowledgments

    References

    Chapter Eighteen. Arrestin Pathways as Drug Targets

    1 Introduction

    2 Biased GPCR Agonism

    3 The Many Faces of Arrestin-Dependent Biased Agonism

    4 The Conserved Arrestin-Dependent Signaling Repertoire

    5 Conclusions

    Acknowledgments

    References

    Index

Product details

  • No. of pages: 536
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: June 10, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123944405
  • eBook ISBN: 9780123947895

About the Serial Volume Editor

Louis M. Luttrell

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