The Molecular Basis of Cancer

4th Edition

Authors: John Mendelsohn Peter Howley Mark Israel Joe Gray Craig Thompson
Hardcover ISBN: 9781455740666
eBook ISBN: 9780323314732
Imprint: Saunders
Published Date: 19th February 2014
Page Count: 888

Description

2015 BMA Medical Book Awards Highly Commended in Oncology Category!

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application.

Key Features

  • Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer.
  • Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures.
  • Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy.

Table of Contents

The Molecular Basis of Cancer, 4e

Mendelsohn, Howley, Israel, Gray, Thompson

 

Part I: Carcinogenesis and Cancer Genetics

1. Cancer, A Genetic Disorder

2. Oncogenes and Signal Transduction

3. Tumor Suppressor Genes

4. Genomic Instability and DNA Repair

5. Epigenetics and Cancer

6. Infectious Agents and Cancer

7. Environmental Carcinogenesis

8. Animal Models: Flies, Fish and Yeast

9. Genetic Mouse Models of Cancer

Part II: Cancer Biology

10. Cancer Stem Cells

11. Regulation of the Cell Cycle

12. Cell Growth

13. Cancer Cell Metabolism

14. Apoptosis, Autophagy and Necrosis

15. Cell Growth Arrest and Senescence

  16. Stromal-Cancer Interactions in the Microenvironment

  17. Hypoxia and Angiogenesis

18. Invasion and Metastasis

19. Inflammation and Cancer

  20. Molecular Pathways and Systems Biology

Part III: Molecular Pathology and Diagnostics

21. Biomarkers Assessing Risk of Cancer

22. Biomarkers for Detecting Cancer: Molecular Screening

  23. Biomarkers for Predicting Response to Specific Therapy

24. The Technology of Analyzing Nucleic Acids

25. Imaging Cancer

  

Details

No. of pages:
888
Language:
English
Copyright:
© Saunders 2015
Published:
Imprint:
Saunders
eBook ISBN:
9780323314732
eBook ISBN:
9780323261968
Hardcover ISBN:
9781455740666

About the Author

John Mendelsohn

Affiliations and Expertise

Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas

Peter Howley

Affiliations and Expertise

Shattuck Professor of Pathological Anatomy, Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachusetts

Mark Israel

Affiliations and Expertise

Director, Norris Cotton Cancer Center, Professor of Pediatrics and Genetics, Dartmouth Medical School, Hanover, New Hampshire

Joe Gray

Affiliations and Expertise

Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University (OHSU) Director, OHSU Center for Spatial Systems Biomedicine, Portland, Oregon; Emeritus Professor, UCSF, and Visiting Faculty, Lawrence Berkeley National Laboratory, Berkeley, California

Craig Thompson

Affiliations and Expertise

President and CEO, Memorial Sloan-Kettering Cancer Center, New York, New York