The Molecular Basis of Cancer

The Molecular Basis of Cancer

4th Edition - February 19, 2014

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  • Authors: John Mendelsohn, Peter Howley, Mark Israel, Joe Gray, Craig Thompson
  • eBook ISBN: 9780323261968
  • Hardcover ISBN: 9781455740666

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2015 BMA Medical Book Awards Highly Commended in Oncology Category!The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application.

Key Features

  • Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer.
  • Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures.
  • Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy.

Table of Contents

  • The Molecular Basis of Cancer, 4e

    Mendelsohn, Howley, Israel, Gray, Thompson


    Part I: Carcinogenesis and Cancer Genetics

    1. Cancer, A Genetic Disorder

    2. Oncogenes and Signal Transduction

    3. Tumor Suppressor Genes

    4. Genomic Instability and DNA Repair

    5. Epigenetics and Cancer

    6. Infectious Agents and Cancer

    7. Environmental Carcinogenesis

    8. Animal Models: Flies, Fish and Yeast

    9. Genetic Mouse Models of Cancer

    Part II: Cancer Biology

    10. Cancer Stem Cells

    11. Regulation of the Cell Cycle

    12. Cell Growth

    13. Cancer Cell Metabolism

    14. Apoptosis, Autophagy and Necrosis

    15. Cell Growth Arrest and Senescence

      16. Stromal-Cancer Interactions in the Microenvironment

      17. Hypoxia and Angiogenesis

    18. Invasion and Metastasis

    19. Inflammation and Cancer

      20. Molecular Pathways and Systems Biology

    Part III: Molecular Pathology and Diagnostics

    21. Biomarkers Assessing Risk of Cancer

    22. Biomarkers for Detecting Cancer: Molecular Screening

      23. Biomarkers for Predicting Response to Specific Therapy

    24. The Technology of Analyzing Nucleic Acids

    25. Imaging Cancer


Product details

  • No. of pages: 888
  • Language: English
  • Copyright: © Saunders 2014
  • Published: February 19, 2014
  • Imprint: Saunders
  • eBook ISBN: 9780323261968
  • Hardcover ISBN: 9781455740666

About the Authors

John Mendelsohn

Affiliations and Expertise

Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas

Peter Howley

Affiliations and Expertise

Shattuck Professor of Pathological Anatomy, Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachusetts

Mark Israel

Affiliations and Expertise

Director, Norris Cotton Cancer Center, Professor of Pediatrics and Genetics, Dartmouth Medical School, Hanover, New Hampshire

Joe Gray

Affiliations and Expertise

Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University (OHSU) Director, OHSU Center for Spatial Systems Biomedicine, Portland, Oregon; Emeritus Professor, UCSF, and Visiting Faculty, Lawrence Berkeley National Laboratory, Berkeley, California

Craig Thompson

Affiliations and Expertise

President and CEO, Memorial Sloan-Kettering Cancer Center, New York, New York

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