The Molecular Basis of Cancer
4th Edition
Description
2015 BMA Medical Book Awards Highly Commended in Oncology Category!
The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application.
Key Features
- Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer.
- Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures.
- Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy.
Table of Contents
The Molecular Basis of Cancer, 4e
Mendelsohn, Howley, Israel, Gray, Thompson
Part I: Carcinogenesis and Cancer Genetics
1. Cancer, A Genetic Disorder
2. Oncogenes and Signal Transduction
3. Tumor Suppressor Genes
4. Genomic Instability and DNA Repair
5. Epigenetics and Cancer
6. Infectious Agents and Cancer
7. Environmental Carcinogenesis
8. Animal Models: Flies, Fish and Yeast
9. Genetic Mouse Models of Cancer
Part II: Cancer Biology
10. Cancer Stem Cells
11. Regulation of the Cell Cycle
12. Cell Growth
13. Cancer Cell Metabolism
14. Apoptosis, Autophagy and Necrosis
15. Cell Growth Arrest and Senescence
16. Stromal-Cancer Interactions in the Microenvironment
17. Hypoxia and Angiogenesis
18. Invasion and Metastasis
19. Inflammation and Cancer
20. Molecular Pathways and Systems Biology
Part III: Molecular Pathology and Diagnostics
21. Biomarkers Assessing Risk of Cancer
22. Biomarkers for Detecting Cancer: Molecular Screening
23. Biomarkers for Predicting Response to Specific Therapy
24. The Technology of Analyzing Nucleic Acids
25. Imaging Cancer
Details
- No. of pages:
- 888
- Language:
- English
- Copyright:
- © Saunders 2014
- Published:
- 4th January 2014
- Imprint:
- Saunders
- eBook ISBN:
- 9780323261968
- Hardcover ISBN:
- 9781455740666
About the Authors
John Mendelsohn
Affiliations and Expertise
Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Peter Howley
Affiliations and Expertise
Shattuck Professor of Pathological Anatomy, Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, Massachusetts
Mark Israel
Affiliations and Expertise
Director, Norris Cotton Cancer Center, Professor of Pediatrics and Genetics, Dartmouth Medical School, Hanover, New Hampshire
Joe Gray
Affiliations and Expertise
Gordon Moore Professor and Chair, Biomedical Engineering, Oregon Health and Science University (OHSU) Director, OHSU Center for Spatial Systems Biomedicine, Portland, Oregon; Emeritus Professor, UCSF, and Visiting Faculty, Lawrence Berkeley National Laboratory, Berkeley, California
Craig Thompson
Affiliations and Expertise
President and CEO, Memorial Sloan-Kettering Cancer Center, New York, New York
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