The molecular aspects of autoimmunity - 1st Edition - ISBN: 9780122490408, 9780323156233

The molecular aspects of autoimmunity

1st Edition

Editors: Nadir Farid
eBook ISBN: 9780323156233
Imprint: Academic Press
Published Date: 28th February 1990
Page Count: 318
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Description

The Molecular Aspects of Autoimmunity contains a selection of the papers presented at the first of a series of biannual meetings on molecular aspects of autoimmunity held in L'Esterel, Quebec, Canada, October 30-November 2, 1988. The book contains 20 chapters and begins with a study of the expression of the Ly-1 gene and V gene families in autoantibodies. This is followed by separate chapters on the structural characteristics of human IgM autoantibodies; human IgV gene segments for autoantibodies; and the genetic basis of anti-DNA immune responses. Subsequent chapters cover topics such as the epibodies from the immune response to the acetylcholine receptor (AChR); the specificities and idiotypes of anti-histone H1 autoantibodies; T cell tolerance; and T cell antigen receptor (TCR) gene biology and the genomic composition and expressed repertoire of these genes in several autoimmune and normal mouse strains. Also discussed are MHC Class II associations with autoimmune disorders such as type 1 diabetes, rheumatoid arthritis, and thyroid disease.

Table of Contents


Contributors

Preface

The Expression of LY-1 and Immunoglobulin Variable Gene Families in Hybridomas Producing Autoantibodies of Various Specificities

Structural Characteristics of Human IgM Autoantibodies

Molecular Genetics of Human Autoantibodies

Molecular Characterization of Human Anti-DNA Antibodies

From Idiotypic Expression of Lupus Anti-DNA Antibodies to Diversification of Ig Variable Region Genes

Murine Autoantibodies Specific for Bromelinized Red Blood Cells Use Restricted Set of Genetic Elements and Their Heavy Chains Define a Novel VH Family

Molecular Analysis of Murine Lupus-Associated Humoral Anti-Self Response

Establishment of V-Gene Repertoires in Normal Mice

Characterization of a Regulatory Idiotope by Antibody Engineering

Epibodies in the Immune Response to the Acetylcholine Receptor

Interspecies Idiotypes on Anti-Sm Antibodies

Specificities and Idiotypy of Anti-Histone HI Autoantibodies

Experimental Models of T Cell Tolerance

Genomic and Expressed T Cell Antigen Receptor Repertoire in Autoimmune Murine Models

Structure of the Human Interleukin 2 Receptor and the Biochemical Basis for Its Regulation

Viruses as a Triggering Factor of Autoimmune Type I Diabetes

Mapping Susceptibility to Rheumatoid Arthritis into a Conformationally Equivalent Region of MHC Class II Molecules Encoded by Different Alleles

In Vitro Model Systems for the Study of Thyroid Autoimmunity: Regulation of Rat MHC Class II Antigens

The Molecular Basis of MHC Association with Disease

Basic Role for Anti-Idiotype Autoantibodies in the Prevention of Experimental Autoimmune Thyroiditis

Index


Details

No. of pages:
318
Language:
English
Copyright:
© Academic Press 1990
Published:
Imprint:
Academic Press
eBook ISBN:
9780323156233

About the Editor

Nadir Farid